Results 1 to 10 of about 36,463 (268)

Delta‐9‐tetrahydrocannabinol disrupts mitochondrial function and attenuates syncytialization in human placental BeWo cells

Physiological Reports, 2020
The psychoactive component in cannabis, delta‐9‐tetrahydrocannabinol, can restrict fetal growth and development. Delta‐9‐tetrahydrocannabinol has been shown to negatively impact cellular proliferation and target organelles like the mitochondria resulting
O’Llenecia S. Walker, Rehginald Ragos, Harmeet Gurm, Mariah Lapierre, Linda L. May, Sandeep Raha   +5 more
doaj   +2 more sources

Cytotoxicity Potency of Cannabinoids Is by Serum Supplementation: Implications for In Vitro Cancer Studies [PDF]

Cancer Reports
Background Fetal calf serum (FCS) is a key supplement in cell culture, providing nutrients, and growth factors that support cancer cell proliferation.
Sanele Priscillia Mathibela, Maphuti Tebogo Lebelo, Vanessa Steenkamp   +2 more
doaj   +3 more sources

Risk Assessment of Over-the-Counter Cannabinoid-Based Cosmetics: Legal and Regulatory Issues Governing the Safety of Cannabinoid-Based Cosmetics in the UAE

Cosmetics, 2021
Purpose: The lack of scientific evidence of the safety and efficacy of over-the-counter topical cannabinoid-based cosmetics remains a concern. The current study attempted to assess the quality of cannabinoid-based cosmetic products available on the UAE ...
Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Moyad Shahwan, Baharudin Ibrahim, Mohamed Azmi Hassali, Sa’ed H. Zyoud   +5 more
doaj   +1 more source

Assessment of Orally Administered Δ9-Tetrahydrocannabinol When Coadministered With Cannabidiol on Δ9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults: A Randomized Clinical Trial

JAMA Network Open, 2023
This randomized clinical trial compares the pharmacokinetics and pharmacodynamics of orally administered Δ9-tetrahydrocannabinol (THC)-dominant and cannabidiol-dominant cannabis extracts that contained the same Δ9-THC dose in a healthy adult population ...
C. Zamarripa, Tory R. Spindle, Renuka Surujunarain, E. Weerts, Sumit Bansal, J. Unadkat, M. Paine, R. Vandrey   +7 more
semanticscholar   +1 more source

Identification of Potential Distinguishing Markers for the Use of Cannabis-Based Medicines or Street Cannabis in Serum Samples

Metabolites, 2021
Increasing prescription numbers of cannabis-based medicines raise the question of whether uptake of these medicines can be distinguished from recreational cannabis use. In this pilot study, serum cannabinoid profiles after use of cannabis-based medicines
Anne Scheunemann, Katrin Elsner, Tanja Germerott, Sergiu Groppa, Cornelius Hess, Isabelle Miederer, Alicia Poplawski, Jörg Röhrich   +7 more
doaj   +1 more source

Delta-8 tetrahydrocannabinol: A Scoping Review and Commentary.

Addiction, 2023
BACKGROUND AND AIMS Delta-8 tetrahydrocannabinol (THC) is a psychoactive substance from the Cannabis plant that has been rising in popularity in the United States since the 2018 U.S. Farm Bill implicitly legalized it.
C. LoParco, M. Rossheim, S. Walters, Z. Zhou, S. Olsson, S. Sussman   +5 more
semanticscholar   +1 more source

Anticancer activity of Δ9-tetrahydrocannabinol and cannabinol in vitro and in human lung cancer xenograft

Asian Pacific Journal of Tropical Biomedicine, 2022
Objective: To investigate the effects of Δ9-tetrahydrocannabinol, the principal psychoactive compound of Cannabis sativa, and cannabinol, a Δ9-tetrahydrocannabinol degradative product, on human non-small cell lung cancer cells.
Surang Leelawat, Kawin Leelawat, Thaniya Wannakup, Worawan Saingam, Nanthaphong Khamthong, Fameera Madaka, Athip Maha, Patamaporn Pathompak, Lukman Sueree, Thanapat Songsak   +9 more
doaj   +1 more source

Past-Year Use Prevalence of Cannabidiol, Cannabigerol, Cannabinol, and Δ8-Tetrahydrocannabinol Among US Adults

JAMA Network Open, 2023
This survey study characterizes past-year use prevalence and factors associated with use of cannabidiol, cannabigerol, cannabinol, and Δ8-tetrahydrocannabinol among US adults.
Adrianne R. Wilson-Poe, Tristin Smith, Michael R. Elliott, D. Kruger, K. Boehnke   +4 more
semanticscholar   +1 more source

Cannabis Legalization and Detection of Tetrahydrocannabinol in Injured Drivers.

New England Journal of Medicine, 2022
BACKGROUND The effect of cannabis legalization in Canada (in October 2018) on the prevalence of injured drivers testing positive for tetrahydrocannabinol (THC) is unclear.
J. Brubacher, H. Chan, S. Erdelyi, J. A. Staples, M. Asbridge, R. Mann   +5 more
semanticscholar   +1 more source

Differences in Inhibitory Control and Resting Brain Metabolism between Older Chronic Users of Tetrahydrocannabinol (THC) or Cannabidiol (CBD)—A Pilot Study

Brain Sciences, 2022
Δ9-Tetrahydrocannabinol is the main psychoactive component of cannabis and cannabidiol is purportedly responsible for many of the medicinal benefits. The effects of Δ9-tetrahydrocannabinol and cannabidiol in younger populations have been well studied ...
Thorsten Rudroff, Craig D. Workman, Phillip E. Gander, Justin R. Deters, Laura L. Boles Ponto   +4 more
doaj   +1 more source