Results 51 to 60 of about 25,716 (303)

Unusual behavior in the reactivity of 5-substituted-1H-tetrazoles in a resistively heated microreactor

Beilstein Journal of Organic Chemistry, 2011
The decomposition of 5-benzhydryl-1H-tetrazole in an N-methyl-2-pyrrolidone/acetic acid/water mixture was investigated under a variety of high-temperature reaction conditions.
Bernhard Gutmann, Toma N. Glasnov, Tahseen Razzaq, Walter Goessler, Dominique M. Roberge, C. Oliver Kappe   +5 more
doaj   +1 more source

Synthesis of 1,5-Disubstituted Tetrazoles in Aqueous Micelles at Room Temperature

Molbank, 2021
The ongoing study is a Ugi-azide four-component reaction for the synthesis of 1,5-disubstituted tetrazole(1,5-DST), which involves an aldehyde, different amines, isocyanides, and as azide’s source the Trimethylsilylazide (TMSN3), in water as solvent ...
Mohammed Abdessalam, Madjid Ait Sidhoum, Fatima-Zohra Zradni, Hocine Ilikti   +3 more
doaj   +1 more source

Innovative synthesis of drug-like molecules using tetrazole as core building blocks

Beilstein Journal of Organic Chemistry
Tetrazole is widely utilized as a bioisostere for carboxylic acid in the field of medicinal chemistry and drug development, enhancing the drug-like characteristics of various molecules.
Jingyao Li, Ajay L. Chandgude, Qiang Zheng, Alexander Dömling   +3 more
doaj   +1 more source

Tetrazole Is a Novel Zinc Binder Chemotype for Carbonic Anhydrase Inhibition. [PDF]

ACS Med Chem Lett
Giovannuzzi S, Angeli A, Begines P, Ferraroni M, Nocentini A, Supuran CT.   +5 more
europepmc   +3 more sources

Ungesättigte Phosphor‐Elektrophile zur Untersuchung von Protein‐Tyrosin‐Phosphatasen

Angewandte Chemie, EarlyView.
Negativ geladene Aryl‐Ethynyl‐Phosphonamid‐ und Phosphonsäuren werden als reaktionsarme Elektrophile für peptidbasierte Aktivitätssonden eingeführt, die eine selektive, zielspezifische Profilierung von Protein‐Tyrosin‐Phosphatasen ermöglichen. Die Sonden zeigen keine Off‐Target‐Cystein‐Reaktivität und binden in der globalen Proteomanalyse nur an die ...
Eleftheria Poulou, Max Ruwolt, Christian E. Stieger, Kristin Kemnitz‐Hassanin, Christian P. R. Hackenberger   +4 more
wiley   +1 more source

Copper-decorated core–shell structured ordered mesoporous containing cobalt ferrite nanoparticles as high-performance heterogeneous catalyst toward synthesis of tetrazole

Scientific Reports, 2023
The present work describes the synthesis of copper immobilization on CoFe2O4/MCM-41 as a catalyst, which is created by attaching copper and ligand (N-phenyl anthranilic acid (PA)) on the surface of CoFe2O4/MCM-41 (CoFe2O4/MCM-41/PA/Cu).
Somayeh Molaei, Mohammad Ghadermazi
doaj   +1 more source

A versatile and an efficient synthesis of 5-​substituted-​1H-​tetrazoles [PDF]

, 2011
A simple, efficient and a versatile method for the synthesis of 5-​substituted-​1H-​tetrazoles by a [3+2]​-​cycloaddn. reaction of aryl nitriles with sodium azide in DMF using ZrOCl2·8 H2O as catalyst has been developed. The reactions work well at 100°C
Gowd Madhusudana Reddy Muthukur Bhoje, ., Pasha Mohamed Afzal, .   +1 more
core   +1 more source

Electrostatic Activation of Tetrazoles [PDF]

The Journal of Organic Chemistry, 2020
Photoactivation of tetrazoles to form nitrile imines primed for 1,3-dipolar cycloaddition reactions is of widespread utility in chemistry. In contrast, the corresponding thermal reactions usually possess prohibitively high barriers and have garnered significantly less attention.
Vincent Doan, Benjamin B. Noble, Michelle L. Coote   +2 more
openaire   +3 more sources

Discovery of tetrazole thioethers: An efficient, environmentally friendly and metal-free S-arylation using diaryliodonium salts

Journal of Saudi Chemical Society
An efficient, environmentally friendly, and metal-free method for the synthesis of functionalized tetrazole thioethers via the S-arylation of tetrazole-5-thiones using diaryliodonium salts as aryl transfer reagents has been developed.
Xiaogang Li, Xuesong Wang, Yan Wang, Yinfeng Tan, Dong Liu, Xueying Zhang, Youbin Li, Junyu Xu   +7 more
doaj   +1 more source

Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases

Angewandte Chemie International Edition, EarlyView.
Charged aryl‐ethynyl phosphonamidic and phosphonic acids are introduced as low‐reactivity electrophiles for peptide‐based activity probes that enable selective, target‐specific profiling of protein tyrosine phosphatases. The probes show no off‐target cysteine reactivity and engage only the interacting phosphatase in global proteomic analysis.
Eleftheria Poulou, Max Ruwolt, Christian E. Stieger, Kristin Kemnitz‐Hassanin, Christian P. R. Hackenberger   +4 more
wiley   +1 more source