Results 31 to 40 of about 187,124 (359)
Human Th17 cells: Are they different from murine Th17 cells? [PDF]
European Journal of Immunology, 2009 AbstractType 17 Th (Th17) cells have been identified as a distinct population of CD4+ effector T cells different from Th1 and Th2 cells. While the pre‐eminent cytokine of Th1 cells is IFN‐γ and that of Th2 cells is IL‐4, the distinctive cytokine of Th17 cells is IL‐17A.
ANNUNZIATO, FRANCESCO +4 more
openaire +3 more sources
The Journal of Reproduction and Development, 2021 Immune imbalance of Treg/Th17 cells may contribute to recurrent implantation failure (RIF) during in vitro fertilization and embryo transfer (IVF-ET). In this study, we sought to determine the effect of intrauterine administration of mouse PBMCs prior to
Lei FAN +6 more
doaj +1 more source
TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 2020 COVID-19 emerges as a pandemic disease with high mortality. Development of effective prevention and treatment is an urgent need. We reviewed TH17 responses in patients with SARS-CoV-2 and proposed an FDA approved JAK2 inhibitor Fedratinib for reducing ...
Dandan Wu, Xuexian O. Yang
semanticscholar +1 more source
Lactate induces metabolic and epigenetic reprogramming of pro‐inflammatory Th17 cells
EMBO Reports, 2022 Increased lactate levels in the tissue microenvironment are a well‐known feature of chronic inflammation. However, the role of lactate in regulating T cell function remains controversial.
Aleksandra Lopez Krol +14 more
semanticscholar +1 more source
Allergology International, 2008 The identification of novel helper T (Th) cell subsets, i.e., IL-17-producing Th cells (Th17 cells) and regulatory T cells (Treg cells), provided new insight into our understanding of the molecular mechanisms involved in the development of infectious and autoimmune diseases as well as immune responses, and thus led to revision of the classic Th1/Th2 ...
Oboki, Keisuke +3 more
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The Alterations in and the Role of the Th17/Treg Balance in Metabolic Diseases
Frontiers in Immunology, 2021 Chronic inflammation plays an important role in the development of metabolic diseases. These include obesity, type 2 diabetes mellitus, and metabolic dysfunction-associated fatty liver disease.
Siwen Zhang +6 more
semanticscholar +1 more source
Frontiers in Immunology, 2020 During pregnancy, various immune effectors and molecules participating in the immune-microenvironment establish specific maternal tolerance toward the semi-allogeneic fetus.
Wen-juan Wang +3 more
semanticscholar +1 more source
Медицинская иммунология, 2020 We aimed for assessing effects of immunocytotherapy upon the subpopulations of CD4+CD25highFoxP3+ cellswithnaturalregulatoryactivityandactivatedTh17cellswiththeCD4+CD25highRORγt+ phenotype, as well as in vitro production of cytokines in mitogen ...
L. V. Krechetova +5 more
doaj +1 more source
Induction of intestinal Th17 cells by segmented filamentous bacteria
Cell, 2009 SUMMARY The gastrointestinal tract of mammals is inhabited by hundreds of distinct species of commensal microorganisms that exist in a mutualistic relationship with the host. How commensal microbiota influence the host immune system is poorly understood.
I. Ivanov +16 more
semanticscholar +1 more source
Arthritis Research & Therapy, 2008 The discovery in mice of a new lineage of CD4+ effector T helper (Th) cells that selectively produce IL-17 has provided exciting new insights into immune regulation, host defence, and the pathogenesis of autoimmune and other chronic inflammatory disorders.
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