Results 221 to 230 of about 11,725 (256)

The formation and function of tertiary lymphoid structures

Biomarker Research
Chengzhang Zhang, Peng Lv, Yaxin Hou, Zhipeng Yao, Shuping Jiang, Ke Chen, Zheng Liu, Lilong Liu   +7 more
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Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell Carcinoma. [PDF]

Int J Biol Sci
Zhou S, Ye S, Chen L, Ge Q, Lu J, Anwaier A, Tian X, Wang Z, Zhu S, Chang K, Yang J, Li T, Zhang H, Ye D, Xiang J, Xu W.   +15 more
europepmc   +1 more source

Identification of a tertiary lymphoid structure (TLS)-related signature for ovarian cancer prognosis suggests a potential role of STAT5A in TLS maturation. [PDF]

Genes Dis
Yang J, Zhang Y, Cheng S, Xu Y, Wu M, Gu S, Ma M, Zhao Y, Wang C, Wang Y.   +9 more
europepmc   +1 more source

FLT3 is associated with dendritic cell infiltration, tertiary lymphoid structure construction, and predict response to checkpoint inhibitors immunotherapy in solid cancers. [PDF]

Sci Rep
Tang Y, Wang H, Zhang J, Yang C, Xu F, Song Y, Li T, Zhang Q.   +7 more
europepmc   +1 more source

Multi-Algorithm-Integrated Tertiary Lymphoid Structure Gene Signature for Immune Landscape Characterization and Prognosis in Colorectal Cancer Patients. [PDF]

Biomedicines
Liu X, Li D, Zhang Y, Liu H, Chen P, Zhao Y, Sun G, Zhao W, Dong G.   +8 more
europepmc   +1 more source

Spatial patterns and MRI-based radiomic prediction of high peritumoral tertiary lymphoid structure density in hepatocellular carcinoma: a multicenter study. [PDF]

J Immunother Cancer
Long S, Li M, Chen J, Zhong L, Abudulimu A, Zhou L, Liu W, Pan D, Dai G, Fu K, Chen X, Pei Y, Li W.   +12 more
europepmc   +1 more source

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Tertiary lymphoid structures in cancer

Science, 2022
Tertiary lymphoid structures in cancer Tertiary lymphoid structures (TLSs) are lymphoid formations that are found in nonlymphoid tissues. TLS can develop in inflamed tissues and are associated with chronic inflammatory disorders, autoimmunity, and cancer. In the setting of tumors, TLSs facilitate the influx of immune cells into the tumor site
Ton N. Schumacher, Daniela S. Thommen
openaire   +2 more sources

Tertiary lymphoid structures in cancer and beyond

Trends in Immunology, 2014
Tertiary lymphoid structures (TLS) are ectopic lymphoid formations found in inflamed, infected, or tumoral tissues. They exhibit all the characteristics of structures in the lymph nodes (LN) associated with the generation of an adaptive immune response, including a T cell zone with mature dendritic cells (DC), a germinal center with follicular ...
Wolf Herman Fridman, Marie-Caroline Dieu-Nosjean, Jeremy Goc   +2 more
exaly   +3 more sources

Tertiary Lymphoid Structures Validated as Biomarker

Cancer Discovery, 2023
Abstract New trial data confirm the potential of tertiary lymphoid structures to serve as a predictive biomarker of responsiveness to an immune checkpoint inhibitor–based drug regimen. According to study results presented at the Society for Immunotherapy of Cancer Annual Meeting, treatment with a PD-L1–targeted agent plus a multikinase ...
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Maturation of Tertiary Lymphoid Structures

Tertiary lymphoid structures (TLS) are organized collections of B and T lymphocytes that arise in nonlymphoid tissue in response to chronic, unresolved inflammation. TLS have structural and functional similarities to germinal centers found in lymph nodes and are believed to support the establishment of lymph node-like adaptive immune responses at local
Daniel H, Shu, Dimitrios N, Sidiropoulos
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