Results 71 to 80 of about 17,991 (268)
A Synthetic Route Toward Tetrazoles: The Thermolysis of Geminal Diazides
Chemistry, 2019 A new synthetic route toward the tetrazole core is described, which is based on a general fragmentation pattern that was found in a range of compounds featuring geminal diazido units.
K. Holzschneider +3 more
semanticscholar +1 more source
Chemistry – A European Journal, EarlyView.Ir/Ni metallaphotoredox system enables the regioselective α‐arylation and alkylation of N‐alkyl heterocycles via C(sp3)─H bond functionalization. This method bypasses traditional Sn2 pathways and offers complementary regioselectivity to transition metal catalysis.
Bin Lv +2 more
wiley +1 more source
Photochemical Synthesis of Pyrazolines from Tetrazoles in Flow
SynOpen, 2023 Pyrazolines and their pyrazole congeners are important heterocyclic building blocks with numerous applications in the fine chemical industries. However, traditional routes towards these entities are based on multistep syntheses generating substantial ...
Adam Burke +3 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.We designed and synthesized novel mannose‐6‐phosphate (M6P) derivatives to enhance their binding affinity for the CI‐M6P/IGF2 receptor, which plays a key role in lysosomal targeting. Using a fluorescence polarization assay, we evaluated di‐, tri‐, and penta‐M6P peptides and modified M6P analogs.
Lucie Mrázková +11 more
wiley +1 more source
Convergent approach towards ADP‐ribosylated‐peptides via a chemoselective phosphate condensation
Chemistry – A European Journal, Accepted Article.The preparation of well‐defined ADP‐ribosylated peptides is essential for studying the functional implications of this post‐translational modification. While methodologies exist for the chemical synthesis of short oligo‐ADPr fragments and mono‐ADP‐ribosylated peptides separately, combining the two distinct chemistries, required to assemble them, has ...
Sven Wijngaarden +9 more
wiley +1 more source
The Evolution of Fluorescein into A Potential Theranostic Tool
Chemistry – A European Journal, EarlyView.Our study successfully evolved a fluorescent imaging agent into a potent therapeutic compound. By functionalizing fluorescein, we enhanced its fluorescence and adapted it for multicomponent reactions (MCRs). We synthesized over 20 compounds across four diverse scaffolds.
Konstantinos S. Adamis +8 more
wiley +1 more source
Antimicrobial Agents and Chemotherapy, 2019 The fungal Cyp51-specific inhibitors VT-1161 and VT-1598 have emerged as promising new therapies to combat fungal infections, including Candida spp. To evaluate their in vitro activities compared to other azoles, MICs were determined by Clinical and ...
A. Nishimoto +10 more
semanticscholar +1 more source
Chemistry – A European Journal, Accepted Article.N,N‐Bis(trifluoromethyl)aminoacetonitrile (CF3)2NCH2CN (1) that is accessible via a simple single‐step protocol is established as building block for the introduction of the (CF3)2N group. The two reaction sites of 1, the methylene unit and the nitrile (cyano) group, provide access to different organic substance classes.
Kristina A. M. Maibom +14 more
wiley +1 more source
CHIMIA, 1975 Sodium azide or trimethylsilylazide react with N,N-dimethylphosgenimonium chloride by monosubstitution yielding N,N-dimethyl-azidochloromethylen-imonium chloride which can be isolated.
H.G. Viehe, P. George
doaj +1 more source
Flash Vacuum Pyrolysis of Azides, Triazoles, and Tetrazoles.
Chemical Reviews, 2017 Flash vacuum pyrolysis (FVP) of azides is an extremely valuable method of generating nitrenes and studying their thermal rearrangements. The nitrenes can in many cases be isolated in low-temperature matrices and observed spectroscopically. NH and methyl,
C. Wentrup
semanticscholar +1 more source