Results 21 to 30 of about 48,054 (298)

Population pharmacokinetic modelling revealed large variability in oromucosal absorption of Δ⁹-tetrahydrocannabinol in older patients with poor appetite. [PDF]

Br J Clin Pharmacol
Aim Cannabis‐based medicines are gaining interest and being explored for new therapeutic indications, many of which commonly affect older medical patients. As most previous studies of the population pharmacokinetics of cannabinoids have been performed in healthy adults, this study aimed to investigate the population pharmacokinetics of Δ9 ...
Storgaard IK, Nielsen RL, Houlind MB, Bornæs O, Christensen LWS, Andersen AL, Juul-Larsen HG, Jørgensen LM, Breindahl T, Jawad BN, Altintas I, Andersen O, Lund TM.   +12 more
europepmc   +2 more sources

Prevalence of psychoactive substances in Dutch and Belgian traffic [PDF]

, 2012
Objective: The purpose of this study was to compare the prevalence of psychoactive substances in general traffic in The Netherlands and Belgium. Method: Randomly selected car drivers and drivers of small vans in six police regions in The Netherlands and ...
Brookhuis, Karel, Hagenzieker, Marjan, Houwing, Sjoerd, Legrand, Sara-Ann, Mathijssen, René, Verstraete, Alain   +5 more
core   +2 more sources

Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation [PDF]

, 2011
The herb Cannabis sativa (C. sativa) has been used in China and on the Indian subcontinent for thousands of years as a medicine. However, since it was brought to the UK and then the rest of the western world in the late 19th century, its use has been a ...
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core   +3 more sources

The phytocannabinoid, Δ(9) -tetrahydrocannabivarin, can act through 5-HT1 A receptors to produce antipsychotic effects [PDF]

, 2015
Funded by: •GW Pharmaceuticals Acknowledgements: The authors wish to thank Mrs Lesley Stevenson for technical support and Dr John Raymond, Dr Keith Parker and Dr Ethan Russo for providing human 5-HT1A CHO cells.
Cascio, Maria Grazia, Marini, Pietro, Parolaro, Daniela, Pertwee, Roger G., Zamberletti, Erica   +4 more
core   +1 more source

Cannabinoid signalling in TNF-alpha induced IL-8 release [PDF]

, 2006
Original article can be found at: http://www.sciencedirect.com/science/journal/00142999 Copyright Elsevier B.V.
Baydoun, A. R., Molleman, A., Mormina, M. E., Thakur, S., Whelan, C.J.   +4 more
core   +1 more source

The therapeutic aspects of the endocannabinoid system (ECS) for cancer and their development: from nature to laboratory [PDF]

, 2016
The endocannabinoid system (ECS) is a group of neuromodulatory lipids and their receptors, which are widely distributed in mammalian tissues. ECS regulates various cardiovascular, nervous, and immune system functions inside cells.
Botta, Bruno, Czarnecka, Anna M., Khan, Mohammed I., Król, Magdalena, Sobocińska, Anna A., Szczylik, Cezary   +5 more
core   +1 more source

Hippocampal differential expression underlying the neuroprotective effect of delta-9-tetrahydrocannabinol microdose on old mice

Frontiers in Neuroscience, 2023
Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound of the cannabis plant and an exogenous ligand of the endocannabinoid system. In previous studies, we demonstrated that a single microdose of THC (0.002 mg/kg, 3–4 orders of magnitude
Guy Shapira, Guy Shapira, Ifat Israel-Elgali, Ifat Israel-Elgali, Meitar Grad, Eden Avnat, Lital Rachmany, Yosef Sarne, Noam Shomron, Noam Shomron, Noam Shomron   +10 more
doaj   +1 more source

Involvement of Adenosine A₂A Receptors in Anxiety-Like Behaviors in Tetrahydrocannabinol-Treated Mice. [PDF]

Brain Behav
This study evaluated anxiety‐like behavior in mice across treatment and control groups using open field and elevated plus maze tests, followed by hippocampal receptor gene expression analysis. The combined behavioral and molecular data identify potential receptor‐level mechanisms underlying the observed treatment‐associated behavioral changes. ABSTRACT
Ün B, Akarsakarya Z, Özü ÖY, Ilgaz NS, Yılmaz MB, Seçilmiş D, Seçilmiş MA.   +6 more
europepmc   +2 more sources

Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation [PDF]

, 2016
Since the discovery of the endocannabinoid system consisting of cannabinoid receptors, endogenous ligands, and biosynthetic and metabolizing enzymes, interest has been renewed in investigating the promise of cannabinoids as therapeutic agents.
McCoy, Kathleen L.
core   +4 more sources

Effects of Δ⁹-tetrahydrocannabinol (THC) vapor inhalation in Sprague-Dawley and Wistar rats. [PDF]

, 2021
An inhalation system based on e-cigarette technology produces hypothermic and antinociceptive effects of Δ⁹-tetrahydrocannabinol (THC) in rats. Indirect comparison of some prior investigations suggested differential impact of inhaled THC between Wistar ...
Cole, Maury, Creehan, Kevin M, Kerr, Tony M, Taffe, Michael A, Vandewater, Sophia A   +4 more
core   +1 more source