Results 41 to 50 of about 187,124 (359)
Propionibacterium acnes Promotes Th17 and Th17/Th1 Responses in Acne Patients [PDF]
Journal of Investigative Dermatology, 2015 Propionibacterium acnes is a Gram-positive commensal bacterium thought to be involved in the pathogenesis of acne vulgaris. Although the ability of P. acnes in the initiation of pro-inflammatory responses is well documented, little is known about adaptive immune responses to this bacterium.
Kistowska Magdalena +7 more
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Pathogens and Immunity, 2020 The frequency and functions of Th17-polarized CCR6+RORyt+CD4+ T cells are rapidly compromised upon HIV infection and are not restored with long-term viral suppressive antiretroviral therapy (ART).
Delphine Planas +15 more
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Th17 cytokines and arthritis [PDF]
Seminars in Immunopathology, 2010 Th17 cells are implicated in human autoimmune diseases, such as rheumatoid arthritis (RA), although it has not been established whether this persistent destructive arthritis is driven by Th1 and/or Th17 cells. Interleukin-17A (IL-17A) contributes to the pathogenesis of arthritis as has been shown in several experimental arthritis models.
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Identification of Th1-polarized Th17 cells: solving the problem
Медицинская иммунология, 2023 Helper T cells producing IL-17 (Th17) have high plasticity: restimulation of lymphocytes in an inflammatory environment can induce their transformation into cells with another phenotype, and a shift towards Th1 is the most common.
E. M. Kuklina, N. S. Glebezdina
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Bile acid metabolites control Th17 and Treg cell differentiation
Nature, 2018 Bile acids are abundant in the mammalian gut, where they undergo bacteria-mediated transformation to generate a large pool of bioactive molecules. Although bile acids are known to affect host metabolism, cancer progression and innate immunity, it is ...
Saiyu Hang +19 more
semanticscholar +1 more source
Human gut bacterial metabolism drives Th17 activation and colitis
Cell Host and Microbe, 2021 SUMMARY Bacterial activation of T helper 17 (Th17) cells exacerbates mouse models of autoimmunity, but how human-associated bacteria impact Th17-driven disease remains elusive.
Margaret Alexander +9 more
semanticscholar +1 more source
A rush to judgment on Th17 [PDF]
The Journal of Experimental Medicine, 2008 Some immunologists have characterized T helper (Th)17 T cells as the master mediators of tissue damage in a variety of pathological conditions. New data now demonstrate that Th1 and Th17 T cells are independently capable of inducing disease in two established models of autoimmunity.
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Chinese Journal of Lung Cancer, 2019 Chronic obstructive pulmonary disease (COPD) and lung cancer are global high incidence and high mortality diseases, which seriously increase the socio-economic burden. Smoke exposure, genetic susceptibility and chronic inflammation are common susceptible
Jinhua ZHOU, Wei WANG, Ruijuan LIU
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Медицинская иммунология, 2023 Psoriasis is a chronic inflammatory skin disease characterized by increased proliferation of epidermal cells, impaired keratinization and an inflammatory reaction in dermis caused by activation of T lymphocytes and synthesis of pro-inflammatory cytokines.
D. G. Kuptsova +8 more
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Autoimmunity, 2017 Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease.
Weshely Kujur +6 more
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