Iridium-catalysed ortho-H/D and -H/T exchange under basic conditions : C-H activation of unprotected tetrazoles [PDF]
, 2016 The first examples of selective ortho-directed C-H activation with unprotected 2-aryltetrazoles are described. A new base-assisted protocol for iridium (I) hydrogen isotope exchange catalysis allows access to ortho-deuterated and tritiated tetrazoles ...
Atzrodt, Jens +6 more
core +1 more source
Long-range 1H-15N J couplings providing a method for direct studies of the structure and azide-tetrazole equilibrium in a series of azido-1,2,4-triazines and azidopyrimidines [PDF]
, 2013 The selectively 15N labeled azido-1,2,4-triazine 2*A and azidopyrimidine 4*A were synthesized by treating hydrazinoazines with 15N-labeled nitrous acid.
Arseniev, A. S. +6 more
core +1 more source
Solar Flow Synthesis of Polymer Nanoparticles: Scaling Local Experiments to Global Potential
Angewandte Chemie, EarlyView.The large‐scale sunlight‐induced photochemical synthesis of polymer nanoparticles based on the Diels–Alder step‐growth polymerization of a bismaleimide and a difunctional o‐methylbenzaldehyde in a self‐built solar flow reactor is introduced. Furthermore, a framework is established to translate sunlight‐driven experimental results globally—validated in ...
Jochen A. Kammerer +7 more
wiley +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 A series of 1-aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as microtubule destabilizers were designed, synthesised and evaluated for anticancer activity.
Chao Wang +11 more
doaj +1 more source
Photochemical Transformations of Tetrazole Derivatives: Applications in Organic Synthesis [PDF]
, 2010 Tetrazoles remain a challenge to photochemists. Photolysis leads to cleavage of the tetrazolyl ring, may involve various photodegradation pathways and may produce a diversity of photoproducts, depending on the structure and conformational flexibility of
Amin Ismael +18 more
core +2 more sources
Synthesis, single crystal analysis, biological and docking evaluation of tetrazole derivatives
Heliyon, 2018 Tetrazoles are conjugated nitrogen-rich heterocycles considered as bio-isosteres of carboxylic acids. Tetrazoles owing to their conjugated structures serve as biologically relevant potent scaffolds.
Hamid Aziz +4 more
doaj +1 more source
Molecules, 2020 A series of novel 7-substituted-5-(1H-indol-3-yl)tetrazolo[1,5-a]pyrimidine-6-carbonitrile was synthesized via a one-pot, three-multicomponent reaction of appropriate aldehydes, 1H-tetrazole-5-amine and 3-cyanoacetyl indole in catalytic triethylamine ...
Mohamed A. A. Radwan +2 more
doaj +1 more source
Synthesis of tetrazole analogs of amino acids using Fmoc chemistry: isolation of amino free tetrazoles and their incorporation into peptides [PDF]
, 2007 An efficient synthesis of tetrazole analogs of amino acids starting from Nα-Fmoc amino acid (Fmoc = 9-fluorenylmethoxycarbonyl) in a three-step protocol is reported.
Chennakrishnareddy, G. +3 more
core +2 more sources
Synthesis of selected 5-thio-substituted tetrazole derivatives and evaluation of their antibacterial and antifungal activities [PDF]
Journal of the Serbian Chemical Society, 2011 Several 5-thio-substituted tetrazole derivatives were efficiently synthesized by a three-step process. The substituted tetrazol-5-thiol, namely, 1-benzyl-1H-tetrazole-5-thiol (2) was prepared by refluxing commercially available benzyl isothiocyanate (1 ...
NALILU SUCHETHA KUMARI +7 more
doaj
Indium-Mediated Cleavage of the Trityl Group from Protected 1H-Tetrazoles [PDF]
, 2015 On treatment with indium metal in MeOH–THF, trityl groups undergo reductive removal from 1H-protected tetrazoles (including aliphatic, aromatic, and heteroaromatic substituents), affording the corresponding free tetrazoles in excellent yields, without ...
Behloul, Cherif +5 more
core +2 more sources