Results 81 to 90 of about 13,139 (196)

Stimulation of hepatic phenylalanine hydroxylase activity but not Pah-mRNA expression upon oral loading of tetrahydrobiopterin in normal mice.

, 2005
Tetrahydrobiopterin (BH4) supplementation in patients with BH4-responsive phenylalanine hydroxylase (PAH) deficiency is an alternative to low-phenylalanine diet.
Blau N, Martínez A, Ding Z, Haavik J, Scavelli R, Thöny B   +5 more
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Troglitazone Stimulates the Insulin-induced Tetrahydrobiopterin Synthesis In Vascular Endothelial Cells

Pteridines, 2000
We investigated the effects of troglitazone, which is a ligand of nuclear transcription factor peroxisome proliferator- activated receptor-γ (PPAR-γ), on insulin-induced tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells ...
Ishii Masakazu, Shimizu Shunichi, Shiota Kazuhiro, Kiuchi Yuji, Yamamoto Toshinori   +4 more
doaj   +1 more source

Genotype-predicted tetrahydrobiopterin (BH4)-responsiveness and molecular genetics in Croatian patients with phenylalanine hydroxylase (PAH) deficiency

, 2009
Specific mutations in the gene encoding phenylalanine hydroxylase (PAH), located on chromosome 12q22-24.1, are linked to tetrahydrobiopterin (BH4; sapropterin)-responsive phenylketonuria (PKU).
Sarnavka, V, Petkovic Ramadza, D, Heintz, C, Karacic, I, Mardesic, D, Meili, D, Thony, B; https://orcid.org/, Fumic, K, Baric, I, Blau, N   +9 more
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Chapter 10: Tetrahydrobiopterin: An Essential Cofactor of Nitric Oxide Synthase with an Elusive Role

, 2000
This chapter surveys the roles of pterins in biology and provides an understanding of biochemical pathways that determine tetrahydrobiopterin (BH4) levels in mammalian cells and how they are regulated.
Smith, C.L.
core  

Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure.

, 2011
The exogenous administration of tetrahydrobiopterin (BH4), an essential cofactor of nitric oxide synthase (NOS), has been shown to reduce left ventricular hypertrophy, fibrosis, and cardiac dysfunction in mice with pre-established heart disease induced ...
Michael S. Wolin, O'Neill, Charles A., Elizabeth A. Ketner, Channon, Keith M., Ketner, Elizabeth A., Kass, David A., Charles A. O'Neill, David A. Kass, Takimoto, Eiki, Eiki Takimoto, Tim S. Schmidt, Keith M. Channon, Schmidt, Tim S., An L. Moens, Moens, An L., Nicholas J. Alp, Wolin, Michael S., Alp, Nicholas J.   +17 more
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Study on the Pteridines Metabolism in Children Affected by Hyperphenylalaninaemia and Phenylketonuria

Pteridines, 1989
Atypical phenylketonuria (PKU) is caused by tetrahydrobiopterin (BH4) deficiency. In Italy a systematic screening service for BH4 deficiency is not currently performed, therefore its real frequency is not known yet.
Valsasina R., Riva E., Biasucci G., Longhi R., Giovannini M.   +4 more
doaj   +1 more source

Investigation of a potential role for aldose reductase AlrA in tetrahydropteridine synthesis in Dictyostelium discoideum Ax2

Pteridines, 2017
Dictyostelium discoideum Ax2 is well-known for the synthesis of d-threo-tetrahydrobiopterin (DH4) with a smaller amount of l-erythro-tetrahydrobiopterin (BH4).
Kim Hye-Lim, Ryu Hyun-Chul, Park Young Shik   +2 more
doaj   +1 more source

Glucocorticoids Inhibit Tetrahydrobiopterin-Dependent Endothelial Function

, 2001
Tetrahydrobiopterin (BH4) acts as an important co-factor for endothelial nitric oxide synthase (eNOS). Glucocorticoids have been shown to inhibit expression of the rate-limiting enzyme for tetrahydrobiopterin synthesis, GTP cyclohydrolase, in other cell
Douglas G. Johns, Anne M. Dorrance, R. Clinton Webb, Nicole L. Tramontini   +3 more
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A New Functional Role of 5,6,7,8-tetrahydrobiopterin (BH4) as an Inhibitor of γ-glutamylcysteine Synthetase (γ-GCS) mRNA Expression

Pteridines, 2002
The effect of the intracellular 5,6,7,8-tetrahydrobiopterin (BH4) on the increased γ-glutamylcysteine synthetase (γ-GCS) mRNA expression induced by nitric oxide (NO) was investigated in RAW264.7 cells.
Kojima Shuji, Kurozumi Risa, Tuchiya Maiko   +2 more
doaj   +1 more source

Effects of tetrahydrobiopterin and tempol on acetylcholine-dilation in APL3W, CT3W and HCQ3W.

, 2018
Effects of tetrahydrobiopterin (BH4) and Tempol on dilation responses expressed as percentage of relaxation to acetylcholine (ACh) in mice mesenteric arteries.
Cristina Belizna (5937986), Caroline Poli (3155322), Marc-Antoine Begorre (5937983), Geoffrey Urbanski (5937977), Daniel Henrion (431681), Gilles Kauffenstein (436349), Laurent Loufrani (431680), Antoine Caillon (5937980)   +7 more
core   +1 more source