Results 211 to 220 of about 6,745 (243)

Correlation analysis of tertiary lymphoid structure parameters with the prognosis of patients with locally advanced rectal cancer after neoadjuvant chemotherapy: a retrospective study

World Journal of Surgical Oncology
The tertiary lymphoid structures (TLSs) are positively correlated with the prognosis of many solid tumors, including colorectal cancer. However, their prognostic significance in patients with locally advanced rectal cancer (LARC) after neoadjuvant ...
Yingjian Jiang, Chuang Zhang, Yifei Hou, Bin Zhao, Binbin Cui   +4 more
semanticscholar   +1 more source

CCL20 secreted by KRT15high tumor Cells promotes tertiary lymphoid structure formation and enhances anti-PD-1 therapy response in HPV+HNSCC

Cell Death and Disease
Tertiary lymphoid structures (TLS) are associated with an improved response to Immune checkpoint therapy (ICT) in head and neck squamous cell carcinoma (HNSCC). Human papillomavirus (HPV) infection constitutes a high-risk factor for HNSCC carcinogenesis.
Siwei Zhang, Huan Liu, Xiaoxing Li, Yourong Jiang, Lu Tang, Tianyang Liu, Rui Li, Zengchen Liu, Minghui Wei, Jingchun Sun, Zhuledesi Hahan, Heng Ma, Lanlan Wei   +12 more
semanticscholar   +1 more source

A Tertiary Lymphoid Structure-Related Gene Signature Predicts Prognosis and Treatment Response in Hepatocellular Carcinoma

World Journal of Oncology
Background Hepatocellular carcinoma (HCC) carries a poor prognosis with limited treatment options. Tertiary lymphoid structures (TLS) impact tumor immunity, but their role in HCC requires clarification.
X. Kong, Xiao Li, X. Qiu, Ming Ma, Jin Liu, Zi Wang, Zihui Meng, Shangwei Ji   +7 more
semanticscholar   +1 more source

Abstract PO4-25-04: MHC Class I and II Expression, Functional Tertiary Lymphoid Structure (TLS), and Outcomes in Early-Stage HER2-Positive (HER2+) Breast Cancer in NCCTG N9831 (Alliance)

Cancer Research
Abstract Background: Tertiary lymphoid structure (TLS) is an organized form of ectopic lymphoid aggregates (LA) with secondary lymphoid organ structure. Several studies showed that the presence of TLS associates with improved outcomes in multiple cancers when treated with immune checkpoint inhibitors.
Saranya Chumsri, Tracy Shachner, Zhuo Li, Nadine Norton, Alvaro Moreno-Aspitia, Gerardo Colon-Otero, Edith Perez, Aziza Nassar, E. Thompson, Keith Knutson   +9 more
openaire   +1 more source

Artificial Intelligence and Multi-modality Data Integration Deciphers Tertiary Lymphoid Structure Maturity in Gastric Cancer.

Cancer Research
Tertiary lymphoid structures (TLSs) are critical components of the tumor microenvironment in gastric cancer (GC), but clinical assessment of TLS is challenging.
Wenxuan Wu, Zhenzhen Xun, Yaxuan Han, Qimiao Chen, Shaojun Yu, Yikai Luo, Zhixing Hao, Jing Chen, Yewei Xu, Xiaying Han, Jia Qi, Kai Song, Xiaojing Ma, Yongyuan Yhen, Guofeng Chen, Muxing Kang, Xiaoli Jin, Yuan Ding, Zhiqiang Zhu, Can Hu, Xiangdong Cheng, Lie Wang, Pin Wu, Han Liang, Jian Chen   +24 more
semanticscholar   +1 more source

Abstract PS2-09-08: Tertiary lymphoid structure (TLS)-related gene expression and outcomes in HER2-Positive (HER2+) breast cancer (BC) in the Real-World Database

Clinical Cancer Research
Abstract Background: Tertiary lymphoid structures (TLS), which are organized ectopic lymphoid aggregates resembling secondary lymphoid organs, have been associated with improved outcomes across various cancer types.
S. Chumsri, S. Deshmukh, Y. Liu, S. Wu, J. Xiu, N. Norton, S. Shipra Gandhi, E. Torres, M. Lustberg, E. Perez, A. Nassar, G. Sledge, E. Thompson, K. Knutson   +13 more
openaire   +1 more source

SO016/#846  Deep learning for spatial distribution of tertiary lymphoid structures (TLS) and efficacy of immunotherapy for endometrial cancer

Closing Session: the Development of Prognosis and Predictive Markers, 2023
Junzo Hamanishi, Haruka Suzuki, Akihiko Ueda, Ken Yamaguchi, Masaki Mandai   +4 more
openaire   +1 more source

Identifying the antigenic drivers of tertiary lymphoid structure formation in solid cancers 3205

Journal of Immunology
Tertiary Lymphoid Structures (TLSs) are ectopic lymphoid structures, formed in the presence of inflammation/tumors and are niches for antigen drainage. TLSs provide tumor-adjacent compartments to support cognate interactions of T follicular helper (
Mary Melissa Roland, Amy Zhou, Lyubov Kublo, Venkata Krishna Kanth Makani, Paul M. Zdinak, Alok V. Joglekar   +5 more
semanticscholar   +1 more source

Abstract 862: Dynamic hydrogel drug delivery systems for enhancing tertiary lymphoid structure formation and maturation

Cancer Research
Tertiary lymphoid structures (TLSs), also known as ectopic lymphoid structures, are organized lymphoid-like aggregates that can form within the tumor microenvironment.
Weilong Tang, Chaiyaporn Kuwentrai, Matthew J. Webber, Zhou Ye, Jiandong Huang   +4 more
semanticscholar   +1 more source

Abstract 3358: Tertiary lymphoid structures (TLS) estimated by AI tools from digital H&E slides significantly enhance survival prediction in high-risk AJCC stages III/IV melanoma

Cancer Research
Abstract Tertiary lymphoid structures (TLS) in tumors have emerged as novel disease prognostic and predictive biomarkers with immunotherapy. Recent advances in whole-slide image (WSI) digitization of pathology slides and AI tools are making in situ prediction of TLS more feasible. Methods:
Ahmad A. Tarhini, Tingyi Li, Ranran Tao, Sandra J. Lee, Islam Eljilany, F. Stephen Hodi, Howard Streicher, Arivarasan Karunamurthy, John M. Kirkwood, Xuefeng Wang   +9 more
openaire   +1 more source