Results 121 to 130 of about 10,822,632 (330)

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

Plasmodium infection induces phenotypic, clonal, and spatial diversity among differentiating CD4+ T cells

Cell Reports
Summary: Naive CD4+ T cells must differentiate in order to orchestrate immunity to Plasmodium, yet understanding of their emerging phenotypes, clonality, spatial distributions, and cellular interactions remains incomplete.
Cameron G. Williams, Marcela L. Moreira, Takahiro Asatsuma, Hyun Jae Lee, Shihan Li, Irving Barrera, Evan Murray, Megan S.F. Soon, Jessica A. Engel, David S. Khoury, Shirley Le, Brooke J. Wanrooy, Dominick Schienstock, Yannick O. Alexandre, Oliver P. Skinner, Rainon Joseph, Lynette Beattie, Scott N. Mueller, Fei Chen, Ashraful Haque   +19 more
doaj   +1 more source

Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major

Nature Medicine, 2007
P. Darrah, Dipti T. Patel, P. D. Luca, R. Lindsay, Dylan F. Davey, Barbara Flynn, S. Hoff, P. Andersen, S. Reed, S. Morris, M. Roederer, R. Seder   +11 more
semanticscholar   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

New Insights into HIV Life Cycle, Th1/Th2 Shift during HIV Infection and Preferential Virus Infection of Th2 Cells: Implications of Early HIV Treatment Initiation and Care

Life
The theory of immune regulation involves a homeostatic balance between T-helper 1 (Th1) and T-helper 2 (Th2) responses. The Th1 and Th2 theories were introduced in 1986 as a result of studies in mice, whereby T-helper cell subsets were found to direct ...
Joseph Hokello, Kratika Tyagi, Richard Oriko Owor, Adhikarimayum Lakhikumar Sharma, Alok Bhushan, Rene Daniel, Mudit Tyagi   +6 more
doaj   +1 more source

Th1 cells inducing IFNγ response improves immunotherapy efficacy in gastric cancer. [PDF]

Chin J Cancer Res, 2023
Cao Q, Xue R, Zhang N.
europepmc   +1 more source

IL-7 Receptor Expression Provides the Potential for Long-Term Survival of Both CD62Lhigh Central Memory T Cells and Th1 Effector Cells during Leishmania major Infection [PDF]

, 2009
Sara L. Colpitts, Nicole M. Dalton, Phillip Scott   +2 more
openalex   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Co-adjuvanting DDA/TDB liposomes with a TLR7 agonist allows for IgG2a/c class-switching in the absence of Th1 cells. [PDF]

NPJ Vaccines, 2023
Zimmermann J, van Haren SD, Diray-Arce J, Adriawan IR, Wørzner K, Krog RT, Guleed S, Hu T, Mortensen R, Dietrich J, Solbak SMØ, Levy O, Christensen D, Pedersen GK.   +13 more
europepmc   +1 more source

Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis [PDF]

, 2005
Loes Linsen, Mariëlle Thewissen, Kurt Baeten, Veerle Somers, Piet Geusens, J. Raus, Piet Stinissen   +6 more
openalex   +1 more source