Results 91 to 100 of about 13,139 (196)

Role of endothelial colony forming cells (ECFCs) Tetrahydrobiopterin (BH4) in determining ECFCs functionality in coronary artery disease (CAD) patients. [PDF]

Sci Rep, 2022
Sen A, Singh A, Roy A, Mohanty S, Naik N, Kalaivani M, Ramakrishnan L.   +6 more
europepmc   +1 more source

Tetrahydrobiopterin and Endothelial Dysfunction in Cardiovascular Diseases

Pteridines, 2006
Endothelial vasodilator dysfunction is a characteristic feature of patients at risk for coronary atheroscierosis. We have reported that insulin resistance may be a pathogenic factor for endothehal dysfunction through impaired endothelial nitric oxide ...
Shinozaki Kazuya, Kashiwagi Atsunori, Masada Masahiro, Okamura Tomio   +3 more
doaj   +1 more source

Data on phenylalanine-to-tyrosine ratios in assessment of tetrahydrobiopterin (BH₄)-responsiveness in patients with hyperphenylalaninemia. [PDF]

Data Brief, 2022
Lampret BR, Tansek MZ, Groselj B, Sikonja J, Battelino T, Groselj U.   +5 more
europepmc   +1 more source

Regulation of Tetrahydrobiopterin (BH4) Synthesis in the Nematode C. elegans

The FASEB Journal, 2018
5,6,7,8‐tetrahydrobiopterin (BH4) is a cofactor required by the aromatic amino acid hydroxylases (AAAHs), nitric oxide synthases, and alkylglycerol monooxygenase (Werner et al., 2011, Biochem. J. 438: 397). Among the AAAHs are the rate‐limiting synthetic enzymes for serotonin and dopamine synthesis, and for conversion of ...
Tatiana Moreno, Curtis Loer
openaire   +1 more source

Utility of Tetrahydrobiopterin Pathway in the Assessment of Diabetic Foot Ulcer: Significant and Complex Interrelations

Journal of Diabetes Research, 2019
Objectives. Tetrahydrobiopterin (BH4) pathway that included generation of neopterin (Neop), biopterin (Biop), and nitric oxide (NO) is altered in type 2 diabetes (T2D). The aim of this study was to assess the biomarkers of BH4 pathway in noninfected DFUs
Marwan Al-Nimer, Rawa Ratha, Taha Mahwi
doaj   +1 more source

Massive parallel sequencing as a new diagnostic approach for phenylketonuria and tetrahydrobiopterin-deficiency in Thailand

BMC Medical Genetics, 2017
Background Hyperphenylalaninemia (HPA) can be classified into phenylketonuria (PKU) which is caused by mutations in the phenylalanine hydroxylase (PAH) gene, and BH4 deficiency caused by alterations in genes involved in tetrahydrobiopterin (BH4 ...
Pongsathorn Chaiyasap, Chupong Ittiwut, Chalurmpon Srichomthong, Apiruk Sangsin, Kanya Suphapeetiporn, Vorasuk Shotelersuk   +5 more
doaj   +1 more source

Tetrahydrobiopterin (bh4) supplementation prevents the cardiorenal effects of diabetes in mice by reducing oxidative stress, inflammation and fibrosis [PDF]

, 2022
Background: The effects of diabetes on the cardiovascular system as well as in the kidney are profound, which include hypertrophy and fibrosis. Diabetes also induces oxidative stress, at least in part due to the uncoupling of nitric oxide synthase (NOS)
Soto, Karen, Valdés, Cristian, Novoa, Ulises, Treuer, Adriana V., González, Daniel R., Villaseñor, Jorge   +5 more
core  

Intracranial calcification in dihydropteridine reductase deficiency

The Turkish Journal of Pediatrics, 1990
We described the clinical status and computerized tomographic findings of two patients with tetrahydrobiopterin (BH4) deficiency due to impaired BH4 regeneration.
T Coşkun, A Besim, I Ozalp, M Eryilmaz
doaj  

Tetrahydrobiopterin and Autism Spectrum Disorder: A Systematic Review of a Promising Therapeutic Pathway

Brain Sciences
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by persistent deficits in social communication and interaction, along with restricted and repetitive patterns of behavior, interests, or activities.
Clóvis Colpani Filho, Lucas Melfior, Sthephanie Luiz Ramos, Mateus Santos Oliveira Pizi, Lilian Freitas Taruhn, Margrit Ellis Muller, Thiago Kucera Nunes, Luísa de Oliveira Schmitt, Joana Margarida Gaspar, Miguel de Abreu de Oliveira, Giovanna Tassinari, Luisa Cruz, Alexandra Latini   +12 more
doaj   +1 more source

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.

, 2016
In vascular disease states such as atherosclerosis and diabetes, endothelial nitric oxide (NO) bioactivity is reduced and oxidative stress is increased, resulting in endothelial dysfunction.

core   +1 more source