Results 31 to 40 of about 169,698 (304)
IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo [PDF]
, 2014 IL-6 plays a pivotal role in favoring T-cell commitment toward a Th17 cell rather than Treg-cell phenotype, as established through in vitro model systems.
Maizels, Rick M. +5 more
core +1 more source
Chinese Journal of Lung Cancer, 2019 Chronic obstructive pulmonary disease (COPD) and lung cancer are global high incidence and high mortality diseases, which seriously increase the socio-economic burden. Smoke exposure, genetic susceptibility and chronic inflammation are common susceptible
Jinhua ZHOU, Wei WANG, Ruijuan LIU
doaj +1 more source
Effects of glycodelin on CCR6+ cell subpopulations of Th17-polarized helper T cells
Медицинская иммунология, 2023 Glycodelins, the glycosylated proteins of reproductive tract are characterized by immunomodulatory functions, are of interest because of their role in the development of immune tolerance.
V. P. Timganova +6 more
doaj +1 more source
Differential regulation of interleukin-17 and interferon-y production in inflammatory bowel disease [PDF]
, 2010 PhDBackground and Aims. Interleukin (IL)-17 is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear. Methods.
Rovedatti, Laura
core +2 more sources
Autoimmunity, 2017 Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease.
Weshely Kujur +6 more
doaj +1 more source
Gut Microbes, 2020 Dysbiotic microbiota contributes to the pathogenesis of Crohn’s disease (CD) by regulating the immune system. Although pro-inflammatory microbes are probably enriched in the small intestinal (SI) mucosa, most studies have focused on fecal microbiota ...
Manabu Nagayama +20 more
doaj +1 more source
IRAK4 Kinase Activity Is Required for Th17 Differentiation and Th17-Mediated Disease [PDF]
The Journal of Immunology, 2009 Abstract Both IL-23- and IL-1-mediated signaling pathways play important roles in Th17 cell differentiation, cytokine production, and autoimmune diseases. The IL-1R-associated kinase 4 (IRAK4) is critical for IL-1/TLR signaling. We show here that inactivation of IRAK4 kinase in mice (IRAK4 KI) results in significant resistance to ...
Kirk A, Staschke +13 more
openaire +2 more sources
Th17/Treg Imbalance and Atherosclerosis [PDF]
Disease Markers, 2020 Atherosclerosis is nowadays recognized as a chronic inflammatory disease of large arteries. In recent years, cellular and molecular biology studies on atherosclerosis confirmed that the occurrence and development are related to inflammation and autoimmunity.
Xin He, Bo Liang, Ning Gu
openaire +2 more sources
Gut Microbiota-Derived Indole-3-Acetaldehyde Contributes to the Disease-Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis. [PDF]
Adv Sci (Weinh)Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Han X +11 more
europepmc +2 more sources
Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract [PDF]
, 2010 Includes bibliographical references (leaves 85-103).T helper (Th) 17 cells have recently been implicated in regulating gut mucosal immunity during HIV infection by sustaining gut mucosal barrier integrity, although they do not respond to HIV directly ...
Salkinder, Amy Leia
core +1 more source