Results 101 to 110 of about 13,139 (196)

Tetrahydrobiopterin protects phenylalanine hydroxylase activity in vivo: Implications for tetrahydrobiopterin‐responsive hyperphenylalaninemia

, 2004
The natural cofactor of phenylalanine hydroxylase (PAH), tetrahydrobiopterin (BH4), regulates the enzyme activity as well as being essential in catalysis. BH4-responsive PAH deficiency is a variant of hyperphenylalaninemia or phenylketonuria (PKU) caused
Beat Thöny, Aurora Martı́nez, Zhaobing Ding, Martínez A, Ding Z, Thöny B   +5 more
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Beneficial Role of Tetrahydrobiopterin on Various Cardiovascular Diseases and Regulation of its Levels under Pathological Conditions

Pteridines, 2006
5,6,7,8-Tetrahydrobiopterin (BH4) is an csscntial cofactor for production of nitric oxide (NO) by N O synthase (NOS). Nitric oxide (NO) is an important signaling mo!ecu!e for the regulation o f vita! functions such as vascular tone, neurotransmission and
Shimizu Shunichi, Ishii Masakazu, Wajima Teruaki, Hagiwara Tamio, Negoro Takaharu   +4 more
doaj   +1 more source

Loss of striatal dopaminergic fibers after intraventricular injection of tetrahydrobiopterin in rat brain

, 2004
We have reported previously that tetrahydrobiopterin (BH4), an obligatory cofactor for dopamine synthesis, exerts preferential toxicity on dopamine producing cells.
장진우
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The roles of Ca2+ and the Ca2+-sensing receptor (CASR) in the expression of inducible NOS (nitric oxide synthase)-2 and its BH4 (tetrahydrobiopterin)-dependent activation in cytokine-stimulated adult human astrocytes.

, 2005
The roles of Ca2+ and the Ca2+-sensing receptor (CASR) in the expression of inducible NOS (nitric oxide synthase)-2 and its BH4 (tetrahydrobiopterin)-dependent activation in cytokine-stimulated adult human ...
E. Nemeth, DAL PRÀ, Ilaria Pierpaola, CHIARINI, Anna Maria, ARMATO, Ubaldo, J. F. Whitfield   +4 more
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Gene transfer as a potential treatment for tetrahydrobiopterin deficient states. [PDF]

, 2007
Tetrahydrobiopterin (BH4) is an essential cofactor for dopamine (DA), noradrenaline (NA), serotonin and nitric oxide (NO) synthesis in the brain. Inborn errors of BH4 metabolism including GTP cyclohydrolase 1 (GTP-CH) deficiency are debilitating diseases
Foxton, R.
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Unlocking The Efficacy of Tetrahydrobiopterin (BH4) Towards Metabolic Profile and Growth Status in Children with Phenylketonuria: A Meta Analysis [PDF]

Background: Phenylketonuria (PKU) is one of the most common types of inborn error of metabolism. Low-phenylalanine diet has been the main treatment for children with PKU.
Anggie Lorenza, Naoval Diza Ananda, Nur Aisiyah Widjaja, Rafi Alfian Razan, Vianca Samara Andhary   +4 more
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A Study on Tetrahydrobiopterin and Associated Enzyme Activities n Rat Livers

, 2010
Tetrahydrobiopterin（5,6,7,8-tetrahydropterin，BH4）為人體的內生性物質，具有多重重要功能，特別是在神經傳導物質catecholamines和 serotonin的生合成中，扮演著必要的調控因子。此外，BH4也是體內三種芳香性胺基酸水解酶phenylalanine hydroxylase、tyrosine hydroxylase和tryptophan hydroxylase的輔酶。體內缺乏 BH4，導致體內 neurotransmitters缺少時 ...
Lin, Chia-Chun, 林嘉均
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CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.

, 2008
BACKGROUND: Vascular injury results in loss of endothelial nitric oxide (NO), production of reactive oxygen species (ROS), and the initiation of an inflammatory response.
Bursill, CA, Channon, Keith, Douglas, G, Ali, ZA, Bendall, JK, Papaspyridonos, M, Akhtar, AM, Alp, NJ, Greaves, David, McNeill, E, Tatham, AL   +10 more
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No effect of acute tetrahydrobiopterin (BH₄) supplementation on vascular dysfunction in the old.

J Appl Physiol (1985), 2022
Bisconti AV, Garten RS, Broxterman RM, Jarrett CL, Park SH, Shields KL, Clifton HL, Ratchford SM, Reese V, Zhao J, Wray DW, Richardson RS.   +11 more
europepmc   +1 more source

Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency in Dutch neonates

, 2001
Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency in Dutch neonates. Spaapen LJ, Bakker JA, Velter C, Loots W, Rubio-Gonzalbo ME, Forget PP, Dorland L, De Koning TJ, Poll-The BT, Ploos van Amstel HK, Bekhof J, Blau N, Duran M ...
M. E. Rubio‐Gonzalbo, Rubio-Gonzalbo, M. E., Forget, Ph., Duran, M., J. A. Bakker, M. Duran, Bakker, J.A., Blau, N., B. T. Poll‐The, Forget, P. P., C. Velter, T. J. De Koning, Bakker, J. A., van Ploos Amstel, H.K., N. Blau, L. J. M. Spaapen, L. Dorland, Poll-The, B. T., Bekhof, J., W. Loots, P. P. Forget, H. K. Ploos Van Amstel, de Koning, T.J., Rubio-Gozalbo, M.E., Spaapen, L.J.M., Velter, C., Loots, W., the Poll, B.T., J. Bekhof, Dorland, L., Spaapen, L. J. M., De Koning, T. J., Ploos Van Amstel, H. K.   +32 more
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