Results 71 to 80 of about 187,124 (359)

Transcription factor RORα enforces stability of the Th17 cell effector program by binding to a Rorc cis-regulatory element

Immunity, 2022
Summary: T helper 17 (Th17) cells regulate mucosal barrier defenses, but also promote multiple autoinflammatory diseases. Although many molecular determinants of Th17 cell differentiation have been elucidated, the transcriptional programs that sustain ...
J. Hall, Maria Pokrovskii, Lina Kroehling, B. Kim, S. Kim, Lin Wu, June-Yong Lee, D. Littman   +7 more
semanticscholar   +1 more source

Negative regulation of Th17 responses [PDF]

Seminars in Immunology, 2007
The discovery of the Th17 lineage of T helper cells and the realization that this subset was implicated in the pathogenesis of a variety of inflammatory conditions has lead to an intense effort devoted to identifying the cytokines and transcription factors that promote their development.
J S, Stumhofer, J, Silver, C A, Hunter
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Gallic Acid Ameliorates Atopic Dermatitis-Like Skin Inflammation Through Immune Regulation in a Mouse Model

Clinical, Cosmetic and Investigational Dermatology, 2021
Guohong Hu, Xiansheng Zhou Dermatology Hospital of Jiangxi Province, Nanchang, 330001, Jiangxi, People’s Republic of ChinaCorrespondence: Guohong HuDermatology Hospital of Jiangxi Province, No.
Hu G, Zhou X
doaj  

Phenotypic and functional features of human Th17 cells

Journal of Experimental Medicine, 2007
T helper (Th) 17 cells represent a novel subset of CD4+ T cells that are protective against extracellular microbes, but are responsible for autoimmune disorders in mice. However, their properties in humans are only partially known.
F. Annunziato, L. Cosmi, V. Santarlasci, L. Maggi, F. Liotta, B. Mazzinghi, E. Parente, L. Filì, S. Ferri, Francesca Frosali, F. Giudici, P. Romagnani, P. Parronchi, F. Tonelli, E. Maggi, S. Romagnani   +15 more
semanticscholar   +1 more source

The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease

Journal of Immunological Research, 2020
Inflammatory bowel disease (IBD) is a chronic, inflammatory, and autoimmune disorder. The pathogenesis of IBD is not yet clear. Studies have shown that the imbalance between T helper 17 (Th17) and regulatory T (Treg) cells, which differentiate from CD4 ...
Jun-bin Yan, Minmin Luo, Zhi-Yun Chen, Beihui He   +3 more
semanticscholar   +1 more source

Stigmasterol Restores the Balance of Treg/Th17 Cells by Activating the Butyrate-PPARγ Axis in Colitis

Frontiers in Immunology, 2021
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with gut microbiota disequilibrium and regulatory T (Treg)/T helper 17 (Th17) immune imbalance. Stigmasterol, a plant-derived sterol, has shown anti-inflammatory effects. Our study aimed
Shuting Wen, Long He, Zhuotai Zhong, Runyuan Zhao, Senhui Weng, Hong Mi, Fengbin Liu   +6 more
semanticscholar   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

The Th17/Treg Cell Balance: A Gut Microbiota-Modulated Story

Microorganisms, 2019
The intestinal tract of vertebrates is normally colonized with a remarkable number of commensal microorganisms that are collectively referred to as gut microbiota.
Hongyu Cheng, Xiong Guan, Dekun Chen, Wentao Ma   +3 more
doaj   +1 more source

Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice

Immunity, 2019
Summary Microbiota are thought to influence the development and progression of inflammatory bowel disease (IBD), but determining generalizable effects of microbiota on IBD etiology requires larger‐scale functional analyses.
G. Britton, Eduardo J. Contijoch, Ilaria Mogno, Olivia H. Vennaro, Sean R. Llewellyn, Ruby Ng, Zhihua Li, A. Mortha, M. Merad, Anuk M. Das, D. Gevers, D. McGovern, Namita Singh, J. Braun, J. Jacobs, J. Clemente, A. Grinspan, B. Sands, J. Colombel, M. Dubinsky, J. Faith   +20 more
semanticscholar   +1 more source