Results 41 to 50 of about 13,139 (196)

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Serum Biopterin as a Marker of Immune Activation in the Spontaneously Diabetic BB Rat

Pteridines, 1998
Tetrahydrobiopterin (BH4), is a pteridine product which is released by rodent macrophages and fibroblasts upon activation by cytokines. It has previously been reported as a potentially useful marker for monitoring immune activation during the prediabetic
Galloway Tamara, Braven Jim, Barley Jas, Rokos Hartmut, Wilkin Terence   +4 more
doaj   +1 more source

Illuminating Streptomyces: Raman Spectroscopy for Antibiotic Detection and Monitoring

Journal of Raman Spectroscopy, EarlyView.
Raman spectroscopy provides a non‐destructive, label‐free approach for studying the chemical diversity of Streptomyces. This review presents its application from detection to chemical characterization of secondary metabolites and monitoring of biosynthetic processes.
Adéla Mikulová, Jan Bobek, Martin Kizovský, Markéta Benešová, Ota Samek, Pavlína Modlitbová, Zdeněk Pilát   +6 more
wiley   +1 more source

Control of Melanogenesis In the Human Epidermis by the Redox-Status of Tetrahydrobiopterins

Pteridines, 1995
Activity of tyrosinase directly controls melanogenesis in the human epidermis. Recently, it has been shown that the biosynthesis and recycling of (6R)L-erythro 5,6,7,8 tetrahydrobiopterin (6-BH4) plays a central role in regulating the supply of L ...
Schallreuter-Wood Karin U., Wood John M.
doaj   +1 more source

Reduction of GTP Cyclohydrolase I Feedback Regulating Protein Expression by Hydrogen Peroxide in Vascular Endothelial Cells

Journal of Pharmacological Sciences, 2005
We examined the effect of H2O2 on the expression of GTP cyclohydrolase I (GTPCH) feedback regulating protein (GFRP). Addition of H2O2 to endothelial cells decreased GFRP mRNA levels, in contrast to the increase of tetrahydrobiopterin (BH4) content and ...
Masakazu Ishii, Shunichi Shimizu, Teruaki Wajima, Tamio Hagiwara, Takaharu Negoro, Akira Miyazaki, Takashi Tobe, Yuji Kiuchi   +7 more
doaj   +1 more source

Photo‐responsive carbon dots for pyroptosis‐mediated anti‐tumor application

Responsive Materials, EarlyView.
Photo‐responsive CDs generate ROS to induce tumor cell pyroptosis, thereby stimulating antitumor immunity. Abstract Pyroptosis refers to a kind of lytic programmed cell death, characterized by the release of pro‐inflammatory cytokines during the process. Owing to its immune response stimulation ability, pyroptosis has garnered considerable attention in
Lingyun Li, Xue Wu, Zekun Yan, Jun Wu, Caishi Huang, Songnan Qu   +5 more
wiley   +1 more source

Protective Effect of Tetrahydrobiopterin Against Reactive Oxygen Species- and Nitric Oxide-induced Vascular Endothelial Cell Injury

Pteridines, 2002
Vascular endothelial cells are one of the major biological targets of reactive oxygen species (ROS) in ischemiareperfusion, diabetes, hypercholesterolemia and inflammation.
Shimizu Shunichi
doaj   +1 more source

Effect of Social Rank on Gut Microbes and Their Metabolites of Greater Long‐Tailed Hamsters (Tscherskia triton)

Integrative Zoology, EarlyView.
Social rank in greater long‐tailed hamsters (Tscherskia triton) shapes gut microbiota composition and metabolite profiles. Dominant males exhibit a “high‐vigilance, metabolically activated” phenotype, with elevated aggression and specific gut microbiota enriched in energy‐harvesting taxa and fecal queuine.
Da Zhang, Xiaoming Xu, Zhibin Zhang
wiley   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Potency (Emax) and sensitivity (pKd) of acetylcholine (ACh) cumulative concentration response curves without agent, with tetrahydrobiopterin (BH4)/L-arginin and with Tempol/Catalase in APL3W, CT3W and HCQ3W.

, 2018
Potency (Emax) and sensitivity (pKd) of acetylcholine (ACh) cumulative concentration response curves without agent, with tetrahydrobiopterin (BH4)/L-arginin and with Tempol/Catalase in APL3W, CT3W and HCQ3W.
Cristina Belizna (5937986), Caroline Poli (3155322), Marc-Antoine Begorre (5937983), Geoffrey Urbanski (5937977), Daniel Henrion (431681), Gilles Kauffenstein (436349), Laurent Loufrani (431680), Antoine Caillon (5937980)   +7 more
core   +1 more source