Results 11 to 20 of about 187,124 (359)

Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity

Cell, 2021
Summary While intestinal Th17 cells are critical for maintaining tissue homeostasis, recent studies have implicated their roles in the development of extra-intestinal autoimmune diseases including multiple sclerosis.
Alexandra Schnell, Linglin Huang, Meromit Singer   +2 more
exaly   +2 more sources

Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans

Cell, 2019
Th17 cells provide protection at barrier tissues but may also contribute to immune pathology. The relevance and induction mechanisms of pathologic Th17 responses in humans are poorly understood.
Petra Bacher, Matthew G Blango, Patience Eschenhagen   +2 more
exaly   +2 more sources

The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24

Immunity, 2020
Dysregulated Th17 cell responses underlie multiple inflammatory and autoimmune diseases, including autoimmune uveitis and its animal model, EAU. However, clinical trials targeting IL-17A in uveitis were not successful.
Wai Po Chong, Mary J Mattapallil, Kumarkrishna Raychaudhuri   +2 more
exaly   +2 more sources

The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation

Immunity, 2021
Summary Th17 cells are known to exert both pathogenic and non-pathogenic functions. While the cytokine TGF-β1 is instrumental to Th17 cell differentiation, it is dispensible for the generation of pathogenic-Th17 cells.
Bing Wu, Song Zhang, Zengli Guo
exaly   +2 more sources

Concomitant Expression of IL-6 and TGF-β Cytokines and their Receptors in Peripheral Blood of Patients with Multiple Sclerosis: The Effects of INFβ Drugs [PDF]

Iranian Journal of Immunology, 2022
Background: Concomitant signals from IL-6 and TGF-β have a central role in the Th17 cells development and differentiation, and these cells are the main promoters of demyelinating inflammation in the central nervous system (CNS) resulting in multiple ...
Parisa Maleki, Bahareh Abd-Nikfarjam, Azam Jamshidian   +2 more
doaj   +1 more source

Interleukin-27 Suppresses T Helper-17 Inflammation in Allergic Rhinitis [PDF]

Iranian Journal of Immunology, 2020
Background: T helper 17 (Th17) cells and the related cytokines, interleukin (IL)- 17 and IL-23, were proved to play pivotal roles during the development of allergic rhinitis (AR).
Hong Ouyang, Jie Cheng, Jingdong Du, Huiyun Gan, Zheng Lu   +4 more
doaj   +1 more source

Lipoprotein(a) concentration and the blood content of INFγ-producing T-helpers 17 (Th17/1) in males with premature coronary artery disease

Российский кардиологический журнал, 2022
Aim. To analyze the relationship of blood lipid profile parameters, including the level of lipoprotein(a) (Lp(a)), and the content of circulating CD4+ T-lymphocytes with premature coronary artery disease (CAD).Material and methods.
A. Yu. Filatova, O. I. Afanasieva, T. I. Arefieva, E. A. Klesareva, A. V. Tyurina, M. V. Ezhov, S. N. Pokrovsky   +6 more
doaj   +1 more source

Intricacies of TGF-β signaling in Treg and Th17 cell biology

Cellular & Molecular Immunology, 2023
Balanced immunity is pivotal for health and homeostasis. CD4^+ helper T (Th) cells are central to the balance between immune tolerance and immune rejection. Th cells adopt distinct functions to maintain tolerance and clear pathogens.
Junying Wang, Xingqi Zhao, Y. Wan
semanticscholar   +1 more source

Lactobacillus rhamnosus GG ameliorates osteoporosis in ovariectomized rats by regulating the Th17/Treg balance and gut microbiota structure

Gut microbes, 2023
Background With increasing knowledge about the gut – bone axis, more studies for treatments based on the regulation of postmenopausal osteoporosis by gut microbes are being conducted.
Mengyu Guo, Huanjin Liu, Yin-Ping Yu, Xingyu Zhu, Hui Xie, Chenxu Wei, Chunmei Mei, Yun Shi, Nong Zhou, Kunming Qin, Weidong Li   +10 more
semanticscholar   +1 more source

Informative value of laboratory markers in assessing the stage of liver fibrosis in children with type 1 autoimmune hepatitis

Аллергология и Иммунология в Педиатрии, 2023
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O. V. Kurbatova, G. B. Movsisyan, S. V. Petrichuk, D. V. Parakhina, D. S. Demyanov, D. G. Kuptsova, T. V. Radygina, E. L. Semikina, A. S. Potapov, E. V. Freidlin   +9 more
doaj   +1 more source