Results 21 to 30 of about 187,124 (359)
Human gut bacteria produce TH17-modulating bile acid metabolites
Nature, 2022 The microbiota modulates gut immune homeostasis. Bacteria influence the development and function of host immune cells, including T helper cells expressing interleukin-17A (TH17 cells). We previously reported that the bile acid metabolite 3-oxolithocholic
Donggi Paik +20 more
semanticscholar +1 more source
Regulation of T cell differentiation by the AP-1 transcription factor JunB
Immunological Medicine, 2021 JunB, a component of the activator protein-1 (AP-1) transcription factor, is known to exhibit an important role in bone formation and bone marrow cell proliferation. During T helper type 2 (Th2) cell differentiation, JunB contributes to the regulation of
Takaharu Katagiri +3 more
doaj +1 more source
Metabolic Modeling of Single Th17 Cells Reveals Regulators of Autoimmunity
Cell, 2021 Summary Metabolism is a major regulator of immune cell function, but it remains difficult to study the metabolic status of individual cells. Here, we present Compass, an algorithm to characterize cellular metabolic states based on single-cell RNA-Seq and
Allon Wagner +25 more
semanticscholar +1 more source
The role of Th17 cells in inflammatory bowel disease and the research progress
Frontiers in Immunology, 2023 Th17 cells play an important role in the abnormal immune response in inflammatory bowel disease (IBD) and are involved in the development and progression of inflammation and fibrosis. An increasing amount of data has shown that gut microbes are important
Lu Chen +5 more
semanticscholar +1 more source
Contribution of B-lymphocytes to the production of Interleukin-17 in multiple sclerosis
Неврология, нейропсихиатрия, психосоматика, 2023 The study of pathogenic systems involved in multiple sclerosis (MS) is essential for the development of new therapies.Objective: to determine the contribution of B-lymphocytes to the production of IL-17 in MS with an assessment of the ability of B-cells ...
N. V. Sursyakova +4 more
doaj +1 more source
Медицинская иммунология, 2023 The hormone melatonin is involved in regulation of functioning of almost all organs and systems of the organism. In the immune system, T lymphocytes are an important target of melatonin: they express specific melatonin receptors with different affinities
N. S. Glebezdina +2 more
doaj +1 more source
Th17/Treg Imbalance: Implications in Lung Inflammatory Diseases
International Journal of Molecular Sciences, 2023 Regulatory T cells (Tregs) and T helper 17 cells (Th17) are two CD4+ T cell subsets with antagonist effects. Th17 cells promote inflammation, whereas Tregs are crucial in maintaining immune homeostasis.
Rony Thomas, Sai Qiao, Xi Yang
semanticscholar +1 more source
Analysis of regulatory T lymphocytes in fungal infections
Медицинская иммунология, 2021 Morbidity and mortality rates in invasive mycoses determine the need to improve methods for their timely diagnosis by assessment the patients’ immune status.
S. V. Popov +2 more
doaj +1 more source
Science Advances, 2023 Dysregulation of CD4+ T cell differentiation is linked to autoimmune diseases. Metabolic reprogramming from oxidative phosphorylation to glycolysis and accumulation of lactate are involved in this process.
Wei Fan +11 more
semanticscholar +1 more source
Mìžnarodnij Endokrinologìčnij Žurnal, 2020 The review deals with the role of innate and adaptive, local and systemic immunity, cellular and humoral factors in the pathogenesis of autoimmune thyroid diseases (AITD).
T.F. Zakharchenko, V.I. Kravchenko
doaj +1 more source