Results 101 to 110 of about 29,370 (346)
Supplementary Figure 1 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8<sup>+</sup> T Cells [PDF]
, 2023 Jérémy Goc, Claire Germain, Thi Kim Duy Vo-Bourgais, Audrey Lupo, Christophe Klein, Samantha Knockaert, Luc de Chaisemartin, Hanane Ouakrim, Étienne Becht, Marco Alifano, Pierre Validire, Romain Remark, Scott A. Hammond, Isabelle Cremer, Diane Damotte, Wolf H. Fridman, Catherine Sautès‐Fridman, Marie‐Caroline Dieu‐Nosjean +17 moreopenalex +1 more sourceTargeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. [PDF]
, 2018 Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in cancer patients.Abnousian, Arbi, Bluestone, Jeffrey A, DuPage, Michel, Fong, Lawrence, Harwin, Tory, Mahuron, Kelly, Pagani, Massimiliano, Pai, Chien-Chun, Quiros, Jason, Ranzani, Valeria, Rosenblum, Michael D, Silveria, Stephanie, Van Gool, Frederic, Wang, David, Young, Arabella +14 morecore +2 more sourcesTertiary Lymphoid Structures in Microorganism-Related Cancer
CancersTertiary lymphoid structures (TLSs) are ectopic lymphoid tissues formed by the accumulation of lymphocytes and other components outside lymphoid organs. They have been shown to be widespread in cancers and have predictive effects on prognosis and immunotherapy efficacy; however, there is no standardized measurement guide.Shuzhe Deng, Xinxin Yang, Lin He, Yunjing Hou, Hongxue Meng +4 moreopenaire +2 more sourcesWDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis
Advanced Science, EarlyView.Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li +12 morewiley +1 more sourceInteractions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases [PDF]
, 2017 textabstractThe classical paradigm of tuberculosis (TB) immunity, with a central protective role for Th1 responses and IFN-γ-stimulated cellular responses, has been challenged by unsatisfactory results of vaccine strategies aimed at enhancing Th1 ...Abhimanyu, Achkar, Afshar, Amarilyo, Ambrosi, Andersson, Antonelli, Arnason, Asano, Ashenafi, Askenase, Avci, Axtell, Axtell, Babudieri, Baccala, Bach, Baechler, Bafica, Bandaru, Barber, Barnes, Basile, Basile, Behar, Belkahla, Bennett, Benson, Berclaz, Berry, Bjornsdottir, Blanco, Blanco, Blomgran, Boer, Boniface, Boum, Braian, Brkic, Brkic, Brkic, Bulat-Kardum, Caccamo, Campbell, Canavan, Carmona-Rivera, Chen, Chen, Choi, Cliff, Cohen, Colditz, Collins, Conrady, Cooper, Coquery, Correa, Coscolla, Cowan, Craft, Crouse, Crow, Crow, Croxford, Cruz, Cunningham, Dalod, de Bruin, de Jong, de Paus, Decker, Demers, Deng, Desvignes, Dey, Di Paolo, Divangahi, Dolff, Dorhoi, Doz, Dragon, Du, Edwards, El-Behi, Elkayam, Elkington, Eruslanov, Eshleman, Eum, Fairweather, Farah, Farkas, Fejer, Feng, Fischer, Fleetwood, Francis, Francois, Freches, Fremond, Gagliani, Ganguly, Garcia-Romo, Gautier, Giosue, Giosue, Godfrey, Gonzalez-Juarrero, Gopal, Gopal, Gopal, Goriely, Goriely, Grainger, Griffin, Grogan, Grosset, Guarda, Guardigni, Guenova, Hedlund, Heidarnezhad, Higgins, Higgs, Hochrein, Hoeksema, Hoeve, Houben, Huebener, Hwang, Ifergan, Ireland, Ivashkiv, Jacob, Jayaraman, Jiao, Jin, Jones, Jones, Joosten, Joosten, Jurado, Kalinski, Kaminskaia, Kara, Kearney, Keller, Khader, Khader, Kim, Kim, Kirou, Kisich, Klose, Knaul, Kolb-Maurer, Korn, Kumar, Lande, Langrish, Langrish, Lazar-Molnar, Lazarus, Li, Liang, Lichtner, Lienard, Lindau, Linterman, Litinskiy, Liu, Lockhart, Longhi, Lood, Lopez, Lozza, Lu, Luan, Lubberts, Lyadova, Lyadova, Lyakh, MacKenzie, Maertzdorf, Maione, Manca, Manca, Manni, Manry, Mansoori, Manzanillo, Mao, Marin, Marin, Mariotti, Martin, Matsuoka, Mayer-Barber, Mayer-Barber, McNab, McNab, McNab, Merrill, Metcalfe, Midgley, Milano, Mishra, Mobley, Moguche, Monin, Mourik, Mueller, Munari, Mvubu, Nakayamada, Nandi, Napolitani, Navarra, Ndiaye, Ng, Niewold, Noster, Novikov, Nunnari, Okada, Okamoto Yoshida, Olobo, Ordway, Ottenhoff, O’Garra, Pai, Palmero, Pandey, Parkes, Parsa, Paulson, Peng, Perreau, Pers, Persson, Puthia, Rahman, Ramos-Kichik, Rangel Moreno, Rangel-Moreno, Raphael, Rasouli, Reboldi, Redford, Remoli, Repasy, Roberts, Ronnblom, Ronnblom, Roses, Rothchild, Rottenberg, Rovin, Russell, Sabbatani, Sage, Saiga, Sakai, Saraav, Sargentini, Scaffidi, Scapini, Schett, Schiffer, Schlitzer, Schreiber, Schreiber, Scordo, Scriba, Serezani, Shah, Shaler, Shapira, Shen, Shi, Shiomi, Shishikura, Shu, Sierra-Filardi, Silverpil, Simpson, Singh, Sjostrand, Slight, Sorgi, Spits, Stanley, Stephen-Victor, Stifter, Stohl, Strachan, Sutton, Swiecki, Szczucinski, Szeliga, Tada, Tall, Tameris, Teles, Telesca, Terawaki, Thien, Tian, Tian, Toossi, Torrado, Toubi, Trentini, Trinchieri, Tsai, Tsiganov, Tully, Ueno, Ulrichs, Umemura, Une, van Meijgaarden, van Nieuwenhuijze, Verreck, Verreck, Vincent, Vogt, von Scheidt, Wahren-Herlenius, Wang, Wassermann, Watson, Wilson, Wolf, Wong, Xu, Yamazaki, Yeremeev, Yoshimura, Zak, Zarogoulidis, Zhang, Zhang, Zhou, Zhou, Zitvogel, Zizzo, Zollars +347 morecore +4 more sourcesThe Tumor Immune Landscape and Architecture of Tertiary Lymphoid Structures in Urothelial Cancer [PDF]
, 2021 Nick van Dijk, Alberto Gil-Jimenez, Karīna Siliņa, Maurits L. van Montfoort, Sarah Einerhand, Lars Jonkman, Charlotte S. Voskuilen, Dennis Peters, Joyce Sanders, Yoni Lubeck, Annegien Broeks, Erik Hooijberg, Daniël J. Vis, Maries van den Broek, Lodewyk F.A. Wessels, Bas W.G. van Rhijn, Michiel S. van der Heijden +16 moreopenalex +1 more sourceIL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma
Advanced Science, EarlyView.Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu +16 morewiley +1 more sourceAntiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer
Advanced Science, EarlyView.Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral +19 morewiley +1 more source
