SIRT1 and Estrogen Signaling Cooperation for Breast Cancer Onset and Progression
Frontiers in Endocrinology, 2018 Breast cancer remains a significant female mortality cause. It constitutes a multifactorial disease for which research on environmental factors offers little help in predicting onset or progression.
Sergio Liarte +2 more
doaj +1 more source
Upregulation of Id1 by Epstein-Barr Virus-encoded LMP1 confers resistance to TGFβ-mediated growth inhibition [PDF]
, 2010 Background Epstein-Barr virus (EBV)-encoded LMP1 protein is commonly expressed in nasopharyngeal carcinoma (NPC). LMP1 is a prime candidate for driving tumourigenesis given its ability to activate multiple signalling pathways and to alter the expression
Lo, Angela K. F. +4 more
core +2 more sources
Cancer Biology & Medicine, 2020 Objective: Bevacizumab is a recombinant humanized monoclonal antibody that blocks vascular endothelial growth factor (VEGF) with clear clinical benefits.
Xiaoling Zhang +9 more
doaj +1 more source
USP11 augments TGFβ signalling by deubiquitylating ALK5 [PDF]
Open Biology, 2012 Summary The TGFβ receptors signal through phosphorylation and nuclear translocation of SMAD2/3. SMAD7, a transcriptional target of TGFβ signals, negatively regulates the TGFβ pathway by recruiting E3 ubiquitin ligases and targeting TGFβ receptors for ...
Mazin A. Al-Salihi +3 more
doaj +1 more source
TGFβ impairs HNF1α functional activity in Epithelial-to-Mesenchymal Transition interfering with the recruitment of CBP/p300 acetyltransferases [PDF]
, 2019 The cytokine transforming growth factor β (TGFβ) plays a crucial role in the induction of both epithelial-to-mesenchymal transition (EMT) program and fibro-cirrhotic process in the liver, where it contributes also to organ inflammation following several ...
Amicone, Laura +8 more
core +1 more source
RADIOSENSITIZATION OF CANCER STEM CELLS: TARGETING TGFβ, NOTCH OR TELOMERASE TO IMPROVE TUMOR RESPONSE O RADIOTHERAPY [PDF]
American Medical Journal, 2014 Radiation resistant cancer stem cells are the main reason for treatment failure and tumor recurrence after cancer radiotherapy. Increasing biological evidences demonstrate that these cells possess the capacity to repair radiation induced DNA damage, protect themselves from radiation derived reactive oxygen species, survive and proliferate after several
openaire +1 more source
OncoImmunology, 2021 Most monoclonal antibodies (MAbs), including immune checkpoint inhibitor MAbs, are delivered intravenously (i.v.) to patients. Recent clinical studies have demonstrated that some anti-PD1 MAbs may also be delivered subcutaneously (s.c.), with clinical ...
Yohei Ozawa +5 more
doaj +1 more source
A two-compartment mechanochemical model of the roles of\ud transforming growth factor β and tissue tension in dermal wound healing [PDF]
, 2011 The repair of dermal tissue is a complex process of interconnected phenomena, where cellular, chemical and mechanical aspects all play a role, both in an autocrine and in a paracrine fashion.
Hall, C. L. +4 more
core +3 more sources
Comparison of the anti-inflammatory and antilipidemic activity of diosmin and saroglitazar in a model of nonalcoholic fatty liver induced by a high-fat diet in Wistar rats [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Non-alcoholic fatty liver disease (NAFLD) is the most common liver-related metabolic disorder in the world, with a global prevalence of 25%.
Reza Afarin +6 more
doaj +1 more source
TGFβ-facilitated optic fissure fusion and the role of bone morphogenetic protein antagonism [PDF]
Open Biology, 2018 The optic fissure is a transient gap in the developing vertebrate eye, which must be closed as development proceeds. A persisting optic fissure, coloboma, is a major cause for blindness in children.
Max D. Knickmeyer +8 more
doaj +1 more source