Interferon-γ secreted by recruited Th1 cells in peritoneal cavity inhibits the formation of malignant ascites [PDF]
Cell Death Discovery, 2023 Type 1 T helper (Th1) cells generate an efficient antitumor immune response in multiple malignancies. The functions of Th1 cells in malignant ascites (MA) have not been elucidated.
Chang Liu +7 more
doaj +2 more sources
Frontiers in Immunology, 2022 T helper 1 cells (Th1 cells) and T helper 17 cells (Th17 cells) play pivotal roles in the pathogenesis of various autoimmune diseases, including psoriasis and inflammatory bowel disease (IBD).
Jiyoon Park +7 more
doaj +1 more source
Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation. [PDF]
PLoS Biology, 2013 Differentiated T helper (Th) cell lineages are thought to emerge from alternative cell fate decisions. However, recent studies indicated that differentiated Th cells can adopt mixed phenotypes during secondary immunological challenges.
Michael Peine +9 more
doaj +1 more source
An in silico approach for modelling T-helper polarizing iNKT cell agonists [PDF]
, 2014 Many analogues of the glycolipid alpha-galactosylceramide (α-GalCer) are known to activate iNKT cells through their interaction with CD1d-expressing antigen-presenting cells, inducing the release of Th1 and Th2 cytokines. Because of iNKT cell involvement
ASPESLAGH, SANDRINE +9 more
core +7 more sources
Interleukin-33 promoting Th1 lymphocyte differentiation dependents on IL-12 [PDF]
, 2016 No abstract available.The pro-Th2 cytokine IL-33 is now emerging as an important Th1 cytokine-IFN-γ inducer in murine CD4+ T cells that is essential for protective cell-mediated immunity against viral infection in mice. However, whether IL-33 can promote
Komai-Koma, Mousa +5 more
core +1 more source
Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]
, 2009 Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core +1 more source
Molecular characterization of human CD4+ IL-10-producing regulatory cells [PDF]
, 2014 Previous studies in the group led to the identification of CD4+FOXP3- cells with regulatory functions in human blood that coproduce IL-10 and IFN-gamma.
De Simone, Marco <1975>
core +1 more source
Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1 [PDF]
, 2014 During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression
Brüstle, Anne +12 more
core +1 more source
Autoimmunity, 2017 Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease.
Weshely Kujur +6 more
doaj +1 more source
Immunological Medicine, 2022 Th17 cells are implicated in the pathogenesis of several autoimmune diseases. During the inflammation, Th17 cells exposed to IL-12 can shift towards the Th1 phenotype. These shifted cells are defined as ‘non-classic Th1 cells’.
Bo-Young Shin +5 more
doaj +1 more source