Results 21 to 30 of about 36,463 (268)

In the Swim of Cannabis: Developmental Toxicity and Metabolomic Pathway Alterations of Zebrafish Larvae Exposed to THC for the Assessment of Its Potential Environmental and Human Health Impact

Molecules, 2022
As the pharmacological properties and therapeutic applications of Cannabis sativa L. pace with the upsurge of interest of the scientific community in harnessing its constituent phytocannabinoids, illicit use may raise serious health issues ...
Theodoros Chatzimitakos, Ieremias Chousidis, Dimitrios Leonardos, Constantine Stalikas, Ioannis Leonardos   +4 more
doaj   +1 more source

Sex Differences in Tolerance to Delta-9-Tetrahydrocannabinol in Mice With Cisplatin-Evoked Chronic Neuropathic Pain

Frontiers in Molecular Biosciences, 2021
Tolerance to the pain-relieving effects of cannabinoids limits the therapeutic potential of these drugs in patients with chronic pain. Recent preclinical research with rodents and clinical studies in humans has suggested important differences between ...
Angela N. Henderson-Redmond, Angela N. Henderson-Redmond, Angela N. Henderson-Redmond, LaTaijah C. Crawford, LaTaijah C. Crawford, Diana E. Sepulveda, Diana E. Sepulveda, David E. Hale, Julia J. Lesperance, Daniel J. Morgan, Daniel J. Morgan, Daniel J. Morgan, Daniel J. Morgan   +12 more
doaj   +1 more source

Oral Administration of Cannabis and Δ-9-tetrahydrocannabinol (THC) Preparations: A Systematic Review

Medicina, 2020
Background and objective: Changes in cannabis legalization regimes in several countries have influenced the diversification of cannabis use. There is an ever-increasing number of cannabis forms available, which are gaining popularity for both ...
Lourdes Poyatos, A. P. Pérez-Acevedo, E. Papaseit, C. Pérez-Mañá, S. Martín, O. Hladun, Adrià Siles, M. Torrens, F. Busardò, M. Farré   +9 more
semanticscholar   +1 more source

Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Emotion, Cognition, and Attention: A Double-Blind, Placebo-Controlled, Randomized Experimental Trial in Healthy Volunteers

Frontiers in Psychiatry, 2020
The two main phytocannabinoids—delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD)—have been extensively studied, and it has been shown that THC can induce transient psychosis. At the same time, CBD appears to have no psychotomimetic potential.
Timo Woelfl, Cathrin Rohleder, Cathrin Rohleder, Juliane K. Mueller, Juliane K. Mueller, Bettina Lange, Anne Reuter, Anna Maria Schmidt, Dagmar Koethe, Dagmar Koethe, Martin Hellmich, F. Markus Leweke, F. Markus Leweke   +12 more
doaj   +1 more source

EVALI Vaping Liquids Part 1: GC-MS Cannabinoids Profiles and Identification of Unnatural THC Isomers

Frontiers in Chemistry, 2021
Tetrahydrocannabinol (THC)-containing products played a major role in the 2019 US nationwide outbreak of pulmonary lung illness associated with e-cigarettes or vaping liquids (EVALI).
Laura A. Ciolino, Tracy L. Ranieri, Jana L. Brueggemeyer, Allison M. Taylor, Angela S. Mohrhaus   +4 more
doaj   +1 more source

How does cannabidiol (CBD) influence the acute effects of delta-9-tetrahydrocannabinol (THC) in humans? A systematic review.

Neuroscience and Biobehavioral Reviews, 2019
The recent liberalisation of cannabis regulation has increased public and scientific debate about its potential benefits and risks. A key focus has been the extent to which cannabidiol (CBD) might influence the acute effects of delta-9 ...
A. Freeman, K. Petrilli, R. Lees, C. Hindocha, C. Mokrysz, H. V. Curran, R. Saunders, Tom P. Freeman   +7 more
semanticscholar   +1 more source

Delta-9-Tetrahydrocannabinol and Cannabidiol Drug-Drug Interactions

Medical Cannabis and Cannabinoids, 2020
Although prescribing information (PI) is often the initial source of information when identifying potential drug-drug interactions, it may only provide a limited number of exemplars or only reference a class of medications without providing any specific ...
Paul T. Kocis, K. Vrana
semanticscholar   +1 more source

E‐cigarette or Vaping Product Use–Associated Lung Injury Produced in an Animal Model From Electronic Cigarette Vapor Exposure Without Tetrahydrocannabinol or Vitamin E Oil

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2020
E‐cigarette or vaping product use–associated lung injury was recognized in the United States in the summer of 2019 and is typified by acute respiratory distress, shortness of breath, chest pain, cough, and fever, associated with vaping. It can mimic many
M. Kleinman, R. Arechavala, D. Herman, Jianru Shi, Irene Hasen, Amanda Ting, W. Dai, Juan E. Carreño, Jesus Chavez, Lifu Zhao, R. Kloner   +10 more
semanticscholar   +1 more source

Tetrahydrocannabinols

Cancer and Metastasis Reviews, 2023
Tetrahydrocannabinols (THCs) antagonize the CB1 and CB2 cannabinoid receptors, whose signaling to the endocannabinoid system is essential for controlling cell survival and proliferation as well as psychoactive effects. Most tumor cells express a much higher level of CB1 and CB2; THCs have been investigated as potential cancer therapeutic due to their ...
Prateeksha, Prateeksha, Sharma, Vivek K., Singh, Shiv M., Sharma, Minaxi, Diwan, Deepti, Hesham, Abd El Latif, Guleria, Sanjay, Nguyen, Quang D., Gupta, Vijai K., Singh, Brahma N.   +9 more
openaire   +1 more source

Hippocampal differential expression underlying the neuroprotective effect of delta-9-tetrahydrocannabinol microdose on old mice

Frontiers in Neuroscience, 2023
Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound of the cannabis plant and an exogenous ligand of the endocannabinoid system. In previous studies, we demonstrated that a single microdose of THC (0.002 mg/kg, 3–4 orders of magnitude
Guy Shapira, Guy Shapira, Ifat Israel-Elgali, Ifat Israel-Elgali, Meitar Grad, Eden Avnat, Lital Rachmany, Yosef Sarne, Noam Shomron, Noam Shomron, Noam Shomron   +10 more
doaj   +1 more source