Results 31 to 40 of about 48,054 (298)

Effect of harvest time on the compositional changes in essential oils, cannabinoids, and waxes of hemp (Cannabis sativa L.)

open access: yesRoyal Society Open Science, 2022
Demand for cannabinoid is growing, with the global market expected to reach $9.69 billion by 2025. Understanding how chemical composition changes in hemp at different harvest times is crucial to maximizing this industrial crop value.
Pakin Noppawan   +6 more
doaj   +1 more source

Tetrahydrocannabinols

open access: yesCancer and Metastasis Reviews, 2023
Tetrahydrocannabinols (THCs) antagonize the CB1 and CB2 cannabinoid receptors, whose signaling to the endocannabinoid system is essential for controlling cell survival and proliferation as well as psychoactive effects. Most tumor cells express a much higher level of CB1 and CB2; THCs have been investigated as potential cancer therapeutic due to their ...
Prateeksha, Prateeksha   +9 more
openaire   +1 more source

Harnessing autophagy to overcome mitogen‐activated protein kinase kinase inhibitor‐induced resistance in metastatic melanoma [PDF]

open access: yes, 2019
Background Patients with malignant melanoma often relapse after treatment with BRAF and/or mitogen‐activated protein kinase kinase (MEK) inhibitors (MEKi) owing to development of drug resistance.
Alexander, M.   +6 more
core   +1 more source

Assessment of clinical outcomes in patients with fibromyalgia: Analysis from the UK Medical Cannabis Registry

open access: yesBrain and Behavior, 2023
Introduction : There are limited therapeutic options for individuals with fibromyalgia. The aim of this study is to analyze changes in health‐related quality of life and incidence of adverse events of those prescribed cannabis‐based medicinal products ...
Claire Wang   +10 more
doaj   +1 more source

Pharmacokinetics of Cannabidiol Following Intranasal, Intrarectal, and Oral Administration in Healthy Dogs

open access: yesFrontiers in Veterinary Science, 2022
The therapeutic potential of cannabidiol (CBD), a non-psychtropic component of the Cannabis sativa plant, is substantiated more and more. We aimed to determine the pharmacokinetic behavior of CBD after a single dose via intranasal (IN) and intrarectal ...
Dakir Polidoro   +11 more
doaj   +1 more source

IgE-Mediated Hypersensitivity Reactions to Cannabis in Laboratory Personnel [PDF]

open access: yes, 2011
Background: There have been sporadic reports of hypersensitivity reactions to plants of the Cannabinaceae family (hemp and hops), but it has remained unclear whether these reactions are immunologic or nonimmunologic in nature.
Anibarro B   +17 more
core   +1 more source

In planta Female Flower Agroinfiltration Alters the Cannabinoid Composition in Industrial Hemp (Cannabis sativa L.)

open access: yesFrontiers in Plant Science, 2022
Industrial hemp is a diploid (2n = 20), dioecious plant, and an essential source of various phytochemical productions. More than 540 phytochemicals have been described, some of which proved helpful in the remedial treatment of human diseases.
Michihito Deguchi   +5 more
doaj   +1 more source

Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study [PDF]

open access: yes, 2008
<b>Objective</b>: To compare the analgesic efficacy and side effects of the synthetic cannabinoid nabilone with those of the weak opioid dihydrocodeine for chronic neuropathic pain.
Frank, B.   +4 more
core   +2 more sources

Cannabinoids and Multiple Sclerosis: A Critical Analysis of Therapeutic Potentials and Safety Concerns

open access: yesPharmaceutics, 2023
Multiple sclerosis (MS) is a complicated condition in which the immune system attacks myelinated axons in the central nervous system (CNS), destroying both myelin and axons to varying degrees.
Roua A. Nouh   +2 more
doaj   +1 more source

The tetrahydrocannabinol and tetrahydrocannabinolic acid content of cannabis products

open access: yesJournal of Pharmacy and Pharmacology, 1981
Abstract Cannabinoid acids readily decarboxylate to the corresponding cannabinoid. Methods are available for the determination of Δ9-tetrahydrocannabinol (THC) and its acids (THCA) and published data on the levels of these compounds in cannabis are summarized.
P B, Baker, B J, Taylor, T A, Gough
openaire   +2 more sources

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