Results 31 to 40 of about 305,776 (233)

Threat and Control of <i>tet</i>(X)-Mediated Tigecycline-Resistant <i>Acinetobacter</i> sp. Bacteria. [PDF]

Foods
Tigecycline is regarded as one of the last-resort antibiotics against multidrug-resistant (MDR) Acinetobacter sp. bacteria. Recently, the tigecycline-resistant Acinetobacter sp. isolates mediated by tet(X) genes have emerged as a class of global pathogens for humans and food-producing animals. However, the genetic diversities and treatment options were
Chen C, Wu T, Liu J, Gao J.
europepmc   +3 more sources

Anti-HIV agent azidothymidine decreases Tet(X)-mediated bacterial resistance to tigecycline in Escherichia coli. [PDF]

Commun Biol, 2020
AbstractRecent emergence of high-level tigecycline resistance mediated by Tet(X3/X4) in Enterobacteriaceae undoubtably constitutes a serious threat for public health worldwide. Antibiotic adjuvant strategy makes antibiotic more effective against these resistant pathogens through interfering intrinsic resistance mechanisms or enhancing antibiotic ...
Liu Y, Jia Y, Yang K, Li R, Xiao X, Wang Z.   +5 more
europepmc   +4 more sources

Evolution in action: dissemination of tet(X) into pathogenic microbiota. [PDF]

Front Microbiol, 2013
In a recent publication by Leski et al. (2013), the authors reported the occurrence of multidrug-resistant tet(X)-containing bacterial strains in a hospital in Sierra Leone. Among 52 clinical isolates, 11 (21%) have been confirmed tet(X)-positive. All the positive strains have been isolated from urinary tract infections and identified as Enterobacter ...
Aminov RI.
europepmc   +5 more sources

Emergence of a novel high-level tigecycline resistance gene <i>tet</i>(X6) variant coexisting with <i>tet</i>(X2) and two <i>tet</i>(X) copies in a <i>Sphingobacterium</i> sp. [PDF]

Antimicrob Agents Chemother
Xu Q, Hou J, Schwarz S, Chai J, Lin L, Ma C, Zhu Y, Zhang W.   +7 more
europepmc   +3 more sources

Plasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli. [PDF]

Nat Microbiol, 2019
Tigecycline is one of the last-resort antibiotics to treat complicated infections caused by both multidrug-resistant Gram-negative and Gram-positive bacteria1. Tigecycline resistance has sporadically occurred in recent years, primarily due to chromosome-encoding mechanisms, such as overexpression of efflux pumps and ribosome protection2,3.
Sun J, Chen C, Cui CY, Zhang Y, Liu X, Cui ZH, Ma XY, Feng Y, Fang LX, Lian XL, Zhang RM, Tang YZ, Zhang KX, Liu HM, Zhuang ZH, Zhou SD, Lv JN, Du H, Huang B, Yu FY, Mathema B, Kreiswirth BN, Liao XP, Chen L, Liu YH.   +24 more
europepmc   +4 more sources

Sporadic Dissemination of tet(X3) and tet(X6) Mediated by Highly Diverse Plasmidomes among Livestock-Associated Acinetobacter

Microbiology Spectrum, 2021
The emergence of high-level tigecycline resistance mediated by plasmid-borne tet(X) genes greatly threatens the clinical effectiveness of tigecycline. However, the dissemination pattern of plasmid-borne tet(X) genes remains unclear. We here recovered tet(
Ying-Ying Cheng, Yang Liu, Yong Chen, Fu-Man Huang, Rong-Chang Chen, Yong-Hong Xiao, Kai Zhou   +6 more
doaj   +1 more source

Multidrug-resistant tet(X)-containing hospital isolates in Sierra Leone [PDF]

International Journal of Antimicrobial Agents, 2013
The tet(X) gene encodes a flavin-dependent monooxygenase that confers resistance to all clinically relevant tetracycline antibiotics including tigecycline. It has only previously been identified in environmental and non-human pathogenic bacteria. To investigate levels of multidrug resistance in Bo, Sierra Leone, a molecular epidemiological study was ...
Leski, Tomasz A, Bangura, Umaru, Jimmy, David Henry, Ansumana, Rashid, Lizewski, Stephen E, Stenger, David A, Taitt, Chris Rowe, Vora, Gary J   +7 more
openaire   +2 more sources

Detection of a new tet(X6)-encoding plasmid in Acinetobacter towneri

Journal of Global Antimicrobial Resistance, 2021
: Objectives: The aim of this study was to characterise a novel tet(X6)-carrying plasmid detected in a livestock-associated Acinetobacter towneri isolate.
Yingying Cheng, Yong Chen, Yang Liu, Jingjie Song, Yunbo Chen, Tongling Shan, Yonghong Xiao, Kai Zhou   +7 more
doaj   +1 more source

Multiple Mechanisms of Tigecycline Resistance in Enterobacteriaceae from a Pig Farm, China

Microbiology Spectrum, 2021
We isolated eight tigecycline-resistant Enterobacteriaceae strains from a pig farm in Shanghai, China, including Escherichia coli (n = 1), Proteus cibarius (n = 1), and Enterobacter hormaechei (n = 6). Two of them (E. coli and P.
Jing Wang, Han Wu, Cai-Yue Mei, Yan Wang, Zhen-Yu Wang, Meng-Jun Lu, Zhi-Ming Pan, Xinan Jiao   +7 more
doaj   +1 more source

Co-occurrence of two tet(X) variants in an Empedobacter brevis of shrimp origin. [PDF]

Antimicrob Agents Chemother, 2019
Emerging novel resistance mechanisms pose a great public health concern.….
Li R, Liu Z, Peng K, Liu Y, Xiao X, Wang Z.   +5 more
europepmc   +4 more sources