Results 21 to 30 of about 13,139 (196)

Effects of Tetrahydrobiopterin (BH4) on S-Nitroso-N-acetyl-D,Lpenicillamine (SNAP)-Induced HL-60 Cell Death

Pteridines, 1998
First, we examined the effects of various chemical NO-donors on the cell damage in HL-60 cells. The most potent of these was S-nitroso-N-acetyl- penicillamine (SNAP).
Kojima Shuji
doaj   +2 more sources

Tetrahydrobiopterin (BH₄) Supplementation Prevents the Cardiorenal Effects of Diabetes in Mice by Reducing Oxidative Stress, Inflammation and Fibrosis. [PDF]

Biomedicines, 2022
Background: The effects of diabetes on the cardiovascular system as well as in the kidney are profound, which include hypertrophy and fibrosis. Diabetes also induces oxidative stress, at least in part due to the uncoupling of nitric oxide synthase (NOS);
Novoa U, Soto K, Valdés C, Villaseñor J, Treuer AV, González DR.   +5 more
europepmc   +2 more sources

Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences. [PDF]

Redox Biol, 2022
Preeclampsia (PE) is a high-prevalence pregnancy disease characterized by placental insufficiency, gestational hypertension, and proteinuria. Overexpression of the A isoform of the STOX1 transcription factor (STOX1A) recapitulates PE in mice, and STOX1A overexpressing trophoblasts recapitulate PE patients hallmarks in terms of gene expression and ...
Chatre L, Ducat A, Spradley FT, Palei AC, Chéreau C, Couderc B, Thomas KC, Wilson AR, Amaral LM, Gaillard I, Méhats C, Lagoutte I, Jacques S, Miralles F, Batteux F, Granger JP, Ricchetti M, Vaiman D.   +17 more
europepmc   +5 more sources

Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties [PDF]

, 2011
Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH4) contribute to impaired vasodilation in pulmonary hypertension Due to the chemically unstable nature of BH4 it was hypothesised that oxidatively stable analogues of BR, would be able to ...
Roger M. Wadsworth, Gibson, Colin, Milliken, P. H., Wadsworth, R. M., Philip H. Milliken, Kunuthur, S. P., Suma P. Kunuthur, Colin J. Suckling, Suckling, C. J., Colin L. Gibson   +9 more
core   +4 more sources

Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina. [PDF]

J Neuroinflammation, 2017
Tetrahydrobiopterin (BH4) is an essential cofactor in multiple metabolic processes and plays an essential role in maintaining the inflammatory and neurovascular homeostasis. In this study, we have investigated the deleterious effects of BH4 deficiency on retinal vasculature during development.hph-1 mice, which display deficiency in BH4 synthesis, were ...
Rivera JC, Noueihed B, Madaan A, Lahaie I, Pan J, Belik J, Chemtob S.   +6 more
europepmc   +6 more sources

Prenatal Diagnosis of Tetrahydrobiopterin (BH4) Synthase Deficiency

Pteridines, 1991
Shintaku H., Nakajima T., Sawada Y., Hase Y., Fujioka M., Nishimura A., Isshiki G., Oura T., Hsiao Κ. J., Chen R. G.   +9 more
doaj   +2 more sources

Tetrahydrobiopterin treatment in phenylketonuria:A repurposing approach [PDF]

, 2020
In phenylketonuria (PKU) patients, early diagnosis by neonatal screening and immediate institution of a phenylalanine-restricted diet can prevent severe intellectual impairment.
Francjan J. van Spronsen, van Vliet, Danique, Evers, Roeland A F, van Spronsen, Francjan J, Roeland A. F. Evers, Danique van Vliet   +5 more
core   +1 more source

Tetrahydrobiopterin responsiveness in a series of 53 cases of phenylketonuria and hyperphenylalaninemia in Iran

Molecular Genetics and Metabolism Reports, 2015
To determine the prevalence of 6R-Tetrahydrobiopterin (BH4) responsive phenylketonuria (PKU) in 53 cases of patients with various classification of hyperphenylalaninemia and PKU Excluding the BH4 deficient type referring to children's medical center in ...
Aria Setoodeh, Bahram Yarali, Ali Rabbani, Shohreh Khatami, Sedigheh Shams   +4 more
doaj   +1 more source

Intestinal Uptake of 6(R)-L-erythro-Tetrahydrobiopterin is Distinct from the Liver-Type MTX-Sensitive Accumulation Process

Pteridines, 2005
In order to increase the tissue level of tetrahydrobiopterin (BH4 ) , supplementation with 6R-tetrahydrobiopterin (6RBH4) has been widely employed. In this work, the profile of BH4 accumulation was compared between the liver and the small intestine after
Sawabe Keiko, Suetake Yasuko, Wakasugi Kazunori Osuke, Hasegawa Hiroyuki   +3 more
doaj   +1 more source

Tetrahydrobiopterin compounds modulate intracellular signaling and reactive oxygen species levels in an in vitro model of ischemia-reperfusion injury

Pteridines, 2013
Tetrahydrobiopterin (BH4) and 4-amino-tetrahydrobiopterin (ABH4) prevent acute rejection after solid organ transplantation. Moreover, BH4 also attenuates ischemia-reperfusion injury (IRI).
Santer Peter, Ratschiller Thomas, Ashraf Muhammad Imtiaz, Werner Ernst R., Werner-Felmayer Gabriele, Maglione Manuel, Brandacher Gerald, Troppmair Jakob   +7 more
doaj   +1 more source