Results 51 to 60 of about 169,698 (304)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Role and plasticity of Th1 and Th17 responses in immunity to Staphylococcus aureus

Human Vaccines & Immunotherapeutics, 2019
The human commensal Staphylococcus aureus (SA) is a leading cause of skin/soft tissue and surgical-site infections, and bacteremia. Functional antibodies and T-cell-mediated immunity, particularly Th1/Th17 responses, are thought to mediate protection ...
Alessandra Ferraro, Sofia M. Buonocore, Philippe Auquier, Isabelle Nicolas, Hugues Wallemacq, Dominique Boutriau, Robbert G. van der Most   +6 more
doaj   +1 more source

Th17 cells in human disease [PDF]

Immunological Reviews, 2008
Summary:Our understanding of the role of T cells in human disease is undergoing revision as a result of the discovery of T‐helper 17 (Th17) cells, a unique CD4+T‐cell subset characterized by production of interleukin‐17 (IL‐17). IL‐17 is a highly inflammatory cytokine with robust effects on stromal cells in many tissues.
Tesmer, Laura A., Lundy, Steven K., Sarkar, Sujata, Fox, David A.   +3 more
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Pharmacological Inhibition of PPAR_y Boosts HIV Reactivation and Th17 Effector Functions, while Preventing Progeny Virion Release and de novo Infection

Pathogens and Immunity, 2020
The frequency and functions of Th17-polarized CCR6+RORyt+CD4+ T cells are rapidly compromised upon HIV infection and are not restored with long-term viral suppressive antiretroviral therapy (ART).
Delphine Planas, Augustine Fert, Yuwei Zhang, Jean-Philippe Goulet, Jonathan Richard, Andrés Finzi, Maria Julia Ruiz, Laurence Raymond Marchand, Debashree Chatterjee, Huicheng Chen, Tomas Raul Wiche Salinas, Annie Gosselin, Eric A. Cohen, Jean-Pierre Routy, Nicolas Chomont, Petronela Ancuta   +15 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

More stories on Th17 cells [PDF]

Cell Research, 2009
For more than two decades, immunologists have been using the so-called Th1/Th2 paradigm to explain most of the phenomena related to adaptive immunity. The Th1/Th2 paradigm implied the existence of two different, mutually regulated, CD4(+) T helper subsets: Th1 cells, driving cell-mediated immune responses involved in tissue damage and fighting ...
Alexandre S, Basso, Hilde, Cheroutre, Daniel, Mucida   +2 more
openaire   +2 more sources

Suppression of Th17-polarized airway inflammation by rapamycin [PDF]

, 2017
Because Th17-polarized airway inflammation correlates with poor control in bronchial asthma and is a feature of numerous other difficult-to-treat inflammatory lung diseases, new therapeutic approaches for this type of airway inflammation are necessary ...
Matthias Lochner, Feller, Felix, Adan Chari Jirmo, Oana Joean, Melanie Albrecht, Albrecht, Melanie, Lochner, Matthias, Anna-Maria Dittrich, Jirmo, Adan Chari, Hueber, Anja, Felix Feller, Joean, Oana, Dittrich, Anna-Maria, Anja Hueber   +13 more
core   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Th1 and Th17 cells [PDF]

Annals of the New York Academy of Sciences, 2010
Autoreactive effector CD4+ T cells have been associated with the pathogenesis of autoimmune disorders. Early studies implicated the interferon (IFN)‐γ‐producing T helper (Th)1 subset of CD4+ cells as the causal agents in the pathogenesis of autoimmunity. However, further studies have suggested a more complex story. In models thought to be driven by Th1
Jesse M, Damsker, Anna M, Hansen, Rachel R, Caspi   +2 more
openaire   +2 more sources