Results 91 to 100 of about 169,698 (304)

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Ratios of TH17/CD4⁺CD25^high, TH17/Tregs and TH1/TH2 cells.

, 2014
Ratios of Th17/CD4+CD25high and Th17/CD4+CD25highCD127lowFoxP3+ were significantly decreased in CLBP patients as compared to healthy controls (Th17/CD4+CD25high: 0.12±0.08 in CLBP patients vs.
Banafscheh Rachinger-Adam (615815), Patrick Möhnle (615818), Simone Kreth (355824), Benjamin Luchting (615814), Julia Zeitler (615816), Lisa Egenberger (615817), Shahnaz Christina Azad (94275)   +6 more
core   +1 more source

MiR-206 regulates the Th17/Treg ratio during osteoarthritis

, 2021
Background The present study aimed to determine the functional role of miR-206 in T helper 17 (Th17)/regulatory T (Treg) cell differentiation during the development of osteoarthritis (OA).
Wei Xie, Jun Rao, Weijun Wang, Hao Li, Zhiwen Zhang, Qilin Lu, Chengjian He, Xiguang Ye, Aofei Yang   +8 more
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Inflammatory Cytokine: IL-17A Signaling Pathway in Patients Present with COVID-19 and Current Treatment Strategy

Journal of Inflammation Research, 2020
Tewodros Shibabaw Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Tewodros ShibabawDepartment of Biochemistry, School of Medicine, University of Gondar, P.O ...
Shibabaw T
doaj  

Th17 cell frequencies and Th17/Treg ratio in HICs and control groups.

, 2020
Frequencies of Th17 cells (CD4+IL17+) among the studied groups are shown in the graph. (B) Th17/Treg ratios are shown in the graph. The Th17/Treg ratio was calculated by using the frequencies of both populations concerning the CD4+ compartment.
Diogo G. Caetano (5500967), Gonzalo Bello (138839), Mariza G. Morgado (8407509), Larissa M. Villela (8407506), Monick L. Guimarães (8407512), Valdilea G. Veloso (2833304), Beatriz Grinsztejn (116216), Hury H. S. de Paula (5500964), Brenda Hoagland (538356), Fernanda H. Côrtes (5500961)   +9 more
core   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Th1, Th2, and Th17 cytokines in systemic lupus erythematosus

Autoimmunity, 2020
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the breakdown of immune tolerance leading to excessive inflammation and tissue damage.
Farhana Muhammad Yusoff, Kah Keng Wong, Norhanani Mohd Redzwan   +2 more
doaj   +1 more source

The frequency of Tregs, the frequency of Th17 cells, and Tregs/Th17 ratio are correlated with RAI.

, 2014
To confirm whether Tregs, Th17 cells and Tregs/Th17 were associated with the liver allograft rejection, we analyzed the correlation between RAI and the frequency of circulating Tregs, the frequency of circulating Th17 cells, and Tregs/Th17 ratio.
Fu-Sheng Wang (300650), Yan-Ling Sun (654787), Yan-Chao Shi (654786), Ming Shi (78991), Zhen-Wen Liu (654784), Hong-Bo Wang (450965), Lei Jin (120473), Ying Wang (11406), Min Zhang (111999), Wei-Guo Ren (654785)   +9 more
core   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source