Results 111 to 120 of about 169,698 (304)
Treg/Th17 balance of ITP patients skewed toward Th17.
, 2013 A. Representative dot plots of Treg cells (CD4+CD25hiFoxp3+ cells) in NC, OB and RT group. B. Representative dot plots of Th17 cells (CD3+CD4+IL-17+ cells) in NC, OB and RT group. C. The mean ± SD of the percentage of Treg cells in different group.
Feng Li (30515) +9 more
core +1 more source
Advanced Science, EarlyView.In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia +15 more
wiley +1 more source
The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity
Cell ReportsGlucose metabolism is a critical regulator of T cell function, largely thought to support their activation and effector differentiation. Here, we investigate how individual glycolytic reactions determine the pathogenicity of T helper 17 (Th17) cells using Compass, an algorithm we previously developed for inferring metabolic states from single-cell RNA ...
Chao Wang +10 more
openaire +3 more sources
The mechanism of how miR-155 regulates Treg/Th17 cells differentiation and Th17 cell function.
, 2013 A. Signaling pathways that are involved in regulating Treg and Th17 cells differentiation and function. IL-2 and TGF-β1 induce the differentiation of Treg cells by enhancing the expression of phospho (p)-STAT5 and p-SMAD5, respectively.
Yu-Lan Ma (302641) +6 more
core +1 more source
Advanced Science, EarlyView.Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu +6 more
wiley +1 more source
Modes of the initiation of T cell-mediated immune responses
Medical ReviewT cell-mediated immune response is the center of adaptive immunity. Despite more than five decades of research, the knowledge of mechanisms drives the initiation of T cell-mediated immune response is still limited due to the complexity of T cell-mediated
Li Long, Yao Zhi
doaj +1 more source
IL-17 and Th17 cells in systemic sclerosis: a comprehensive review
Romanian Journal of Internal Medicine, 2017 T cells (especially T helper cells) seem to be strongly associated with systemic sclerosis pathogenesis. Th17-IL-17 axis was proved to be involved in the pathogenesis of multiple autoimmune diseases.
Bălănescu Paul +2 more
doaj +1 more source
Th17 Cells in Inflammatory Conditions [PDF]
The Review of Diabetic Studies, 2006 CD4(+) T cells have been subdivided into different subsets, largely on the basis of the cytokines they produce. These subsets include Th1, Th2 and regulatory T cells. Recently, another population of T cells have been described, namely Th17, which are characterized by their production of IL-17.
openaire +2 more sources
Th17 cells: inflammation and regulation [PDF]
, 2014 IL-17-producing CD4+ T cells (Th17 cells) are understood to be a distinct lineage of CD4+ T helper (Th) cells, which play an important role in the host defense, tissue inflammation and autoimmunity.
Kishimoto, T, Masuda, K
core +1 more source
FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape
Advanced Science, EarlyView.FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu +14 more
wiley +1 more source