Results 81 to 90 of about 18,166 (271)
eAmidation: An Electrochemical Amidation of Aldehydes via the Oxidation of N‐Aryl Hydrazones
Advanced Synthesis &Catalysis, Volume 367, Issue 14, July 29, 2025.The indirect electrochemical oxidation of N‐aryl hydrazones offers an efficient approach to access amides from aldehydes and amines. The AZADO‐mediated reaction enables the selective synthesis of a broad range of valuable amides using readily available aldehydes.
Luke Chen +2 more
wiley +1 more source
Nature Communications, 2019 Asymmetric isocyanide-based multicomponent reactions are elegant, yet challenging, strategies to access valuable N-heterocycles. Here, the authors employ a chiral Mg(II) -N,N′-dioxide catalyst in three- or four-component reactions to obtain chiral ...
Qian Xiong +4 more
doaj +1 more source
Tetrazolium Compounds: Synthesis and Applications in Medicine
Molecules, 2015 Tetrazoles represent a class of five-membered heterocyclic compounds with polynitrogen electron-rich planar structural features. This special structure makes tetrazole derivatives useful drugs, explosives, and other functional materials with a wide range
Cheng-Xi Wei, Ming Bian, Guo-Hua Gong
doaj +1 more source
Chemistry – A European Journal, Volume 31, Issue 42, July 25, 2025.The retro‐Cope bioorthogonal reactivity of hydroxylamines was disabled transiently with a coumarin photolabile protecting group, which could be recovered upon removal of the protecting group by a short, 400 nm light illumination. Light‐controlled recovery of reactivity was demonstrated in bioorthogonal fluorescent labeling schemes of intracellular ...
Krisztina Németh +5 more
wiley +1 more source
Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology
Angewandte Chemie, Volume 137, Issue 28, July 7, 2025.Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker +3 more
wiley +2 more sources
Molecules, 2015 A series of five novel bis-1,5-disubstituted-1H-tetrazoles (bis-1,5-DS-1H-T) were quickly prepared by a catalyst-free Ugi-azide repetitive process from easily accessible starting materials in excellent yields, either at room temperature (88%–95%) or ...
Luís E. Cárdenas-Galindo +4 more
doaj +1 more source
Total Synthesis of Ectocarpin A
European Journal of Organic Chemistry, Volume 28, Issue 27, July 25, 2025.A fully enantioselective total synthesis of ectocarpin A, a new oxylipin, has been achieved in 12 steps starting from tetrahydro‐1H‐cyclopentafuranone. Key steps include the formation of the chiral core, diastereoselective epoxidation, enzymatic desymmetrization of a 1,4‐diol, epimerization, and strategic Wittig and Julia‐Kocienski olefinations to ...
Alexandre Guy +2 more
wiley +1 more source
An Efficient One-Pot Three-Component Synthesis of Novel Sulfanyl Tetrazoles Using Ionic Liquids
Journal of Chemistry, 2013 An efficient, simple, and environmentally benign method for the synthesis of novel sulfanyl tetrazoles has been achieved by one-pot three-component reaction of phenacyl bromides/3-(2-bromoacetyl)coumarins with KSCN and NaN3 using [Bmim]BF4 ionic liquid ...
Sankari Kanakaraju +2 more
doaj +1 more source
Chemistry – A European Journal, Volume 31, Issue 41, July 22, 2025.We designed and synthesized novel mannose‐6‐phosphate (M6P) derivatives to enhance their binding affinity for the CI‐M6P/IGF2 receptor, which plays a key role in lysosomal targeting. Using a fluorescence polarization assay, we evaluated di‐, tri‐, and penta‐M6P peptides and modified M6P analogs.
Lucie Mrázková +11 more
wiley +1 more source
Acta Crystallographica Section E, 2011 The title compound C6H12N4, is one of a few known tetrazoles with an alkyl chain in the 5-position. The asymmetric unit contains two independent molecules. The molecules are linked by N—H...N interactions into chains with graph-set notation D(2)
Heiner Detert +2 more
doaj +1 more source