Results 1 to 10 of about 305,776 (233)

Source Tracking and Global Distribution of the Tigecycline Non-Susceptible tet(X) [PDF]

Microbiology Spectrum, 2021
The emergence of tet(X) genes has compromised the clinical use of the last-line antibiotic tigecycline. We identified 322 (1.21%) tet(X) positive samples from 12,829 human microbiome samples distributed in four continents (Asia, Europe, North America ...
Rong-min Zhang, Jian Sun, Ruan-yang Sun, Min-ge Wang, Chao-yue Cui, Liang-xing Fang, Mei-na Liao, Xiao-qing Lu, Yong-xin Liu, Xiao-Ping Liao, Ya-Hong Liu   +10 more
doaj   +4 more sources

MALDI-TOF MS for rapid detection and differentiation between Tet(X)-producers and non-Tet(X)-producing tetracycline-resistant Gram-negative bacteria [PDF]

Virulence, 2022
The extensive use of tetracycline antibiotics has led to the widespread presence of tetracycline-resistance genes in Gram-negative bacteria and this poses serious threats to human and animal health.
Zi-Jian Zheng, Ze-Hua Cui, Qiu-Yue Diao, Xin-Qing Ye, Zi-Xing Zhong, Tian Tang, Shuai-Bin Wu, Hui-Ling He, Xin-Lei Lian, Liang-Xing Fang, Xi-Ran Wang, Li-Jie Liang, Ya-Hong Liu, Xiao-Ping Liao, Jian Sun   +14 more
doaj   +5 more sources

Bismuth Drugs Reverse Tet(X)-Conferred Tigecycline Resistance in Gram-Negative Bacteria [PDF]

Microbiology Spectrum, 2022
Antibiotic resistance has caused a serious threat to public health and human safety. Recently, the emergence of novel resistance gene tet(X4) and its variants threatens the clinical utility of tigecycline, one of the last-line antibiotics for multidrug ...
Tian Deng, Yuqian Jia, Ziwen Tong, Jingru Shi, Zhiqiang Wang, Yuan Liu   +5 more
doaj   +4 more sources

Classification and molecular characteristics of tet(X)-carrying plasmids in Acinetobacter species [PDF]

Frontiers in Microbiology, 2022
The rapid dissemination of plasmid-mediated tet(X) genes in Acinetobacter species has compromised the clinical effectiveness of tigecycline, one of the last-resort antibiotics.
Chong Chen, Chong Chen, Chong Chen, Ping-Yu Huang, Ping-Yu Huang, Chao-Yue Cui, Qian He, Jian Sun, Jian Sun, Ya-Hong Liu, Ya-Hong Liu, Jin-Lin Huang, Jin-Lin Huang, Jin-Lin Huang   +13 more
doaj   +4 more sources

Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species [PDF]

Genome Medicine, 2020
Background The recent emergence and dissemination of high-level mobile tigecycline resistance Tet(X) challenge the clinical effectiveness of tigecycline, one of the last-resort therapeutic options for complicated infections caused by multidrug-resistant ...
Chong Chen, Chao-Yue Cui, Jun-Jun Yu, Qian He, Xiao-Ting Wu, Yu-Zhang He, Ze-Hua Cui, Cang Li, Qiu-Lin Jia, Xiang-Guang Shen, Ruan-Yang Sun, Xi-Ran Wang, Min-Ge Wang, Tian Tang, Yan Zhang, Xiao-Ping Liao, Barry N. Kreiswirth, Shi-Dan Zhou, Bin Huang, Hong Du, Jian Sun, Liang Chen, Ya-Hong Liu   +22 more
doaj   +5 more sources

Chlorogenic acid attenuates tet (X)-mediated doxycycline resistance of Riemerella anatipestifer [PDF]

Frontiers in Veterinary Science
IntroductionThe increasing resistance of R. anatipestifer has posed a significant threat to the poultry industry in recent years. The tet gene is the primary determinant of tetracycline resistance in numerous bacteria, and the enzyme modification gene ...
Yuwen Han, Min Li, Dehai Su, Shiyu Xiong, Youshu Feng, Qin Deng, Huanzhong Ding   +6 more
doaj   +4 more sources

Harnessing efficient multiplex PCR methods to detect the expanding Tet(X) family of tigecycline resistance genes [PDF]

Virulence, 2020
A growing number of tet(X)-type tigecycline resistance determinants [tet(X1) to tet(X5)] constitutes an expanding family of tetracycline-inactivating enzymes, posing a potential risk to global public health.
Kai Ji, Yongchang Xu, Jian Sun, Man Huang, Xu Jia, Chengjian Jiang, Youjun Feng   +6 more
doaj   +5 more sources

Occurrence and Molecular Characterization of Abundant tet(X) Variants Among Diverse Bacterial Species of Chicken Origin in Jiangsu, China [PDF]

Frontiers in Microbiology, 2021
Many novel tigecycline-inactivating enzymes encoded by tet(X) variants from different bacteria were discovered since the plasmid-mediated tet(X3) and tet(X4) genes conferring high-level resistance to tigecycline in Enterobacterales and Acinetobacter were
Yingshan Li, Yingshan Li, Kai Peng, Kai Peng, Yi Yin, Yi Yin, Xinran Sun, Xinran Sun, Wenhui Zhang, Wenhui Zhang, Ruichao Li, Ruichao Li, Ruichao Li, Zhiqiang Wang, Zhiqiang Wang   +14 more
doaj   +2 more sources

Deciphering the Structural Diversity and Classification of the Mobile Tigecycline Resistance Gene tet(X)-Bearing Plasmidome among Bacteria [PDF]

mSystems, 2020
The emergence of novel plasmid-mediated resistance genes constitutes a great public concern. Recently, mobile tet(X) variants were reported in diverse pathogens from different sources.
Ruichao Li, Xiaoyu Lu, Kai Peng, Ziyi Liu, Yan Li, Yuan Liu, Xia Xiao, Zhiqiang Wang   +7 more
doaj   +2 more sources

Genetic Characterization of the Tetracycline-Resistance Gene tet(X) Carried by Two Epilithonimonas Strains Isolated from Farmed Diseased Rainbow Trout, Oncorhynchus mykiss in Chile [PDF]

Antibiotics, 2021
The main objective of this study was to characterize the tet(X) genes, which encode a monooxygenase that catalyzes the degradation of tetracycline antibiotics, carried by the resistant strains FP105 and FP233-J200, using whole-genome sequencing analysis.
Christopher Concha, Claudio D. Miranda, Javier Santander, Marilyn C. Roberts   +3 more
doaj   +2 more sources