Th1, Th2, and Th17 cytokines in systemic lupus erythematosus
Autoimmunity, 2020 Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the breakdown of immune tolerance leading to excessive inflammation and tissue damage.
Farhana Muhammad Yusoff +2 more
doaj +2 more sources
Evaluation of IFN-γ and T-bet Expression Levels as Possible Molecular Markers of Schizophrenia [PDF]
Journal of Cell and Molecular Research, 2020 Schizophrenia is an irritating mental disorder that affects around 1% of the world's population. The immune system contributes to the onset of the disease, particularly through production and secretion of some cytokines.
Roghaye Lorestani +3 more
doaj +1 more source
T helper cell subsets and related target cells in acute COVID-19
Инфекция и иммунитет, 2022 Current review presents a brief overview of the immune system dysregulation during acute COVID-19 and illustrates the main alterations in peripheral blood CD4+ T-cell (Th) subsets as well as related target cells.
I. V. Kudryavtsev +2 more
doaj +1 more source
Review – Helicobacter: inflammation, immunity and vaccines [PDF]
Microbiota in Health and Disease, 2021 Helicobacter pylori is a bacterium that colonizes the human stomach and is the risk factor for severe gastroduodenal diseases, such as gastric cancer, gastric lymphoma, autoimmune gastritis and peptic ulcer. H.
M. D’Elios, M. de Bernard
doaj +1 more source
Российский кардиологический журнал, 2022 Aim. To analyze the relationship of blood lipid profile parameters, including the level of lipoprotein(a) (Lp(a)), and the content of circulating CD4+ T-lymphocytes with premature coronary artery disease (CAD).Material and methods.
A. Yu. Filatova +6 more
doaj +1 more source
Recent advances in understanding the Th1/Th2 effector choice
Faculty Reviews, 2021 For over 35 years since Mosmann and Coffman proposed the seminal “type 1 T helper (Th1)/type 2 T helper (Th2)” hypothesis in 1986, the immunological community has appreciated that naïve CD4 T cells need to make important decisions upon their activation ...
M. Butcher, Jinfang Zhu
semanticscholar +1 more source
Comparative Analysis of Apigenin-3 Acetate versus Apigenin and Methyl-Prednisolone in Inhibiting Proliferation and Gene Expression of Th1 Cells in Multiple Sclerosis [PDF]
Cell Journal, 2023 Objective: In spite of the advances in therapeutic modalities, morbidity, due to multiple sclerosis (MS), still remains high.Therefore, a large body of research is endeavouring to discover or develop novel therapies with improved efficacy fortreating MS ...
Neda Kasiri +7 more
doaj +1 more source
Th2/Th1 Cytokine Imbalance Is Associated With Higher COVID-19 Risk Mortality
Frontiers in Genetics, 2021 A major component of COVID-19 severe respiratory syndrome is the patient’s immune response to the SARS-CoV-2 virus and the consequential multi-organ inflammatory response.
A. Pavel +5 more
semanticscholar +1 more source
Game theory applications in host-microbe interactions toward disease manifestation: Mycobacterium tuberculosis infection as an example [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Game theory describes the interactions between two players and the pay-off from winning, losing, or compromising. In the present study, Mycobacterium tuberculosis (Mtb)–host interactions were used as an example for the application of game ...
Hiva Sharebiani +11 more
doaj +1 more source
In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm.
Annual Review of Immunology, 2020 The discovery of CD4+ T cell subset-defining master transcription factors and framing of the Th1/Th2 paradigm ignited the CD4+ T cell field.
Mikel Ruterbusch +3 more
semanticscholar +1 more source