Results 81 to 90 of about 528,953 (331)

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration. [PDF]

PLoS ONE, 2012
c-Src activates Ras-MAPK/ERK signaling pathway and regulates cell migration, while trihydrophobin 1 (TH1) inhibits MAPK/ERK activation and cell migration through interaction with A-Raf and PAK1 and inhibiting their kinase activities.
Weibin Wu, Zhichao Sun, Jingwen Wu, Xiaomin Peng, Huacheng Gan, Chunyi Zhang, Lingling Ji, Jianhui Xie, Haiyan Zhu, Shifang Ren, Jianxin Gu, Songwen Zhang   +11 more
doaj   +1 more source

Increased Th1 Cells with Disease Resolution of Active Pulmonary Tuberculosis in Non-Atopic Patients

Biomedicines, 2021
Type 1 CD4+ T helper (Th1) cells mediate resistance to Mycobacterium tuberculosis (Mtb), and Th2 immunity generates specific immunoglobulin E upon allergen exposure.
Chun-Yu Lo, Yu-Chen Huang, Hung-Yu Huang, Fu-Tsai Chung, Chang-Wei Lin, Kian Fan Chung, Chun-Hua Wang   +6 more
doaj   +1 more source

Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure

Journal of Experimental Medicine, 2017
Despite emerging data indicating a role for T cells in profibrotic cardiac repair and healing after ischemia, little is known about whether T cells directly impact cardiac fibroblasts (CFBs) to promote cardiac fibrosis (CF) in nonischemic heart failure ...
T. Nevers, Ane M. Salvador, Francisco E. Velázquez, Njabulo Ngwenyama, F. Carrillo-Salinas, M. Aronovitz, Robert M. Blanton, P. Alcaide   +7 more
semanticscholar   +1 more source

Impact of Th1 CD4 Follicular Helper T Cell Skewing on Antibody Responses to an HIV-1 Vaccine in Rhesus Macaques. [PDF]

, 2020
Generating durable humoral immunity through vaccination depends upon effective interactions of follicular helper T (Tfh) cells with germinal center (GC) B cells.
Amara, Rama R, Beck, Zoltan, Dinasarapu, Ashok R, Elizaldi, Sonny R, Foehl, David H, Forthal, Donald N, Gach, Johannes S, Iyer, Smita S, Kozlowski, Pamela A, LaBranche, Celia C, Lakshmanappa, Yashavanth Shaan, Matyas, Gary R, Nguyen, Nancy K, Rane, Niharika N, Rao, Mangala, Reimann, Keith A, Schmidt, Brian A, Shen, Xiaoying, Tomaras, Georgia D, Trinh, Hung V, Verma, Anil, Walter, Korey A   +21 more
core  

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Incidental Thoracic Th1 Spina Bifida Occulta Detection Following Sports Injury: A Case Report with Comprehensive Radiological Insights

Journal of Orthopaedic Case Reports
Introduction: Spina bifida is a neural tube defect and the incidence in the thoracic region is extremely rare. We reported an incidental finding of thoracic spina bifida occulta at the first thoracic vertebra following a sport-related injury. Case Report:
Sinan Kara, Amel Gorani, Bruno Baillon, Alexandre Grandjean, Thomas Von Waldburg, Tevi Morel Lawson   +5 more
doaj   +1 more source

Specific T cell induction using iron oxide based nanoparticles as subunit vaccine adjuvant

Human Vaccines & Immunotherapeutics, 2018
Metal-based nanoparticles (NPs) stimulate innate immunity; however, they have never been demonstrated to be capable of aiding the generation of specific cellular immune responses. Therefore, our objective was to evaluate whether iron oxide-based NPs have
Lázaro Moreira Marques Neto, Nicholas Zufelato, Ailton Antônio de Sousa-Júnior, Monalisa Martins Trentini, Adeliane Castro da Costa, Andris Figueiroa Bakuzis, André Kipnis, Ana Paula Junqueira-Kipnis   +7 more
doaj   +1 more source

Distinct prognostic value of circulating anti-telomerase CD4+ Th1 immunity and exhausted PD-1+/TIM-3+ T cells in lung cancer

British Journal of Cancer, 2019
Despite the critical roles of Th1-polarised CD4+ T cells in cancer immunosurveillance, the translation of their potential to clinical use remains challenging.
C. Laheurte, M. Dosset, D. Vernerey, L. Boullerot, B. Gaugler, E. Gravelin, V. Kaulek, M. Jacquin, L. Cuche, Guillaume Eberst, P. Jacoulet, E. Fabre, F. Le Pimpec-Barthes, E. Tartour, M. De Carvalho Bittencourt, V. Westeel, O. Adotévi   +16 more
semanticscholar   +1 more source

IL‐2 Free Expansion of T Cells with Immunofilaments

Advanced Healthcare Materials, EarlyView.
Ratio and density of stimulatory αCD3 and αCD28 mAb on immunofilaments (IF) influence T cell expansion, cytokine production, and effector phenotype. Moreover, IL‐2 supplementation is not necessary with optimal performing IFs, which leads to simpler culture conditions, and negative side effects of IL‐2 supplementation are reduced.
Marjolein Schluck, Lea Weiss, René Classens, Carl G. Figdor, Roel Hammink   +4 more
wiley   +1 more source