Results 61 to 70 of about 230,695 (309)

Subjectivity, historical imagination and the language of art history [PDF]

Journal of Art Historiography, 2020
Analysing the writings of Michael Baxandall, Michael Ann Holly, Adrian Stokes and T. J. Clark, and responding to recent art historiographical interest in the foregrounding of subjectivity, this essay deploys Baxandall’s analysis of the verbal description
Thomas Hughes
doaj  

The Five Elements of Th1-Th2 System [PDF]

arXiv, 2008
The T helper (Th) phenotypes, Th1/Th2, are acquired upon interaction of a naive T helper cell and an antigen presenting cell (APC). Naive T helper cells may differentiate into either phenotype, and the actual outcome is determined by the density and avidity of the antigenic determinants presented by the APC, and the APCs inherent costimulatory ...
arxiv  

Short‐chain fatty acids in multiple sclerosis: Associated with disability, number of T2 lesions, and inflammatory profile

Annals of Clinical and Translational Neurology, Volume 12, Issue 3, Page 478-490, March 2025.
Abstract Objective An alteration in the composition of the intestinal microbiota has been observed in patients with multiple sclerosis (pwMS) with respect to healthy controls (HC). Microorganism‐derived metabolites such as short‐chain fatty acids (SCFA) have been suggested to play a role in the disease.
Maria Inmaculada Dominguez‐Mozo, Daniel López‐Mecández, Luisa María Villar, Lucienne Costa‐Frossard, Noelia Villarrubia, Yolanda Aladro, Belén Pilo, Xavier Montalbán, Manuel Comabella, Ignacio Casanova‐Peño, Inés González‐Suárez, María Luisa Martínez‐Ginés, Jose Manuel García‐Domínguez, Estefanía García‐Calvo, Andrés Machuca‐Marcos, Jose Luis Luque‐Garcia, María Angel Garcia‐Martinez, Rafael Arroyo, Roberto Alvarez‐Lafuente   +18 more
wiley   +1 more source

Erythromycin Prevents Elastin Peptide-Induced Emphysema and Modulates CD4+T Cell Responses in Mice

International Journal of COPD, 2019
Shudan Tang,* Tingting Ma,* Hui Zhang,* Jianquan Zhang, Xiaoning Zhong, Caimei Tan, Ye Qiu, Wen Zeng, Xin Feng Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, People’s ...
Tang S, Ma T, Zhang H, Zhang J, Zhong X, Tan C, Qiu Y, Zeng W, Feng X   +8 more
doaj  

Development of a preclinical model of myeloid tumors with high immune checkpoints expression

Онкогематология
Background. Myelodysplastic syndrome is a group of malignant blood diseases with a high risk of transformation into acute myeloid leukemia. One treatment approach is to target immune checkpoints (ICs) that are overexpressed on tumor cells.
D. A. Senichkina, A. I. Shakirova, O. S. Epifanovskaya, I. N. Gaponenko, T. A. Pyatiizbyantsev, E. V. Belotserkovskaya, A. B. Malyshecheva, K. V. Lepik, I. S. Moiseev   +8 more
doaj   +1 more source

Specific T cell induction using iron oxide based nanoparticles as subunit vaccine adjuvant

Human Vaccines & Immunotherapeutics, 2018
Metal-based nanoparticles (NPs) stimulate innate immunity; however, they have never been demonstrated to be capable of aiding the generation of specific cellular immune responses. Therefore, our objective was to evaluate whether iron oxide-based NPs have
Lázaro Moreira Marques Neto, Nicholas Zufelato, Ailton Antônio de Sousa-Júnior, Monalisa Martins Trentini, Adeliane Castro da Costa, Andris Figueiroa Bakuzis, André Kipnis, Ana Paula Junqueira-Kipnis   +7 more
doaj   +1 more source

Common Features of Regulatory T Cell Specialization During Th1 Responses

Frontiers in Immunology, 2018
CD4+Foxp3+ Treg cells are essential for maintaining self-tolerance and preventing excessive immune responses. In the context of Th1 immune responses, co-expression of the Th1 transcription factor T-bet with Foxp3 is essential for Treg cells to control ...
Katharina Littringer, Claudia Moresi, Nikolas Rakebrandt, Xiaobei Zhou, Xiaobei Zhou, Michelle Schorer, Tamas Dolowschiak, Florian Kirchner, Felix Rost, Christian W. Keller, Donal McHugh, Salomé LeibundGut-Landmann, Mark D. Robinson, Mark D. Robinson, Nicole Joller   +14 more
doaj   +1 more source

Allergen challenge induces Ifng dependent GTPases in the lungs as part of a Th1 transcriptome response in a murine model of allergic asthma. [PDF]

PLoS ONE, 2009
According to the current paradigm, allergic airway inflammation is mediated by Th2 cytokines and pro-inflammatory chemokines. Since allergic inflammation is self-limited, we hypothesized that allergen challenge simultaneously induces anti-inflammatory ...
Nilesh Dharajiya, Swapnil Vaidya, Mala Sinha, Bruce Luxon, Istvan Boldogh, Sanjiv Sur   +5 more
doaj   +1 more source

Modeling the influence of TH1 and TH2 type cells in autoimmune diseases [PDF]

arXiv, 2000
A sharp TH1/TH2 dichotomy has often been used to define the effects of cytokines on autoimmune diseases. However contradictory results in recent research indicate that the situation may be more complex. We build here a simple mathematical model aimed at settling the contradictions.
arxiv  

CSF cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (GFAP) autoimmunity

Annals of Clinical and Translational Neurology, Volume 12, Issue 4, Page 855-860, April 2025.
Abstract Defining the CSF cytokine/chemokine and injury biomarker signature of glial fibrillary acidic protein (GFAP) autoimmunity can inform immunopathogenesis. CSF GFAP‐IgG‐positive samples (N = 98) were tested for 17 cytokines/chemokines, neurofilament light chain (NfL), and GFAP (ELLA, Bio‐Techne).
Yahel Segal, Georgios Mangioris, Vanda Lennon, Binxia Yang, Divyanshu Dubey, Eoin P. Flanagan, Andrew McKeon, John R. Mills, Michel Toledano, Ivana Vodopivec, Sean J. Pittock, Anastasia Zekeridou   +11 more
wiley   +1 more source