Results 31 to 40 of about 13,139 (196)
Antioxidants, 2022 Tetrahydrobiopterin (BH4) is an essential cofactor of all nitric oxide synthase isoforms, thus determination of BH4 levels can provide important mechanistic insight into diseases.
Ksenija Vujacic-Mirski +8 more
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Pteridines, 2003 The purpose of this study was to examine whether basic fibroblast growth factor (bFGF) stimulates tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells.
Shimizu Shunichi +4 more
doaj +1 more source
Pteridines, 2005 Tetrahydrobiopterin (BH4) was released from PC 12 cells to the extracellular fluid. We found that the BH4 outward flow from the cells placed in Hanks medium was increased when NaCl concentration of the medium was decreased.
Nakanishi Nobuo +6 more
doaj +1 more source
The effects of tetrahydrobiopterin (BH4) treatment on brain function in individuals with phenylketonuria. [PDF]
Neuroimage Clin, 2013 Phenylketonuria (PKU) is a rare genetic condition characterized by an absence or mutation of the PAH enzyme, which is necessary for the metabolism of the amino acid phenylalanine into tyrosine. Recently, sapropterin dihydrochloride, a synthetic form of tetrahydrobiopterin (BH4), has been introduced as a supplemental treatment to dietary phe control for
Christ SE, Moffitt AJ, Peck D, White DA.
europepmc +4 more sources
New evidence for assessing tetrahydrobiopterin (BH4) responsiveness
Metabolism, 2012 To evaluate the protocol we propose for detecting BH(4)-responsive patients and the possibility of delimiting more precisely the population to be tested.We recruited 102 phenylketonuric patients on a phenylalanine (Phe)-restricted diet. The initial stage of the protocol was a 24-h BH(4) loading test involving Phe loading and subsequent ingestion of the
María A, Bueno +7 more
openaire +4 more sources
Tetrahydrobiopterin Slows the Progression of Atherosclerosis
Pteridines, 2007 We investigated whether oral tetrahydrobiopterin (BH4) treatment might slow the progression of atherosclerosis using hypercholesterolemic ApoE-knockout (KO) mice.
Kunihiro Suzuki +10 more
doaj +1 more source
TREATMENT OF HYPERPHENYLALANINEMIA V WITH TETRAHYDROBIOPTERIN (BH4) AND NEUROTRANSMITTER (NT) PRECURSORS [PDF]
Pediatric Research, 1984 In a 9 month infant with the spinal fluid (CSF) NT abnormalities of biopterin synthesis defect we compared treatment with:BH4 high (20 mg/kg/d) dose only; BH4 low (3 mg/kg/d), moderate (10 mg/kg/d) or high dose with the NT precursors dopa/carbidopa (10/1 mg/kg/d) and 5-hydroxytryptophan (5 mg/kg/d); and NT precusors with phenylalanine (phe) restricted ...
Carol Greene +5 more
openaire +1 more source
Pteridines, 2006 We examined the role of endogenous tetrahydrobiopterin (BH4) on L-tyrosine-induced increase in cytosolic Ca: concentration ([Ca2+],) in the ß-cell line, HIT-T15.
Ishii Masakazu +3 more
doaj +1 more source
Regulation of melanin biosynthesis in the human epidermis by tetrahydrobiopterin.
, 1994 The participation of (6R) 5,6,7,8-tetrahydrobiopterin (6-BH4) in regulating the tyrosine supply for melanin biosynthesis was investigated by the examination of human keratinocytes, melanocytes, and epidermal suction blisters from normal human skin and ...
Gütlich, M. +8 more
core +1 more source
Pteridines, 2002 Tetrahydrobiopterin (BH4) is one of the cofactors for nitric oxide synthase (NOS), and also has a protective effect against reactive oxygen species (ROS)- and/or nitric oxide (NO)-induced cytotoxicities. Lipopolysaccharide (LPS) induces NO production and
Shiota Kazuhiro +6 more
doaj +1 more source