Results 231 to 240 of about 11,725 (256)

Innate Immunity and Tertiary Lymphoid Structures

Immunological Reviews
ABSTRACTTertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that form in response to chronic inflammation, such as in autoimmune diseases or cancer. Their presence has been increasingly recognized as a significant factor in determining patient prognosis and response to cancer treatments.
Ruibo Zhao, Daxing Gao
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Tertiary lymphoid structures in anticancer immunity

Nature Reviews Cancer
Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates where adaptive antitumour cellular and humoral responses can be elaborated. Initially described in non-small cell lung cancer as functional immune lymphoid structures associated with better clinical outcome, TLS have also been found in many other carcinomas, as well as ...
Jean-Luc Teillaud, Ana Houel, Marylou Panouillot, Clémence Riffard, Marie-Caroline Dieu-Nosjean   +4 more
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An Introduction to Tertiary Lymphoid Structures in Cancer

Immunotherapy has revolutionized therapeutics for cancer patients, which signifies the importance of effective antitumor immunity in combatting cancer. However, the benefit of immunotherapies is limited to specific patient populations and tumor types, suggesting the overt need for new immunotherapeutic targets.
Hye Mi, Kim, Tullia C, Bruno
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Involvement of lymphoid inducer cells in the development of secondary and tertiary lymphoid structure

BMB Reports, 2009
During development lymphoid tissue inducer (LTi) cells are the first hematopoietic cells to enter the secondary lymphoid anlagen and induce lymphoid tissue neogenesis. LTi cells induce lymphoid tissue neogensis by expressing a wide range of proteins that are associated with lymphoid organogenesis.
Isabel, Evans, Mi-Yeon, Kim
exaly   +4 more sources

Targeting Tertiary Lymphoid Structures for Tumor Immunotherapy

2018
Tumor microenvironments (TME) are usually immunosuppressive and prevent lymphocyte priming. Recent clinical trials have shown that cancer immunotherapy such as immune checkpoint inhibitors can induce unprecedented durable responses in patients with a variety of cancers. Tertiary lymphoid structures (TLS) can form inside or adjacent to tumor tissues due
Haidong, Tang, Xiangyan, Qiu, Casey, Timmerman, Yang-Xin, Fu   +3 more
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Microorganisms in cancer tertiary lymphoid structure formation

Seminars in Cancer Biology
Tertiary lymphoid structures (TLSs) are essential in cancer immunotherapy, markedly improving the efficacy of immune checkpoint blockade (ICB) therapy. The presence of TLSs within the tumor microenvironment (TME) is associated with improved responses to ICB therapy, making them valuable biomarkers for predicting the efficacy of ICB therapy.
Hao, Li, Fei-Yang, Chen, Qing, Wang, Tian-Fu, Wu, Zhi-Jun, Sun   +4 more
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Tertiary Lymphoid Structures: Allies of Cancer Immunotherapy

Immunology
ABSTRACTImmunotherapy has demonstrated groundbreaking clinical efficacy across diverse cancer types. Nevertheless, its therapeutic potential remains constrained, with only a small subset of patients achieving durable clinical responses. Emerging evidence highlights tertiary lymphoid structures (TLSs), ectopic lymphoid aggregates induced by chronic ...
Xinze Li, Xinnan Zhang, Zhiyong Cao, Jianhua Guan, Feng Qiu, Qiang Zhang, Ning Kang   +6 more
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Cellular and Vascular Components of Tertiary Lymphoid Structures

2018
Inflammatory immune cells recruited at the site of chronic inflammation form structures that resemble secondary lymphoid organs (SLO). These are characterized by segregated areas of prevalent T- or B-cell aggregation, differentiation of high endothelial venules, and local activation of resident stromal cells, including lymphatic endothelial cells.
Christopher George, Mueller, Saba, Nayar, David, Gardner, Francesca, Barone   +3 more
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Tertiary Lymphoid Structures Among the World of Noncanonical Ectopic Lymphoid Organizations

2018
Tertiary lymphoid structures (TLOs), also known as ectopic lymphoid structures, are associated with chronic infections and inflammatory diseases. Despite their association with pathology, these structures are actually a normal, albeit transient, component of the immune system and facilitate local immune responses that are meant to mitigate inflammation
Aaron, Silva-Sanchez, Troy D, Randall, Selene, Meza-Perez   +2 more
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The Evolving Landscape of Bladder Tertiary Lymphoid Structures

Journal of Urology, 2023
Madhuri, Koti, D Robert, Siemens
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