Results 121 to 130 of about 6,088 (246)

Tertiary lymphoid structures in the microenvironment of colorectal cancer: exploring new therapeutic targets

Cancer Immunology, Immunotherapy
Immunotherapy has shown limited efficacy in colorectal cancer (CRC), necessitating the urgent identification of novel immunotherapeutic targets to address this challenge.
Nan-Nan Dai, Man-Yi Hu, Jian-Ping Wang, Zhi-Hui Dai, Li Xu, Tai-Wei Ye   +5 more
doaj   +1 more source

Prognostic Value of N1/N2 Neutrophils Heterogeneity and Tertiary Lymphoid Structure in Hepatocellular Carcinoma Patients

Cancer Medicine
Background The tumor immune microenvironment, including neutrophils and tertiary lymphoid structures (TLSs), is pivotal for HCC prognosis assessment. Tumor‐associated neutrophils exhibit plasticity, adopting either an antitumorigenic N1 (MPO+ CD206−) or ...
Yanfei Lang, Weiwei Fu, Wei Xu, Chao Ma, Xiuyun Tian, Chunyi Hao, Shigang Ding   +6 more
doaj   +1 more source

Sustained innate interferon is an essential inducer of tertiary lymphoid structures [PDF]

Tertiary lymphoid structures (TLS) resemble follicles of secondary lymphoid organs and develop in nonlymphoid tissues during inflammation and cancer. Which cell types and signals drive the development of TLS is largely unknown.
Calvanese, Anna Laura, Cecconi, Virginia, Gschwend, Julia, Heikenwälder, Mathias, Ludewig, Burkhard, Nater, Marc, Pereira, Paulo, Schneider, Christoph, Schnepf, Daniel, Silina, Karina, Stäheli, Severin, van den Broek, Maries   +11 more
core   +1 more source

Assessment of tertiary lymphoid structures in salivary glands, pancreas, and lungs of NZB/W lupus prone mice. [PDF]

, 2020
Autoimmune diseases are complex genetic traits. Factors that trigger autoimmune diseases have yet to be deciphered. It is however suspected that a combination of copious risk factors is implicated in the development of autoimmunity.
Miancho, Diana Roza Kibancha
core  

The impact of tertiary lymphoid structure on the efficacy of postoperative adjuvant transcatheter arterial chemoembolization in patients with hepatocellular carcinoma

Zhongguo Linchuang Yixue
ObjectiveTo explore the impact of tertiary lymphoid structure (TLS) on the efficacy of adjuvant transcatheter arterial chemoembolization (TACE) following curative resection in patients with hepatocellular carcinoma (HCC).
Fansheng MENG, Haokang YANG, Biwei YANG
doaj   +1 more source

A distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy sensitive than papillary thyroid cancer

JCI Insight
Both anaplastic thyroid cancer (ATC) and papillary thyroid cancer (PTC) originate from thyroid follicular epithelial cells, but ATC has a significantly worse prognosis and shows resistance to conventional therapies.
Pei-Zhen Han, Wei-Dong Ye, Peng-Cheng Yu, Li-Cheng Tan, Xiao Shi, Xu-Feng Chen, Cong He, Jia-Qian Hu, Wen-Jun Wei, Zhong-Wu Lu, Ning Qu, Yu Wang, Qing-Hai Ji, Dong-Mei Ji, Yu-Long Wang   +14 more
doaj   +1 more source

Tertiary lymphoid structure-related score as a predictor for survival prognosis and immunotherapy response in head and neck squamous cell carcinoma

Frontiers in Immunology
BackgroundSubstantial studies reveal that tertiary lymphoid structure (TLS) correlate with prognosis and immunotherapy response in various types of cancers.
Fan Wu, Fan Wu, Haotian Cao, Haotian Cao, Siqi Ren, Siqi Ren, Jiaying Wu, Jiaying Wu, Xin Liu, Xin Liu, Qunxing Li, Qiuping Xu, Qiuping Xu, Jiali Chen, Jiali Chen, Ruixin Wang, Ruixin Wang, Suling Chen, Suling Chen, Shijia Kuang, Shijia Kuang, Binbin Xia, Yanyan Li, Yanyan Li, Liansheng Wang, Jintao Li, Bowen Li, Bowen Li, Jinsong Li, Jinsong Li, Tianjun Lan, Tianjun Lan   +31 more
doaj   +1 more source

Tertiary Lymphoid Structures Are Associated with Favorable Clinical Outcomes and Negatively Correlated with Cancer-Associated Fibroblasts in Esophageal Cancer [PDF]

Background: Esophageal cancer remains a highly aggressive malignant tumor with poor prognosis, despite advances in combination therapies and novel immunotherapies.
Akai, Masaaki, Fujiwara, Toshiyoshi, Kawasaki, Kento, Kikuchi, Satoru, Kunitomo, Tomoyoshi, Maeda, Naoaki, Matsumoto, Hijiri, Nishimura, Seitaro, Nishiwaki, Noriyuki, Noma, Kazuhiro, Ohara, Toshiaki, Shirakawa, Yasuhiro, Takahashi, Tatsuya, Takeda, Yasushige, Tanabe, Shunsuke, Tazawa, Hiroshi   +15 more
core   +1 more source

IL-36 gamma promotes anti-tumor immunity through therapeutic induction of tumor-associated tertiary lymphoid structures [PDF]

, 2018
The last decade has advanced our understanding of the composition of the tumor-immune microenvironment and its role as a potential target for therapeutic intervention.
Weinstein, Aliyah M
core  

HLA class II neoantigen presentation for CD4+ T cell surveillance in HLA class II-negative colorectal cancer [PDF]

札幌医科大学博士（医学）doctoral ...
松本, 哲
core   +2 more sources