Results 61 to 70 of about 319,332 (247)
OncoImmunology, 2019 Sipuleucel-T is the only FDA-approved immunotherapy for metastatic castration-resistant prostate cancer. The mechanism by which this treatment improves survival is not fully understood.
Katsunobu Hagihara +6 more
doaj +1 more source
Common Features of Regulatory T Cell Specialization During Th1 Responses
Frontiers in Immunology, 2018 CD4+Foxp3+ Treg cells are essential for maintaining self-tolerance and preventing excessive immune responses. In the context of Th1 immune responses, co-expression of the Th1 transcription factor T-bet with Foxp3 is essential for Treg cells to control ...
Katharina Littringer +14 more
doaj +1 more source
Nature Communications, 2018 Chitinase-3-like-1 (Chi3l1) is known to play a significant role in the pathogenesis of Type 2 inflammation and cancer. However, the function of Chi3l1 in T cell and its clinical implications are largely unknown.
Do-Hyun Kim +12 more
semanticscholar +1 more source
Erythromycin Prevents Elastin Peptide-Induced Emphysema and Modulates CD4+T Cell Responses in Mice
International Journal of COPD, 2019 Shudan Tang,* Tingting Ma,* Hui Zhang,* Jianquan Zhang, Xiaoning Zhong, Caimei Tan, Ye Qiu, Wen Zeng, Xin Feng Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, People’s ...
Tang S +8 more
doaj
Cell Reports, 2017 Recent data indicate that the differentiation state of Th1 cells determines their protective capacity against tuberculosis. Therefore, we examined the role of Th1-polarizing factors in the generation of protective and non-protective subsets of Mtb ...
Michelle A. Sallin +5 more
doaj +1 more source
Enhanced Rg3 negatively regulates Th1 cell responses
Journal of Ginseng Research, 2019 Background: Korean Red Ginseng (KRG; Panax ginseng Meyer) is a widely used medicinal herb known to exert various immune modulatory functions. KRG and one of its purified components, ginsenoside Rg3, are known to possess anti-inflammatory activities.
Minkyoung Cho +3 more
doaj +1 more source
Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties
Journal of Neuroinflammation, 2017 Autoreactive Th1 and Th17 cells are believed to mediate the pathology of multiple sclerosis in the central nervous system (CNS). Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of the neuroinflammation. Previously,
C. K. Prajeeth +10 more
semanticscholar +1 more source
PLoS ONE, 2017 Bile acids are established signaling molecules next to their role in the intestinal emulsification and uptake of lipids. We here aimed to identify a potential interaction between bile acids and CD4+ Th cells, which are central in adaptive immune ...
T. Pols +5 more
semanticscholar +1 more source
IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation
Scientific Reports, 2017 IL-10 is an immunomodulatory cytokine with a critical role in limiting inflammation in immune-mediated pathologies. The mechanisms leading to IL-10 expression by CD4+ T cells are being elucidated, with several cytokines implicated. We explored the effect
Ruth E. Mitchell +6 more
semanticscholar +1 more source
JCI Insight, 2021 Oligoarticular juvenile idiopathic arthritis (oligo JIA) is the most common form of chronic inflammatory arthritis in children, yet the cause of this disease remains unknown. To understand immune responses in oligo JIA, we immunophenotyped synovial fluid
Amélie M. Julé +24 more
doaj +1 more source