Results 71 to 80 of about 169,698 (304)
Immunological Medicine, 2022 Th17 cells are implicated in the pathogenesis of several autoimmune diseases. During the inflammation, Th17 cells exposed to IL-12 can shift towards the Th1 phenotype. These shifted cells are defined as ‘non-classic Th1 cells’.
Bo-Young Shin +5 more
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Медицинская иммунология, 2023 Psoriasis is a chronic inflammatory skin disease characterized by increased proliferation of epidermal cells, impaired keratinization and an inflammatory reaction in dermis caused by activation of T lymphocytes and synthesis of pro-inflammatory cytokines.
D. G. Kuptsova +8 more
doaj +1 more source
The Th17 pathway in cystic fibrosis lung disease
, 2011 In contrast to the neutrophilic inflammation found in the airway lumen, lymphocytes predominate in the airway wall of Cystic fibrosis (CF) patients.
Davies, Jane +13 more
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The Dynamics of Treg/Th17 and the Imbalance of Treg/Th17 in Clonorchis sinensis-Infected Mice. [PDF]
, 2015 Clonorchiasis, caused by the liver fluke Clonorchis sinensis, is a chronic parasitic infection regulated by T cell subsets. An imbalance of CD4+CD25+ Foxp3+regulatory T (Treg) and interleukin (IL)-17-secreting T cells (Th17) may control inflammation and ...
Chao Yan (150844) +35 more
core +1 more source
Investigation of Complement Activation and Cytokine Signatures in AQP4+ NMOSD, MOGAD, and MS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Aquaporin‐4‐IgG seropositive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), and multiple sclerosis (MS) are pathophysiologically distinct neuroinflammatory disorders. Complement activation is a major mechanism of injury in AQP4+ NMOSD, whereas its role in
Angeliki G. Filippatou +23 more
wiley +1 more source
Sox5 and Th17 cell differentiation
Oncotarget, 2015 Sox (SRY-related high-mobility-group (HMG)-box) transcription factors, which are comprised of 20 genes containing a conserved HMG DNA-binding domain, are divided into 8 groups (from A to H) according to structural homologies [reviewed in 1–2]. SoxC group, which is composed of Sox4, Sox11, and Sox12, has a HMG box domain and a transactivation domain and
Akira, Suto +2 more
openaire +2 more sources
Th17 polarization of memory Th cells in early arthritis: the vasoactive intestinal peptide effect
, 2015 Several studies in humans indicate the implication of Th17 cells in RA. Therapies targeting their pathogenicity, as well as their plasticity to the Th17/1 phenotype, could ameliorate the progression of the pathology.
Mellado, Mario +9 more
core +1 more source
From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis
Arthritis Care &Research, EarlyView.Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss +9 more
wiley +1 more source
Changes in Bone Metabolism and Structure in Primary Hyperparathyroidism
Acta Medica Bulgarica, 2020 Parathyroid hormone (PTH) is a key regulator of bone turnover. Depending on the duration of action, the hormone causes catabolic and anabolic effects by binding with specific receptors (PTHR1) in the bone.
Yankova I., Shinkov A., Kovatcheva R.
doaj +1 more source
The transient nature of the Th17 phenotype [PDF]
European Journal of Immunology, 2010 AbstractCD4+ Th lymphocytes represent a heterogeneous population of cells that play an essential role in adaptive immunity. In addition to type 1 (Th1) and type 2 (Th2) cells, a third subset of CD4+ Th effector cells has recently been discovered, named type 17 (Th17) because of its unique ability to produce interleukin (IL)‐17.
ANNUNZIATO, FRANCESCO, ROMAGNANI, SERGIO
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