Results 61 to 70 of about 13,139 (196)

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, Volume 9, Issue 10, Page 1964-1981, October 2026.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

Molecular and Cellular Underpinnings of Primary Hypertension: An Integrative Mechanistic Framework

Journal of Cellular Physiology, Volume 241, Issue 10, October 2026.
ABSTRACT Hypertension is a highly prevalent clinical condition and a major contributor to global cardiovascular morbidity and mortality. Despite extensive research, its complex and multifaceted pathogenesis is yet to be fully elucidated. This paper explores the updated understanding of primary hypertension as a systemic disorder rather than an isolated
Dima Nasrallah, Alaa Abdelhamid, Omar Tluli, Yaman Al‐Haneedi, Mera Abu Hussien, Ali H. Eid   +5 more
wiley   +1 more source

Insulin Secretion in Response to L-Arginine under Decreasing Tetrahydrobiopterin Content

Pteridines, 2008
Tetrahydrobiopterin (BH4) content in the pancreas from GK (Goto-Kakizaki) rats as a type II diabetic model was markedly decreased compared to Wistar rats as a healthy control. Moreover, insulin stimulated BH4 synthesis in a hamster pancreatic β-cell line,
Ishii Masakazu, Shimizu Shunichi, Watabe Tatsuya, Kiuchi Yuji   +3 more
doaj   +1 more source

Coinfections Dampen the Effects of Temperature on Host–Parasite Interactions

Ecology Letters, Volume 29, Issue 10, October 2026.
Temperature can drive large shifts in host–parasite interactions, but these shifts need not correspond to strong effects on coinfecting parasite interactions. Coinfection may provide a stabilizing effect on disease in a warming world—but this effect can falter when hosts are faced with multiple stressors.
I. Will, C. A. Smith, T. E. Hector, K. C. King   +3 more
wiley   +1 more source

Functional analysis of sepiapterin reductase in Drosophila melanogaster

Pteridines, 2015
Sepiapterin reductase (SR) is a key enzyme involved in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for the synthesis of important biogenic amines, including catecholamines and serotonin.
Kim Kiyoung, Kim Heuijong, Yim Jeongbin
doaj   +1 more source

Behavioral Phenotyping of the Pahenu2 Mouse Model for Phenylketonuria—A Scoping Review and Future Perspectives

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Phenylketonuria (PKU) is a rare metabolic disorder resulting from a mutation in the gene encoding the enzyme phenylalanine hydroxylase (PAH), resulting in very high phenylalanine (Phe) levels in blood and brain. A PKU mutant mouse model was developed via N‐ethyl‐N‐nitrosourea (ENU) mutagenesis, mimicking the high brain Phe content seen in ...
Junfei Cao, Lennart Kruizinga, Iris B. Hovens, Els van der Goot, Robbert Havekes, Eddy A. van der Zee   +5 more
wiley   +1 more source

Nitrocatechols versus nitrocatecholamines as novel competitive inhibitors of neuronal nitric oxide synthase: lack of the aminoethyl side chain determines loss of tetrahydrobiopterin-antagonizing properties.

, 2002
6-Nitrocatecholamines were recently described as novel neuronal nitric oxide synthase inhibitors competing with both L-arginine and tetrahydrobiopterin (BH4).
PALUMBO ANNA, NAPOLITANO A., M. D'ISCHIA, NAPOLITANO, ALESSANDRA, D'ISCHIA, MARCO   +4 more
core   +1 more source

A Case of Dihydropteridine Reductase Deficiency

Pteridines, 2000
Tetrahydrobiopterin (BH4) is the essential cofacter of phenylalanine (Phe), tyrosine (Tyr), and tryptophan (Trp) hydroxylases . BH4 deficiency, a rare but severe type of hyperphenylalaninemia, is characterized by progressive neurologic symptoms despite ...
Furujo Mahoko, Ichiba Yozo, Sintaku Haruo, Asada Minoru   +3 more
doaj   +1 more source

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

Degeneration of the nigrostriatal pathway and induction of motor deficit by tetrahydrobiopterin: an in vivo model relevant to Parkinson’s disease

Neurobiology of Disease, 2003
We determined whether the preferential toxicity of tetrahydrobiopterin (BH4) on dopamine-producing cells, which we have previously observed in vitro, might also occur in vivo and generate characteristics associated with Parkinson’s disease. Intrastriatal
Seong Who Kim, Yeon Joo Jang, Jin Woo Chang, Onyou Hwang   +3 more
doaj   +1 more source