Results 121 to 130 of about 10,689,174 (395)

CSF cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (GFAP) autoimmunity

Annals of Clinical and Translational Neurology, Volume 12, Issue 4, Page 855-860, April 2025.
Abstract Defining the CSF cytokine/chemokine and injury biomarker signature of glial fibrillary acidic protein (GFAP) autoimmunity can inform immunopathogenesis. CSF GFAP‐IgG‐positive samples (N = 98) were tested for 17 cytokines/chemokines, neurofilament light chain (NfL), and GFAP (ELLA, Bio‐Techne).
Yahel Segal, Georgios Mangioris, Vanda Lennon, Binxia Yang, Divyanshu Dubey, Eoin P. Flanagan, Andrew McKeon, John R. Mills, Michel Toledano, Ivana Vodopivec, Sean J. Pittock, Anastasia Zekeridou   +11 more
wiley   +1 more source

Reconstitution of CXCR3+ CCR6+ Th17.1‐Like T Cells in Response to Ofatumumab Therapy in Patients With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang, Tian‐Xiang Zhang, Jia Liu, Zhirui Liu, Lijie Zhu, Yan‐Yan Li, Bin Feng, Moli Fan, Fu‐Dong Shi, Chao Zhang   +9 more
wiley   +1 more source

Recent Developments in Immune Network Theory including a concept for an HIV Vaccine [PDF]

arXiv, 2008
The symmetrical network theory is a framework for understanding the immune system, that dates back to the mid 1970s. The symmetrical network theory is based on symmetrical stimulatory, inhibitory and killing interactions between clones that are specific for each other.
arxiv  

CD4+CD25−Foxp3− Th1 cells are the source of IL-10–mediated immune suppression in chronic cutaneous leishmaniasis

Journal of Experimental Medicine, 2007
Nonhealing forms of leishmaniasis in humans are commonly associated with elevated levels of the deactivating cytokine IL-10, and in the mouse, normally chronic infections can be cleared in the absence of IL-10.
Charles F. Anderson, M. Oukka, Vijay Kuchroo, D. Sacks   +3 more
semanticscholar   +1 more source

CSF Tau Is a Biomarker of Hippocampal Injury in Cryptogenic New‐Onset Refractory Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cryptogenic new‐onset refractory status epilepticus (cNORSE) is a devastating condition characterized by the de novo onset of status epilepticus with unclear etiology. The identification of relevant early biomarkers in cNORSE is important to elucidate pathophysiology, aid clinical decision‐making, and prognosticate outcomes in cNORSE.
Yihui Goh, Yoonhyuk Jang, Soo Jean Shin, Soo Hyun Ahn, Su Yee Mon, Yoon Hee Shin, Kon Chu, Sang Kun Lee, Soon‐Tae Lee   +8 more
wiley   +1 more source

Adenosine A2A receptor-mediated interactions between Th1+ T cells and the choroid plexus epithelium via IFN-γ signalling control T-Cell infiltration in experimental autoimmune encephalomyelitis

Cell Communication and Signaling
Background Adenosine A2A receptor (A2AR) antagonists have been consistently demonstrated to protect against multiple sclerosis (MS) pathology, but A2AR knockout (A2AR−/−) mice exhibit exacerbated immune injury, raising concerns regarding the use of A2AR ...
Chenxing Qi, Yuwen Yang, Ping Tang, Cheng Zheng, Xuhang Li, Nan Jiang, Jia Qu, Jiang-Fan Chen, Wu Zheng   +8 more
doaj   +1 more source

PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment

Frontiers in Immunology
BackgroundInduced regulatory T cells (iTregs) are a heterogeneous population of immunosuppressive T cells with therapeutic potential. Treg cells show a range of plasticity and can acquire T effector-like capacities, as is the case for T helper 1 (Th1 ...
Nidhi Jadon, Sudarvili Shanthalingam, Gregory N. Tew, Lisa M. Minter, Lisa M. Minter   +4 more
doaj   +1 more source

Room temperature Ferromagnetism in Th1-xFexO2-d (x = 0.0, 0.05, 0.10, 0.15, 0.20 and 0.25) nanoparticles [PDF]

arXiv, 2007
Nanocrystalline (Th1-xFex)O2-d particles with different Fe concentrations (x = 0.0, 0.05, 0.10, 0.15, 0.20 and 0.25) have been prepared by a gel combustion method. Rietveld refinement analyses of X-ray diffraction data revealed the formation of an impurity free cubic type Th1-xFexO2-d structure up to x = 0.20. This observation is further confirmed from
arxiv  

A PANoptosis‐Based Signature for Survival and Immune Predication in Glioblastoma Multiforme

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PANoptosis is a concept of total cell death characterized by pyroptosis, apoptosis, and necroptosis. We aimed to explore the clinical significance of PANoptosis‐related genes (PARGs) in glioblastoma multiforme (GBM). Methods Expression profiles of GBM were downloaded from the XENA database as a training dataset to construct a ...
Jun Yang, Da Lin, Dongyuan Liu, Dongxu Zhang, Hao Wang   +4 more
wiley   +1 more source

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. [PDF]

, 1996
We previously demonstrated that a spontaneous Th1 response against glutamate decarboxylase (GAD65) arises in NOD mice at four weeks in age and subsequently T cell autoimmunity spreads both intramolecularly and intermolecularly.
Atkinson, MA, Clare-Salzler, M, Forsthuber, T, Herschenfeld, A, Kaufman, DL, Lehmann, PV, Tian, J   +6 more
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