Results 41 to 50 of about 13,481 (259)
Novel Therapeutic Approaches to Invasive Candidiasis: Considerations for the Clinician
Infection and Drug Resistance, 2023 Frederic Lamoth1,2 1Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; 2Institute of Microbiology, Department of Laboratory Medicine and Pathology, Lausanne University ...
Lamoth F
doaj
Kinetics and mechanism of organocatalytic aza-Michael additions: direct observation of enamine intermediates. [PDF]
, 2012 The imidazoles 1a–g add to the CC-double bond of the iminium ion 2 with rate constants as predicted by the equation log k = sN(N + E). Unfavourable proton shifts from the imidazolium unit to the enamine fragment in the adduct 3 account for the failure of
Ahrendt +33 more
core +1 more source
Acta Chimica Slovenica, 2020 A new, efficient and convenient method for the synthesis of 5-substituted 1H-tetrazole derivatives with a wide range of substituents in good to excellent yields has been developed.
Reza Khalifeh +2 more
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Design, synthesis, in silico toxicity prediction, molecular docking, and evaluation of novel pyrazole derivatives as potential antiproliferative agents [PDF]
, 2016 A new series of pyrazole derivatives were designed by docking into vascular endothelial growth factor receptor-2 (VEGFR-2) kinase active site. The designed compounds were synthesized and evaluated for in vitro antiproliferative activity against HT-29 ...
Chandra, Narendra Sharath JN +4 more
core +1 more source
Green Chemistry Letters and Reviews, 2018 Microwave assisted synthesis of 1-substituted-1H-tetrazoles was developed using zinc sulfide nanoparticles as heterogeneous catalyst under solvent free conditions.
Hossein Naeimi +2 more
doaj +1 more source
Scientific Reports, 2023 An efficient synthesis of 5-substituted 1H-tetrazoles was successfully achieved through one-pot multi-component condensation reactions of some aromatic aldehydes or indolin-2,3-dione with malononitrile and sodium azide using diverse reaction conditions ...
Ahmed El-Sewedy +4 more
doaj +1 more source
Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.Diazirines are three‐membered, nitrogen‐containing heterocycles that decompose under light or heat to generate carbenes. For the past two decades, they have served mainly as minimally invasive tags in photoaffinity labeling (PAL). More recently, their value as versatile carbene precursors has been recognized.
Dominik Schnalzer +4 more
wiley +2 more sources
Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs
Advanced Healthcare Materials, EarlyView.Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner +8 more
wiley +1 more source
Long-range 1H-15N J couplings providing a method for direct studies of the structure and azide-tetrazole equilibrium in a series of azido-1,2,4-triazines and azidopyrimidines [PDF]
, 2013 The selectively 15N labeled azido-1,2,4-triazine 2*A and azidopyrimidine 4*A were synthesized by treating hydrazinoazines with 15N-labeled nitrous acid.
Arseniev, A. S. +6 more
core +1 more source
Electrostatic Activation of Tetrazoles [PDF]
The Journal of Organic Chemistry, 2020 Photoactivation of tetrazoles to form nitrile imines primed for 1,3-dipolar cycloaddition reactions is of widespread utility in chemistry. In contrast, the corresponding thermal reactions usually possess prohibitively high barriers and have garnered significantly less attention.
Vincent Doan +2 more
openaire +3 more sources