Compound Library Screening Identified Cladribine as a Novel Radiosensitizer for Prostate Cancer
Cancer Science, EarlyView.The combination of cladribine and irradiation significantly suppressed the growth of DU145‐derived tumors compared with the DMSO plus irradiation group in the mouse model. In addition, it also elevated the percentage of γH2AX‐positive cells after irradiation.
Toshiki Oka +26 more
wiley +1 more source
A Crystallographic Study of a Novel Tetrazolyl-Substituted Nitronyl Nitroxide Radical
Crystals, 2018 Spin-labelled compounds are widely used in chemistry, physics, biology, and material sciences, but the directed synthesis of some functionalized organic radicals is still a challenge.
Vasily E. Romanov +6 more
doaj +1 more source
A facile route for the synthesis of novel S-linked 1,3,5-triazine tethered peptidomimetics [PDF]
, 2014 An efficient one-pot synthesis of Nα-protected S-linked 1,3,5-triazine tethered peptidomimetics is described. The protocol involves a three-component condensation reaction employing Nα-protected amino alkyl isothiouronium salt, formaldehyde and amino ...
Basavaprabhu, . +3 more
core +1 more source
Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides
Journal of Peptide Science, Volume 32, Issue 3, March 2026.As an alternative to the conventional approach, which combines amino acid monomers in a one‐by‐one fashion to peptide derivatives, the chemical modification of existing peptides has attracted significant attention in recent years. However, such approaches generally target the reactive functional groups in cysteine and lysine residues, particularly in ...
Yoshitaka Moriyama +2 more
wiley +1 more source
Design and Synthesis of a Novel N-(1H-tetrazol-5-yl)methyl Cyclic Peptoid Using Nosyl-protected N-(1-trityl-1H-tetrazol-5-yl)methyl Substituted Glycine [PDF]
, 2017 : A solid phase synthesis of a cyclic peptoid bearing (1H-tetrazol-5-yl)methyl as N-substituent has been developed employing the monomer approach.
Krishnamurthy, M. +4 more
core +1 more source
Tetrazoles via Multicomponent Reactions [PDF]
Chemical Reviews, 2019 Tetrazole derivatives are a prime class of heterocycles, very important to medicinal chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide moieties but also to their metabolic stability and other beneficial physicochemical properties.
Constantinos G. Neochoritis +2 more
openaire +3 more sources
Identifying Drugs Associated With Parkinson's Disease Risk Using Machine Learning
Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.ABSTRACT Machine learning (ML)–based methods have been proposed as a potential approach for identifying candidate drugs to be repurposed as disease‐modifying treatments for Parkinson's disease (PD). We applied an ML‐based signal detection method to identify drugs associated with PD and evaluated the method's generalizability.
Eeva Pylkkö +8 more
wiley +1 more source
Molecules, 2011 A straightforward and reliable method for the regioselective synthesis of steroidal 1,4-disubstituted triazoles and 1,5-disubstituted tetrazoles via copper(I)-catalyzed cycloadditions is reported. Heterocycle moieties were efficiently introduced onto the
János Wölfling +7 more
doaj +1 more source
Low temperature matrix-isolation and solid state vibrational spectra of 5-chlorotetrazole [PDF]
, 2002 The vibrational spectra of 5-chlorotetrazole (CN4HCl) isolated in an argon matrix (T ¼ 8.5 K) and in the solid state (at room temperature) were studied.
Bugalho, Susana C. S. +4 more
core +2 more sources
Intramolecular [3+2] Cycloaddition of Fused Azolo-Azepanes from Azido Monosaccharides Derivatives [PDF]
, 2016 Síntesis de bicíclicos compuestos empleando epoxiamidas como material de partida. Obtención de tetrazolo azepanos con posible actividad biológica.Universidad de Málaga.
Calvo-Losada, Saturnino +3 more
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