Results 81 to 90 of about 169,698 (304)

Treg/Th17 relationship during candidiasis.

, 2014
Tregs promote Th17 responses as well as acquire Th17 characteristics during disseminated infection. However, Treg/Th17 responses are associated with pathogenicity in this form of candidiasis.
Sarah L. Gaffen (366308), Natasha Whibley (669852)   +1 more
core   +1 more source

Human gut bacterial metabolism drives Th17 activation and colitis

, 2021
Bacterial activation of T helper 17 (Th17) cells exacerbates mouse models of autoimmunity, but how human-associated bacteria impact Th17-driven disease remains elusive.
Pollard, Katherine S., Bustion, Annamarie E, Sandy, Moriah, Lynch, Susan V, Bustion, Annamarie E., Zhang, Bing, Alexander, Margaret, Turnbaugh, Peter J., Turnbaugh, Peter J, Upadhyay, Vaibhav, Nayak, Renuka R, Nayak, Renuka R., Lynch, Susan V., Pollard, Katherine S, Ang, Qi Yan, Moriah Sandy, Peter J. Turnbaugh, Katherine S. Pollard, Renuka R. Nayak, Annamarie E. Bustion, Qi Yan Ang, Vaibhav Upadhyay, Susan V. Lynch, Margaret Alexander, Bing Zhang   +24 more
core   +1 more source

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

Features of peripheral blood Treg and Th17 subsets during physiological pregnancy [PDF]

Exploration of Immunology
Aim: Regulatory T (Treg) cells and interleukin-17-producing T helper (Th17) cells play a critical role in successful pregnancy. Treg and Th17 cells differentiate predominantly in the thymus.
Olga Gorbunova, Ekaterina Orlova, Olga Loginova, Sergey Shirshev   +3 more
doaj   +1 more source

Th17 cell responses in spondyloarthritis

Best Practice & Research Clinical Rheumatology, 2017
Targeting IL-17 has become an important option in the current treatment of spondyloarthritis (SpA). To place this therapeutic advancement in context, we review the discovery and properties of this cytokine, noting those which predispose to inflammation and led to it being considered as an attractive target for the treatment of arthritis, especially SpA.
Gaston, JSH, Jadon, DR
openaire   +3 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Erythromycin Prevents Elastin Peptide-Induced Emphysema and Modulates CD4+T Cell Responses in Mice

International Journal of COPD, 2019
Shudan Tang,* Tingting Ma,* Hui Zhang,* Jianquan Zhang, Xiaoning Zhong, Caimei Tan, Ye Qiu, Wen Zeng, Xin Feng Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, People’s ...
Tang S, Ma T, Zhang H, Zhang J, Zhong X, Tan C, Qiu Y, Zeng W, Feng X   +8 more
doaj  

How to treat a patient with psoriatic arthritis and chronic lymphocytic leukemia? [PDF]

Exploration of Musculoskeletal Diseases
A 76-year-old male patient who has been suffering from psoriatic arthritis (PsA) for 15 years was diagnosed with chronic lymphocytic leukemia (CLL) 18 months ago.
Jürgen Braun, Kirsten Karberg, Denis Poddubnyy   +2 more
doaj   +1 more source

Th17 Cells in Immunity and Autoimmunity [PDF]

Clinical and Developmental Immunology, 2013
Th17 and IL-17 play important roles in the clearance of extracellular bacterial and fungal infections. However, strong evidence also implicates the Th17 lineage in several autoimmune disorders including multiple sclerosis, psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma.
Simone Kennedy Bedoya, Brandon Lam, Kenneth Lau, Joseph Larkin   +3 more
openaire   +3 more sources

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source