Results 41 to 50 of about 319,332 (247)

The significance of Th1,Th2,Th17and treg cells in the prediction and evaluation of ulcerative colitis

European Journal of Inflammation, 2023
Objective This study aimed to investigate clinical significance of Th1, Th2, Th17 and Tregs proportions in predicting and evaluating UC. Methods A total of 101 UC patients diagnosed by the Department of Gastroenterology of the Shanxi Provincial People’s ...
Yu Zhang, Wei Shi, Gaigai Cao, Jingru Li, Haijiao Wang, Chonghua Hao   +5 more
doaj   +1 more source

Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation. [PDF]

PLoS Biology, 2013
Differentiated T helper (Th) cell lineages are thought to emerge from alternative cell fate decisions. However, recent studies indicated that differentiated Th cells can adopt mixed phenotypes during secondary immunological challenges.
Michael Peine, Sebastian Rausch, Caroline Helmstetter, Anja Fröhlich, Ahmed N Hegazy, Anja A Kühl, Christoph G Grevelding, Thomas Höfer, Susanne Hartmann, Max Löhning   +9 more
doaj   +1 more source

Evaluation of Th1 and TH2 Cytokine Network in Aspergilus Infected Tumor Bearing Mice [PDF]

Journal of Advanced Biomedical Sciences, 2012
Background & Objective: Invasive Aspergillosis is a fatal infection in immunocompromised patients. The aim of this study was to evaluate the interaction of infectious with Aspergillus and tumor on immune response and cytokine network in Aspergillus ...
Noushin Sohrabi, Majid Tebyanyan, Mehdi Mahdavi   +2 more
doaj  

Immune response to inactivated bacterial vector carrying the recombinant K39 antigen of Leishmania infantum in mice

Asian Pacific Journal of Tropical Biomedicine
Objective: To evaluate the immunological response elicited by an inactivated bacterial vector carrying the K39 antigen of Leishmania infantum, and a purified antigen. Methods: Mice were subjected to the following treatments: (1) Purified recombinant K39 (
Araújo Lucelina S., Silva Bruno B., Santos Eduarda N. F. N., Bezerra Arnaldo S., Frota Samuel S., Montenegro Assis R., Florean Eridan O. P. T., van Tilburg Maurício F., Guedes Maria Izabel F.   +8 more
doaj   +1 more source

Development of a preclinical model of myeloid tumors with high immune checkpoints expression

Онкогематология
Background. Myelodysplastic syndrome is a group of malignant blood diseases with a high risk of transformation into acute myeloid leukemia. One treatment approach is to target immune checkpoints (ICs) that are overexpressed on tumor cells.
D. A. Senichkina, A. I. Shakirova, O. S. Epifanovskaya, I. N. Gaponenko, T. A. Pyatiizbyantsev, E. V. Belotserkovskaya, A. B. Malyshecheva, K. V. Lepik, I. S. Moiseev   +8 more
doaj   +1 more source

Increased Th1 Cells with Disease Resolution of Active Pulmonary Tuberculosis in Non-Atopic Patients

Biomedicines, 2021
Type 1 CD4+ T helper (Th1) cells mediate resistance to Mycobacterium tuberculosis (Mtb), and Th2 immunity generates specific immunoglobulin E upon allergen exposure.
Chun-Yu Lo, Yu-Chen Huang, Hung-Yu Huang, Fu-Tsai Chung, Chang-Wei Lin, Kian Fan Chung, Chun-Hua Wang   +6 more
doaj   +1 more source

Supplementary Table 1 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8⁺ T Cells [PDF]

, 2023
Jérémy Goc, Claire Germain, Thi Kim Duy Vo-Bourgais, Audrey Lupo, Christophe Klein, Samantha Knockaert, Luc de Chaisemartin, Hanane Ouakrim, Étienne Becht, Marco Alifano, Pierre Validire, Romain Remark, Scott A. Hammond, Isabelle Cremer, Diane Damotte, Wolf H. Fridman, Catherine Sautès‐Fridman, Marie‐Caroline Dieu‐Nosjean   +17 more
openalex   +1 more source

Distinct prognostic value of circulating anti-telomerase CD4+ Th1 immunity and exhausted PD-1+/TIM-3+ T cells in lung cancer

British Journal of Cancer, 2019
Despite the critical roles of Th1-polarised CD4+ T cells in cancer immunosurveillance, the translation of their potential to clinical use remains challenging.
C. Laheurte, M. Dosset, D. Vernerey, L. Boullerot, B. Gaugler, E. Gravelin, V. Kaulek, M. Jacquin, L. Cuche, Guillaume Eberst, P. Jacoulet, E. Fabre, F. Le Pimpec-Barthes, E. Tartour, M. De Carvalho Bittencourt, V. Westeel, O. Adotévi   +16 more
semanticscholar   +1 more source

Incidental Thoracic Th1 Spina Bifida Occulta Detection Following Sports Injury: A Case Report with Comprehensive Radiological Insights

Journal of Orthopaedic Case Reports
Introduction: Spina bifida is a neural tube defect and the incidence in the thoracic region is extremely rare. We reported an incidental finding of thoracic spina bifida occulta at the first thoracic vertebra following a sport-related injury. Case Report:
Sinan Kara, Amel Gorani, Bruno Baillon, Alexandre Grandjean, Thomas Von Waldburg, Tevi Morel Lawson   +5 more
doaj   +1 more source

Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration. [PDF]

PLoS ONE, 2012
c-Src activates Ras-MAPK/ERK signaling pathway and regulates cell migration, while trihydrophobin 1 (TH1) inhibits MAPK/ERK activation and cell migration through interaction with A-Raf and PAK1 and inhibiting their kinase activities.
Weibin Wu, Zhichao Sun, Jingwen Wu, Xiaomin Peng, Huacheng Gan, Chunyi Zhang, Lingling Ji, Jianhui Xie, Haiyan Zhu, Shifang Ren, Jianxin Gu, Songwen Zhang   +11 more
doaj   +1 more source