Results 71 to 80 of about 13,139 (196)

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Nitric Oxide in Cancer: Mechanisms, Dual Role, and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Nitric oxide exerts concentration‐dependent dual roles in cancer, functioning as either a tumor promoter or suppressor. This review comprehensively examines NO's multifaceted regulation of tumor biology, including S‐nitrosylation signaling, metabolic reprogramming, immunemodulation, and therapy resistance, and highlights emerging therapeutic strategies
Jia Shao, Honghua Zhang, Jingyu Chen, Ziyu Qian, Ning Zhang, Yihua Zhang, Hui Ye, Jianbing Wu, Zhangjian Huang   +8 more
wiley   +1 more source

6R-L-erythro-Tetrahydrobiopterin Triggers Serotonin Release with 5HT-loaded RBL2H3 Cells, a Rat Mast Cell Line

Pteridines, 1999
A new function of tetrahydrobiopterin (BH4) was demonstrated in vitro in which BH4 stimulated serotonergic cells to release serotonin (5HT). RBL2H3 cells were pre-loaded with serotonin at 100 μM for 6 hours.
Nakazawa Naomi, Yamamoto Kazumasa, Nagano Mutsumi, Oguro Kazuya, Nakanishi Nobuo, Hasegawa Hiroyuki   +5 more
doaj   +1 more source

Catalytic Nitric Oxide‐Generating Selenium Nanoparticle‐Loaded Hydrogels With Anti‐Inflammatory and Pro‐Wound‐Healing Properties

Small Science, Volume 6, Issue 9, September 2026.
Polydopamine‐coated selenium nanoparticle (Se@PDA)‐loaded hydrogels enable sustained and tunable catalytic nitric oxide (NO) generation from S‐nitrosoglutathione (GSNO). The hydrogels exhibit excellent stability, recyclability, and biocompatibility, while elevating IL‐10 expression in endothelial cells and smooth muscle cells and increasing α‐SMA ...
Shu Geng, Kang Lin, Qingqing Fan, Yulong Sun, Federico Mazur, Rona Chandrawati   +5 more
wiley   +1 more source

Tetrahydrobiopterin deficiencies in the Maltese population [PDF]

, 2002
A higher than usual frequency of hyperphenylalaninaemia due to tetrahydrobiopterin (BH4) deficiencies, specifically Dihydropteridine Reductase (DHPR) deficiency, is present in the Maltese population.
34th ESHG Conference, Naudi, R., Scerri, Christian A., Felice, A. E., Farrugia, Rosienne, Attard Montalto, S., Bartolo, C., Parascandolo, Raymond   +7 more
core  

Modulation of pulmonary vascular tone by novel analogues of tetrahydrobiopterin

, 2005
Tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthase (NOS), is a highly polar and unstable molecule, which is subject to autooxidation, which ultimately leads to superoxide production.
Kununthur, S.R., Wadsworth, R.M., Gibson, C.L., Suckling, C.J.   +3 more
core   +2 more sources

Topical Donepezil for Cholinergic Modulation in Chronic Wound Repair

Wound Repair and Regeneration, Volume 34, Issue 5, September/October 2026.
ABSTRACT Chronic wounds result from combined defects in vascular perfusion, inflammatory resolution, and epithelial repair. The skin's non‐neuronal cholinergic system (NNCS), formed by keratinocytes, endothelial cells, fibroblasts, and immune cells that synthesise and respond to acetylcholine (ACh), helps coordinate these processes through muscarinic ...
Hui‐Qi Qu, Charlly Kao, Hakon Hakonarson   +2 more
wiley   +1 more source

Defining tetrahydrobiopterin (BH₄)‐responsiveness in PKU [PDF]

Journal of Inherited Metabolic Disease, 2008
# SSIEM and Springer 2007 BH4-responsive hyperphenylalaninaemia (HPA) is a recently described variant of phenylalanine hydroxylase (PAH) deficiency caused by specific mutations in the PAH gene. Diagnosis is performed by the tetrahydrobiopterin (BH4) loading test (20 mg/kg body weight) and the overall prevalence of BH4-responsiveness within patients ...
openaire   +1 more source

Tetrahydrobiopterin Synthesis in Rat Cardiac Myocytes; An Event Required for Cytokine-induced NO Generation

Pteridines, 1998
Cardiac myocytes are known to express the high-capacity inducible isoform of nitric oxide (NO) synthase (iNOS). Since tetrahydrobiopterin (BH4) is an essential cofactor for NO formation, we investigated whether BH4 synthesis is required for cytokine ...
Hattori Yoshiyuki, Nakanishi Nobuo, Gross Steven S., Kasai Kikuo   +3 more
doaj   +1 more source

Developmental and Phenotypic Outcomes in Mild Phenylalanine Hydroxylase Deficiency

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1814-1820, August 2026.
ABSTRACT Benign hyperphenylalaninemia (bHPA) is defined as elevated phenylalanine (Phe) levels remaining ≤ 360 μmol/L (6 mg/dL) and not requiring medical intervention. Individuals with bHPA may demonstrate a rise in their Phe levels > 360 μmol/L, effectively developing a mild PKU phenotype requiring therapy to prevent neurocognitive complications. This
Aaron Williams, Kristian Divin, Lindsay C. Burrage, William J. Craigen, Fernando Scaglia, Claudia Soler‐Alfonso, V. Reid Sutton, Kevin E. Glinton, Ronit Marom   +8 more
wiley   +1 more source