Results 181 to 190 of about 29,370 (346)

Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma

Nature Communications
Tertiary lymphoid structures are immune cell aggregates linked with cancer outcomes, but their interactions with tumour cell aggregates are unclear. Using nasopharyngeal carcinoma as a model, here we analyse single-cell transcriptomes of 343,829 cells ...
Yang Liu, Shuang-Yan Ye, Shuai He, Dong-Mei Chi, Xiu-Zhi Wang, Yue-Feng Wen, Dong Ma, Run-Cong Nie, Pu Xiang, You Zhou, Zhao-Hui Ruan, Rou-Jun Peng, Chun-Ling Luo, Pan-Pan Wei, Guo-Wang Lin, Jian Zheng, Qian Cui, Mu-Yan Cai, Jing-Ping Yun, Junchao Dong, Hai-Qiang Mai, Xiaojun Xia, Jin-Xin Bei   +22 more
doaj   +1 more source

CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses [PDF]

, 2021
Kerstin Wennhold, Martin Thelen, Jonas Lehmann, Simon Schran, Ella Preugszat, María A. García-Márquez, Axel Lechner, Alexander Shimabukuro‐Vornhagen, Meryem S. Ercanoglu, Florian Klein, Fabinshy Thangarajah, Sebastian Eidt, Heike Löser, Christiane J. Bruns, Alexander Quaas, Michael von Bergwelt‐Baildon, Hans Schlößer   +16 more
openalex   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures [PDF]

, 2021
Roger Li, Anders Berglund, Logan Zemp, Jasreman Dhillon, Ryan M. Putney, Young‐Chul Kim, Rohit Jain, G. Daniel Grass, José R. Conejo-García, James J. Mulé   +9 more
openalex   +1 more source

Tertiary lymphoid structures are associated with favorable survival outcomes in patients with endometrial cancer [PDF]

, 2021
Meng Qin, Junzo Hamanishi, Masayo Ukita, Koji Yamanoi, Shiro Takamatsu, Kaoru Abiko, Ryusuke Murakami, Taito Miyamoto, Haruka Suzuki, Akihiko Ueda, Yuko Hosoe, Akihito Horie, Ken Yamaguchi, Masaki Mandai   +13 more
openalex   +1 more source

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

Supplementary Table 1 from Characterization of Chemokines and Adhesion Molecules Associated with T cell Presence in Tertiary Lymphoid Structures in Human Lung Cancer

, 2023
Luc de Chaisemartin, Jérémy Goc, Diane Damotte, Pierre Validire, Pierre Magdeleinat, Marco Alifano, Isabelle Cremer, Wolf H. Fridman, Catherine Sautès‐Fridman, Marie‐Caroline Dieu‐Nosjean   +9 more
openalex   +1 more source

Stratification of chronic rhinosinusitis with nasal polyps by distinct sinonasal microbial communities and their clinical and pathological correlations

iMetaOmics, EarlyView.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory condition. Dysbiosis is commonly observed. This study identified distinct sinonasal microbial communities in CRSwNP patients and explored their clinical and pathological associations. Two distinct microbial communities were identified: community type 1 (CT1), dominated by
Bixing Fang, Yanmin Liu, Qing Bao, Lin Sun, Hexin Chen, Qingxiang Meng, Linyi Jiao, Xiaoyan Ye, Jian Li, Tao Ding, Chunwei Li   +10 more
wiley   +1 more source

Most costly and prevalent reasons for hospitalization in children with medical complexity in Ontario, Canada

Journal of Hospital Medicine, EarlyView.
Abstract Background and Objectives Children with medical complexity (CMC) have chronic health conditions often associated with functional limitations. CMC comprise 1%–5% of the pediatric population. In Canada, their care accounts for one‐third of pediatric health spending.
Erin Hessey, Thaksha Thavam, Sanjay Mahant, Eyal Cohen, Jingqin Zhu, Francine Buchanan, Teresa To, Peter J. Gill, Ontario Pediatric Hospital Care Study Group (OPHCSG) and the Canadian Paediatric Inpatient Research Network (PIRN), Wenjia Chen, Ronald Cohn, Mairead Green, Matt Hall, Kate Langrish, Colin Macarthur, Myla Moretti, Patricia Parkin, Michelle Quinlan, Ann Bayliss, Ronik Kanani, Sean Murray, Catherine Pound, Mahmoud Sakran, Anupam Sehgal, Sepi Taheri, Gita Wahi   +25 more
wiley   +1 more source

Tertiary Lymphoid Structures, Immune Response, and Prognostic Relevance in Non-Small Cell Lung Cancer

, 2022
Alexandra Giatromanolaki, Paschalis Chatzipantelis, Constantinos Contrafouris, Michael I. Koukourakis   +3 more
openalex   +2 more sources