Results 21 to 30 of about 54,573 (154)

Emerging Opportunity and Destiny of mcr-1- and tet(X4)-Coharboring Plasmids in Escherichia coli [PDF]

Microbiology Spectrum, 2021
The emergence of the plasmid-mediated colistin resistance gene mcr-1 and the plasmid-mediated tigecycline resistance gene tet(X4) represents a significant threat to public health.
Xiaoyu Lu, Xia Xiao, Yuan Liu, Ruichao Li, Zhiqiang Wang   +4 more
doaj   +4 more sources

Comprehensive Genomic Investigation of Tigecycline Resistance Gene tet(X4)-Bearing Strains Expanding among Different Settings [PDF]

Microbiology Spectrum, 2021
The emergence of plasmid-mediated tigecycline resistance genes has attracted a great deal of attention globally. Currently, no comprehensive in-depth genomic epidemiology study of tet(X4)-bearing pathogens present of pork origin as the One Health ...
Ruichao Li, Yan Li, Kai Peng, Yi Yin, Yuan Liu, Tao He, Li Bai, Zhiqiang Wang   +7 more
doaj   +5 more sources

The ISVsa3-ORF2-abh-tet(X4) circular intermediate-mediated transmission of tigecycline resistance in Escherichia coli isolates from duck farms [PDF]

Frontiers in Cellular and Infection Microbiology
Tigecycline is a last-resort drug used to treat serious infections caused by multidrug-resistant bacteria. tet(X4) is a recently discovered plasmid-mediated tigecycline resistance gene that confers high-level resistance to tigecycline and other ...
Chao Jiang, Chao Jiang, Jie Yang, Jie Yang, Gang Xiao, Gang Xiao, Ning Xiao, Ning Xiao, Jie Hu, Yi Yang, Zhiliang Sun, Zhiliang Sun, Yujuan Li, Yujuan Li, Yujuan Li   +14 more
doaj   +3 more sources

Characterization of an Escherichia coli Isolate Coharboring the Virulence Gene astA and Tigecycline Resistance Gene tet(X4) from a Dead Piglet [PDF]

Pathogens, 2023
tet(X4) is the critical resistance gene for tigecycline degradation that has been continually reported in recent years. In particular, pathogenic bacteria carrying tet(X4) are a severe threat to human health.
Jianmei Wang, Yuting Huang, Chunjiu Guan, Jie Li, Hua Yang, Guoping Zhao, Canying Liu, Jiangang Ma, Biao Tang   +8 more
doaj   +3 more sources

Emergence of plasmid-borne tet(X4) resistance gene in clinical isolate of eravacycline- and omadacycline-resistant Klebsiella pneumoniae ST485 [PDF]

Microbiology Spectrum
Omadacycline and eravacycline are gradually being used as new tetracycline antibiotics for the clinical treatment of Gram-negative pathogens. Affected by various tetracycline-inactivating enzymes, there have been reports of resistance to eravacycline and
Xiaojing Liu, Yi Liu, Xiaohan Ma, Ruyan Chen, Chenyu Li, Hongxin Fu, Yu Yang, Kexin Guo, Xiaoping Zhang, Ruishan Liu, Hao Xu, Junfei Zhu, Beiwen Zheng   +12 more
doaj   +3 more sources

Community gut colonization by tet(X4)-positive multidrug-resistant Escherichia coli in healthy individuals from urban residents in Shenzhen, China [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundTigecycline remains a last-resort antibiotic for treating multidrug-resistant (MDR) Gram-negative pathogens. The emergence of tet(X4)-mediated high-level tigecycline resistance in Escherichia coli has raised global concern, yet its prevalence ...
Ruoyan Peng, Pei Liang, Wenxiao Jiang, Zhaodong Li, Li Wang, Yi Huang, Xianfang Zhang, Yijia Guo, Ying Wang, Jing Wang, Jiubiao Guo, Feifei Yin, Dachuan Lin   +12 more
doaj   +3 more sources

Characteristics of tet(X4)−Producing Escherichia coli in Chicken and Pig Farms in Hunan Province, China [PDF]

Antibiotics, 2023
Background: The plasmid−mediated tigecycline resistance gene tet(X4) confers a high level of resistance to tigecycline. The experiment aims to investigate the prevalence and characterization of tet(X4) in Escherichia coli isolates from chicken and pig ...
Jie Yang, Gang Xiao, Ning Xiao, Zonghan Jiang, Chao Jiang, Yujuan Li, Wenxin Chen, Hongguang Lin, Zhiliang Sun, Jiyun Li   +9 more
doaj   +4 more sources

A promising metabolite, 9-aminominocycline, restores the sensitivity of tigecycline against tet(X4)-positive Escherichia coli. [PDF]

Front Microbiol
The emergence and widespread of tigecycline resistance undoubtedly poses a serious threat to public health globally. The exploration of combination therapies has become preferred antibacterial strategies to alleviate this global burden.
Sun F, Zhang L, Ma X, Ali T, Wu Y, Li L.
europepmc   +5 more sources

Transcriptomic Analysis of the Impact of the tet(X4) Gene on the Growth Characteristics and Antibiotic Resistance Phenotypes of Escherichia coli Isolated from Musk Deer [PDF]

Animals
Escherichia coli (E. coli) is a ubiquitous opportunistic pathogen in nature and serves as an important reservoir for antibiotic resistance genes. The tet(X4) gene is a key determinant mediating tigecycline resistance.
Kaiwei Yang, Xi Wu, Bingcun Ma, Jianguo Cheng, Zengting Li, Yin Wang, Zexiao Yang, Xueping Yao, Yan Luo   +8 more
doaj   +3 more sources

Comparison of tet(X4)-containing contigs assembled from metagenomic sequencing data with plasmid sequences of isolates from a cohort of healthy subjects [PDF]

Microbiology Spectrum
Recently discovered tet(X) gene variants have provided new insights into microbial antibiotic resistance mechanisms and their potential consequences for public health.
Yichen Ding, Shuan Er, Abel Tan, Jean-Sebastien Gounot, Woei-Yuh Saw, Linda Wei Lin Tan, Yik Ying Teo, Niranjan Nagarajan, Henning Seedorf   +8 more
doaj   +3 more sources