Results 101 to 110 of about 169,698 (304)
Histopathologic and immunological features of Imiquimod induced psoriatic mouse model
Pifu-xingbing zhenliaoxue zazhi, 2019 Objective: To investigate the dermatopathologic and immunological features of Imiquimod induced psoriatic mice model. Methods: Twenty BALB/c mice were grouped in IMQ-model group and control group randomly, each had 10 mice.
Zhong-zhou HUANG +5 more
doaj +1 more source
TH17-ФЕНОТИП ЮВЕНИЛЬНОГО ИДИОПАТИЧЕСКОГО АРТРИТА [PDF]
, 2015 Urgency. Juvenile idiopathic arthritis (JIA) remains one of the most urgent issues of pediatric rheumatology due to incapacitation at early stages of the disease.
Н. М. Калинина +9 more
core +1 more source
TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis
Advanced Science, EarlyView.A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu +12 more
wiley +1 more source
PTEN drives Th17 cell differentiation by preventing IL-2 production
, 2017 T helper 17 (Th17) cells are a CD4+ T cell subset that produces IL-17A to mediate inflammation and autoimmunity. IL-2 inhibits Th17 cell differentiation. However, the mechanism by which IL-2 is suppressed during Th17 cell differentiation remains unclear.
Sung Woong Jang +6 more
core +1 more source
Advanced Science, EarlyView.An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang +8 more
wiley +1 more source
Clinical, Cosmetic and Investigational Dermatology, 2021 Guohong Hu, Xiansheng Zhou Dermatology Hospital of Jiangxi Province, Nanchang, 330001, Jiangxi, People’s Republic of ChinaCorrespondence: Guohong HuDermatology Hospital of Jiangxi Province, No.
Hu G, Zhou X
doaj
Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity
Advanced Science, EarlyView.Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang +11 more
wiley +1 more source
The Th17/Treg Cell Balance: A Gut Microbiota-Modulated Story
Microorganisms, 2019 The intestinal tract of vertebrates is normally colonized with a remarkable number of commensal microorganisms that are collectively referred to as gut microbiota.
Hongyu Cheng +3 more
doaj +1 more source
CD69 Association with Jak3/Stat5 Proteins Regulates Th17 Cell Differentiation
, 2010 This work was supported by grant SAF2008-02719 from the Spanish Ministry of Science and Innovation to P.M.; grant PI06/0937 from ISCIII-MSC to M.G.; and grants SAF2008-02635 from the Spanish Ministry of Science and Innovation, RECAVA [RD06/0014-0030 ...
Martín, Pilar +15 more
core +1 more source
Advanced Science, EarlyView.Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang +10 more
wiley +1 more source