Results 11 to 20 of about 169,698 (304)

Propionibacterium acnes Promotes Th17 and Th17/Th1 Responses in Acne Patients [PDF]

Journal of Investigative Dermatology, 2015
Propionibacterium acnes is a Gram-positive commensal bacterium thought to be involved in the pathogenesis of acne vulgaris. Although the ability of P. acnes in the initiation of pro-inflammatory responses is well documented, little is known about adaptive immune responses to this bacterium.
Kistowska Magdalena, Meier Barbara, Proust Tatiana, Feldmeyer Laurence, Cozzio Antonio, Kuendig Thomas, Contassot Emmanuel, French Lars E.   +7 more
openaire   +7 more sources

Th17 profile in COPD exacerbations [PDF]

International Journal of Chronic Obstructive Pulmonary Disease, 2017
COPD is characterized by an ongoing inflammatory process of the airways that leads to obstruction or limitation of airflow. It is mainly associated with exposure to cigarette smoke. In addition, it is considered, at present, a serious public health problem, ranking fourth in mortality worldwide.
Marco Ponce-Gallegos, Alejandra Ramírez-Venegas, Ramcés Falfán-Valencia   +2 more
openaire   +6 more sources

Markers of Th1 polarized Th17 cells (literature review) [PDF]

Acta Biomedica Scientifica, 2023
T helpers (Th) producing IL-17 (Th17) have high plasticity and under the influence of external conditions are able to redifferentiate into cells with a different phenotype, primarily in Th1-lymphocytes, forming a population that combines the ...
E. M. Kuklina, N. S. Glebezdina
doaj   +2 more sources

Identification of Th1-polarized Th17 cells: solving the problem [PDF]

Медицинская иммунология, 2023
Helper T cells producing IL-17 (Th17) have high plasticity: restimulation of lymphocytes in an inflammatory environment can induce their transformation into cells with another phenotype, and a shift towards Th1 is the most common.
E. M. Kuklina, N. S. Glebezdina
doaj   +2 more sources

Human Th17 cells: Are they different from murine Th17 cells? [PDF]

European Journal of Immunology, 2009
AbstractType 17 Th (Th17) cells have been identified as a distinct population of CD4+ effector T cells different from Th1 and Th2 cells. While the pre‐eminent cytokine of Th1 cells is IFN‐γ and that of Th2 cells is IL‐4, the distinctive cytokine of Th17 cells is IL‐17A.
ANNUNZIATO, FRANCESCO, COSMI, LORENZO, LIOTTA, FRANCESCO, MAGGI, ENRICO, ROMAGNANI, SERGIO   +4 more
openaire   +3 more sources

HECTD1 Directs HIF-1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis. [PDF]

Adv Sci (Weinh)
HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Xu S, Han Q, Wang F, Zhang Y, Feng H, Liu K, Luo FX, Yuan F, Zhao X, Yu X, Huang H, Zou Q, Zhao R.   +12 more
europepmc   +2 more sources

Th17 and Allergy

Allergology International, 2008
The identification of novel helper T (Th) cell subsets, i.e., IL-17-producing Th cells (Th17 cells) and regulatory T cells (Treg cells), provided new insight into our understanding of the molecular mechanisms involved in the development of infectious and autoimmune diseases as well as immune responses, and thus led to revision of the classic Th1/Th2 ...
Oboki, Keisuke, Ohno, Tatsukuni, Saito, Hirohisa, Nakae, Susumu   +3 more
openaire   +2 more sources

The Endogenous Th17 Response in NO2-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer [PDF]

, 2013
Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease.
Suratt, Benjamin T., Weiss Daniel J., Laura Hoyt, Daggett, Rebecca, Alcorn John F., Poynter, ME, Daggett, R, Daggett Rebecca, Martin, Rebecca A., Lundblad Lennart K. A., Martin, RA, Daniel J. Weiss (460686), Ather Jennifer L., Lennart K. A. Lundblad (49082), Jennifer L. Ather (460682), Rebecca Daggett (460683), Alcorn, John F., Poynter, Matthew E., Hoyt Laura, Laura Hoyt (460684), John F. Alcorn (298001), Hoyt, L, Martin Rebecca A., Lennart K A Lundblad, Rebecca A Martin, Lundblad, Lennart K. A., Rebecca A. Martin (435571), Hoyt, Laura, Weiss, Daniel J., Poynter Matthew E., Rebecca Daggett, John F Alcorn, Alcorn, JF, Benjamin T Suratt, Suratt, BT, Ather, Jennifer L., Daniel J Weiss, Matthew E. Poynter (435575), Weiss, DJ, Lundblad, LKA, Jennifer L Ather, Benjamin T. Suratt (460685), Ather, JL, Chu, Hong Wei, Matthew E Poynter, Suratt Benjamin T.   +45 more
core   +2 more sources

Th17-cells in comparison of severity grades of dogs suffering from IVDH and the healthy control group.

, 2021
Absolute number of stimulated Th17-cells/μl in canine blood with different severity of neurological signs. Green boxplot: Healthy control group; Blue boxplots: IVDH group measured preoperatively, classified by the grading system (grade 1–5) of Sharp and ...
Regina Carlson (388166), Annika Kämpe (11507012), Karl Rohn (555695), Andrea Tipold (192569), Anna Knebel (6757913)   +4 more
core   +1 more source

The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans [PDF]

, 2011
IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ...
Di Meglio, P, Chung-Ching Chu, Francesca Capon, Di Meglio, Paola, Napolitano, Luca, Napolitano, L, Ketty Peris, Di Cesare, Antonella, Villanova, Federica, Villanova, F, Richard C. Trembath, Isabella Tosi, Paola Di Meglio, Richard C Trembath, Laggner, Ute, Chu, Chung-Ching, Chu, CC, Capon, Francesca, Federica Villanova, Frank O Nestle, Nestle, FO, Peris, K, Nestle, Frank O., Antonella Di Cesare, Peris, Ketty, Trembath, RC, Laggner, U, Tosi, Isabella, Luca Napolitano, Capon, F, Frank O. Nestle, Ute Laggner, Trembath, Richard C., Di Cesare, A, Tosi, I, Chu Chung-Ching, Peris Ketty, Laggner Ute, Napolitano Luca, Di Meglio Paola, Nestle Frank O., Trembath Richard C., Capon Francesca, Di Cesare Antonella, Villanova Federica, Tosi Isabella   +45 more
core   +2 more sources