The emerging role of Th1 cells in atherosclerosis and its implications for therapy [PDF]
Frontiers in Immunology, 2023 Atherosclerosis is a chronic progressive inflammatory disease of the large and medium-sized artery walls. The molecular mechanisms regulating the onset and progression of atherosclerosis remain unclear.
Jiaojiao Chen +7 more
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Interferon-γ secreted by recruited Th1 cells in peritoneal cavity inhibits the formation of malignant ascites [PDF]
Cell Death Discovery, 2023 Type 1 T helper (Th1) cells generate an efficient antitumor immune response in multiple malignancies. The functions of Th1 cells in malignant ascites (MA) have not been elucidated.
Chang Liu +7 more
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Delayed Activation Kinetics of Th2- and Th17 Cells Compared to Th1 Cells
Cells, 2017 During immune responses, different classes of T cells arise: Th1, Th2, and Th17. Mobilizing the right class plays a critical role in successful host defense and therefore defining the ratios of Th1/Th2/Th17 cells within the antigen-specific T cell ...
Andrea Duechting +3 more
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Functional characteristics of Th1, Th17, and ex-Th17 cells in EAE revealed by intravital two-photon microscopy [PDF]
Journal of Neuroinflammation, 2020 Background T helper (Th) 17 cells are a highly plastic subset of T cells, which in the context of neuroinflammation, are able to acquire pathogenic features originally attributed to Th1 cells (resulting in so called ex-Th17 cells).
Julia Loos +7 more
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A molecular signature for IL-10–producing Th1 cells in protozoan parasitic diseases [PDF]
JCI Insight, 2023 Control of visceral leishmaniasis (VL) depends on proinflammatory Th1 cells that activate infected tissue macrophages to kill resident intracellular parasites.
Chelsea L. Edwards +17 more
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Id3 expression identifies CD4<sup>+</sup> memory Th1 cells. [PDF]
Proc Natl Acad Sci U S A, 2022 Memory CD4 + T cells play a pivotal role in mediating long-term protective immunity, positioning them as an important target in vaccine development. However, multiple functionally distinct helper CD4 + T-cell subsets can arise in response to a single invading pathogen, complicating the ...
Shaw LA +5 more
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Natural Th1 cells: escape from neglect
Oncotarget, 2015 A novel idea that there is an alternative pathway for intrathymic generation of mature CD4+ T cells came from the observation that immature thymocytes were also able to express MHC class II on their cell surfaces during fetal thymic development [1]. This
S. Park
semanticscholar +3 more sources
Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.
PLoS Pathogens, 2015 Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain elusive. While the importance of cellular immunity has been shown in mice, T cell responses in humans have not been characterised.
Aisling F Brown +18 more
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Enhanced Rg3 negatively regulates Th1 cell responses
Journal of Ginseng Research, 2019 Background: Korean Red Ginseng (KRG; Panax ginseng Meyer) is a widely used medicinal herb known to exert various immune modulatory functions. KRG and one of its purified components, ginsenoside Rg3, are known to possess anti-inflammatory activities.
Minkyoung Cho +3 more
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Effects of the Antidiabetic Drugs Evogliptin and Sitagliptin on the Immune Function of CD26/DPP4 in Th1 Cells. [PDF]
Biomol Ther (Seoul), 2021 Yoon H, Sung JH, Song MJ.
europepmc +3 more sources