Results 161 to 170 of about 11,902 (192)

Tertiary lymphoid structures in cancer

Science, 2022
Tertiary lymphoid structures in cancer Tertiary lymphoid structures (TLSs) are lymphoid formations that are found in nonlymphoid tissues. TLS can develop in inflamed tissues and are associated with chronic inflammatory disorders, autoimmunity, and cancer. In the setting of tumors, TLSs facilitate the influx of immune cells into the tumor site
Ton N. Schumacher, Daniela S. Thommen
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Tertiary lymphoid structures in cancer and beyond

Trends in Immunology, 2014
Tertiary lymphoid structures (TLS) are ectopic lymphoid formations found in inflamed, infected, or tumoral tissues. They exhibit all the characteristics of structures in the lymph nodes (LN) associated with the generation of an adaptive immune response, including a T cell zone with mature dendritic cells (DC), a germinal center with follicular ...
Marie-Caroline Dieu-Nosjean, Jeremy Goc, Nicolas A Giraldo   +2 more
exaly   +3 more sources

Tertiary Lymphoid Structures Validated as Biomarker

Cancer Discovery, 2023
Abstract New trial data confirm the potential of tertiary lymphoid structures to serve as a predictive biomarker of responsiveness to an immune checkpoint inhibitor–based drug regimen. According to study results presented at the Society for Immunotherapy of Cancer Annual Meeting, treatment with a PD-L1–targeted agent plus a multikinase ...
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Maturation of Tertiary Lymphoid Structures

Tertiary lymphoid structures (TLS) are organized collections of B and T lymphocytes that arise in nonlymphoid tissue in response to chronic, unresolved inflammation. TLS have structural and functional similarities to germinal centers found in lymph nodes and are believed to support the establishment of lymph node-like adaptive immune responses at local
Daniel H, Shu, Dimitrios N, Sidiropoulos
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Innate Immunity and Tertiary Lymphoid Structures

Immunological Reviews
ABSTRACTTertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that form in response to chronic inflammation, such as in autoimmune diseases or cancer. Their presence has been increasingly recognized as a significant factor in determining patient prognosis and response to cancer treatments.
Ruibo Zhao, Daxing Gao
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Tertiary lymphoid structures in anticancer immunity

Nature Reviews Cancer
Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates where adaptive antitumour cellular and humoral responses can be elaborated. Initially described in non-small cell lung cancer as functional immune lymphoid structures associated with better clinical outcome, TLS have also been found in many other carcinomas, as well as ...
Jean-Luc Teillaud, Ana Houel, Marylou Panouillot, Clémence Riffard, Marie-Caroline Dieu-Nosjean   +4 more
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An Introduction to Tertiary Lymphoid Structures in Cancer

Immunotherapy has revolutionized therapeutics for cancer patients, which signifies the importance of effective antitumor immunity in combatting cancer. However, the benefit of immunotherapies is limited to specific patient populations and tumor types, suggesting the overt need for new immunotherapeutic targets.
Hye Mi, Kim, Tullia C, Bruno
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Injectable hydrogel-based drug formulation for enhancing tertiary lymphoid structure formation and cancer immunotherapy efficacy

Journal of Controlled Release
Tertiary lymphoid structures (TLSs) in the tumor microenvironment are associated with improved cancer prognosis and enhanced immune checkpoint blockade (ICB) responses.
Chaiyaporn Kuwentrai, Xuansheng Lin, Matthew J Webber   +2 more
exaly   +2 more sources

Targeting Tertiary Lymphoid Structures for Tumor Immunotherapy

2018
Tumor microenvironments (TME) are usually immunosuppressive and prevent lymphocyte priming. Recent clinical trials have shown that cancer immunotherapy such as immune checkpoint inhibitors can induce unprecedented durable responses in patients with a variety of cancers. Tertiary lymphoid structures (TLS) can form inside or adjacent to tumor tissues due
Haidong, Tang, Xiangyan, Qiu, Casey, Timmerman, Yang-Xin, Fu   +3 more
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Microorganisms in cancer tertiary lymphoid structure formation

Seminars in Cancer Biology
Tertiary lymphoid structures (TLSs) are essential in cancer immunotherapy, markedly improving the efficacy of immune checkpoint blockade (ICB) therapy. The presence of TLSs within the tumor microenvironment (TME) is associated with improved responses to ICB therapy, making them valuable biomarkers for predicting the efficacy of ICB therapy.
Hao, Li, Fei-Yang, Chen, Qing, Wang, Tian-Fu, Wu, Zhi-Jun, Sun   +4 more
openaire   +2 more sources