Results 1 to 10 of about 13,481 (259)

Photochemical Transformations of Tetrazole Derivatives: Applications in Organic Synthesis [PDF]

Molecules, 2010
Tetrazoles remain a challenge to photochemists. Photolysis leads to cleavage of the tetrazolyl ring, may involve various photodegradation pathways and may produce a diversity of photoproducts, depending on the structure and conformational flexibility of ...
Luís Miguel Teodoro Frija, Amin Ismael, Maria Lurdes Santos Cristiano   +2 more
doaj   +3 more sources

Ambident reactivity of enolizable 5-mercapto-1H-tetrazoles in trapping reactions with in situ-generated thiocarbonyl S-methanides derived from sterically crowded cycloaliphatic thioketones [PDF]

Beilstein Journal of Organic Chemistry
The in situ-generated thiocarbonyl S-methanides (thiocarbonyl ylides), derived from cycloaliphatic thioketones, are efficiently trapped by enolizable 1-substitued 5-mercapto-1H-tetrazoles and formation of the corresponding N–H or S–H insertion products ...
Grzegorz Mlostoń, Małgorzata Celeda, Marcin Palusiak, Heinz Heimgartner, Marta Denel-Bobrowska, Agnieszka B. Olejniczak   +5 more
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Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids [PDF]

Frontiers in Pharmacology
The triazole antifungals posaconazole and itraconazole can cause pseudohyperaldosteronism with hypertension and hypokalemia, edema, and gynecomastia by inhibiting steroid synthesis and metabolism.
Marie-Christin Jäger, Marie-Christin Jäger, Víctor González-Ruiz, Víctor González-Ruiz, Friedrich L. Joos, Friedrich L. Joos, Denise V. Winter, Julien Boccard, Julien Boccard, Thorsten Degenhardt, Steve Brand, Serge Rudaz, Serge Rudaz, George R. Thompson, Alex Odermatt, Alex Odermatt   +15 more
doaj   +2 more sources

Exploring tetrazole chemistry: synthetic techniques, structure–activity relationship, and pharmacological insights in antimicrobial and anticancer therapy [PDF]

Frontiers in Chemistry
Tetrazoles are nitrogen-rich heterocycles that have attracted interest because of their numerous applications in pharmaceutical and medicinal chemistry.
Lalmohan Maji, Ghanshyam Teli, Ghanshyam Teli, Rohit Pal, Neelesh Maheshwari, Praveen Kumar Soni, Gurubasavaraja Swamy Purawarga Matada, Mahendra Singh Rathore, Venkatesan Saravanan, Kathiravan Muthukumaradoss   +9 more
doaj   +2 more sources

A novel Pd complex coated on TiFe2O4 magnetic nanoparticles as an efficient and recoverable catalyst for the synthesis of 5-substituted 1H-tetrazoles [PDF]

Scientific Reports
This study presents the synthesis of magnetic nanoparticles using commercially available precursors, including FeCl2·4H2O and C12H28O4Ti. The nanoparticles were coated with a silica layer and subsequently functionalized with 3-chloropropyltriethoxysilane
Abdulrahman A. Almehizia, Munthar Kadhim Abosaoda, Anjan Kumar, Vicky Jain, Suhas Ballal, Abhayveer Singh, Karthikeyan Jayabalan, Subhashree Ray, Pranchal Rajput, Ojas Prakashbhai Doshi   +9 more
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Substituent Effects on EI-MS Fragmentation Patterns of 5-Allyloxy-1-aryl-tetrazoles and 4-Allyl-1-aryl-tetrazole-5-ones; Correlation with UV-Induced Fragmentation Channels

Molecules, 2021
1,4- and 1,5-disubstituted tetrazoles possess enriched structures and versatile chemistry, representing a challenge for chemists. In the present work, we unravel the fragmentation patterns of a chemically diverse range of 5-allyloxy-1-aryl-tetrazoles and
Alina Secrieru, Rabah Oumeddour, Maria L. S. Cristiano   +2 more
doaj   +1 more source

Data on synthesis and structure–activity relationships of tetrazolato-bridged dinuclear platinum(II) complexes

Data in Brief, 2022
In this data file, the synthetic procedures for the preparation of a series of anticancer tetrazolato-bridged dinuclear platinum(II) complexes ([{cis-Pt(NH3)2}2(μ-OH)(μ-5-R-tetrazolato-N2,N3)]n+ (n = 1 or 2, tetrazolato-bridged complexes)) and of the ...
Seiji Komeda, Hiroki Yoneyama, Masako Uemura, Takahiro Tsuchiya, Miyuu Hoshiyama, Tomoya Sakazaki, Keiichi Hiramoto, Shinya Harusawa   +7 more
doaj   +1 more source

Photochemistry of 1-Phenyl-4-Allyl-Tetrazol-5-One: A Theoretical Study Contribution towards Mechanism Elucidation

Applied Sciences, 2021
The photodegradation mechanism of 1-phenyl-4-allyl-tetrazol-5-one has been studied using (time-dependent) density functional theory with the M06-HF, B3LYP, and PBE0 functionals and the VDZ basis set.
Amilcar Duque-Prata, Carlos Serpa, Pedro J. S. B. Caridade   +2 more
doaj   +1 more source

‘Atypical Ugi’ tetrazoles

Chemical Communications, 2020
We surprisingly found that combining the substrates of Ugi tetrazole reaction gives two different constitutional isomeric Ugi products A and B. A is the expected classical Ugi products whereas B is an isomeric product (‘atypical Ugi’).
Eman M. M. Abdelraheem, Imogen Goodwin, Shabnam Shaabani, Michel P. de Haan, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuścik, Alexander Dömling   +6 more
openaire   +5 more sources

Generation of Sulfonylated Tetrazoles through an Iron-Catalyzed Multicomponent Reaction Involving Sulfur Dioxide

iScience, 2020
Summary: As a privileged motif, tetrazoles can be widely found in pharmaceuticals and materials science. Herein, a five-component reaction of cycloketone oxime esters, alkynes, DABCO·(SO2)2, and two molecules of trimethylsilyl azide under iron catalysis ...
Jun Zhang, Xuefeng Wang, Yunyan Kuang, Jie Wu   +3 more
doaj   +1 more source