Results 11 to 20 of about 18,166 (271)
Tetrazoles via Multicomponent Reactions [PDF]
Chemical Reviews, 2019 Tetrazole derivatives are a prime class of heterocycles, very important to medicinal chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide moieties but also to their metabolic stability and other beneficial ...
Constantinos G. Neochoritis +2 more
semanticscholar +5 more sources
Chemical Communications, 2020 We surprisingly found that combining the substrates of Ugi tetrazole reaction gives two different constitutional isomeric Ugi products A and B. A is the expected classical Ugi products whereas B is an isomeric product (‘atypical Ugi’).
Eman M. M. Abdel-Raheem +7 more
openaire +6 more sources
Synthesis of new bile acid-fused tetrazoles using the Schmidt reaction
Beilstein Journal of Organic Chemistry, 2021 A practical and high-yielding Schmidt reaction for the synthesis of fused tetrazoles from bile acid precursors was developed. Mild reaction conditions using TMSN3 instead of hydrazoic acid as an azide source produced good yields of the desired tetrazoles.
Dušan Đ. Škorić +4 more
doaj +1 more source
Synthesis of α-Sulfoximino Tetrazoles via Azido-Ugi Four-Component Reaction
SynOpen, 2022 The sulfoximine-based tetrazoles have been synthesized via azido-Ugi four-component reactions of sulfoximines, isocyanides, aldehydes, and TMS-azide in MeOH at 70 °C in the presence of InCl3.
C. P. Irfana Jesin +2 more
doaj +1 more source
Multi-Gram Synthesis of Enantiopure 1,5-Disubstituted Tetrazoles Via Ugi-Azide 3-Component Reaction
Molecules, 2018 Tetrazoles have been widely studied for their biological properties. An efficient route for large-scale synthesis of 1,5-disubstituted tetrazoles (1,5-DTs) is presented.
Pietro Capurro +4 more
doaj +1 more source
Pharmaceuticals, 2022 Herein, the synthesis and anticancer activity evaluation of a series of novel β-carbolines is reported. The reactivity of nitrosoalkenes towards indole was explored for the synthesis of novel tryptophan analogs where the carboxylic acid was replaced by a
João L. P. Ribeiro +4 more
doaj +1 more source
Electrostatic Activation of Tetrazoles [PDF]
The Journal of Organic Chemistry, 2020 Photoactivation of tetrazoles to form nitrile imines primed for 1,3-dipolar cycloaddition reactions is of widespread utility in chemistry. In contrast, the corresponding thermal reactions usually possess prohibitively high barriers and have garnered significantly less attention.
Vincent Doan +2 more
openaire +4 more sources
Refinement of Copper(II) Azide with 1‐Alkyl‐5H‐tetrazoles: Adaptable Energetic Complexes
Angewandte Chemie, 2020 A concept for stabilizing highly sensitive and explosive copper(II) azide with 1‐N‐substituted tetrazoles is described. It was possible to stabilize the system by the use of highly endothermic, nitrogen‐rich ligands.
Maximilian H. H. Wurzenberger +4 more
semanticscholar +1 more source
6-(Tetrazol-5-yl)-7-aminoazolo[1,5-a]pyrimidines as Novel Potent CK2 Inhibitors
Molecules, 2022 In this work, we describe the design, synthesis, and structure-activity relationship of 6-(tetrazol-5-yl)-7-aminoazolo[1,5-a]pyrimidines as inhibitors of Casein kinase 2 (CK2).
Grigoriy V. Urakov +6 more
doaj +1 more source
Acta Chimica Slovenica, 2020 A new, efficient and convenient method for the synthesis of 5-substituted 1H-tetrazole derivatives with a wide range of substituents in good to excellent yields has been developed.
Reza Khalifeh +2 more
doaj +1 more source