Results 121 to 130 of about 189,103 (261)

gnSPADE: Incorporating Gene Network Structures Enhances Reference‐Free Deconvolution in Spatial Transcriptomics

Advanced Intelligent Systems, EarlyView.
gnSPADE integrates gene‐network structures into a probabilistic topic modeling framework to achieve reference‐free cell‐type deconvolution in spatial transcriptomics. By embedding gene connectivity within the generative process, gnSPADE enhances biological interpretability and accuracy across simulated and real datasets, revealing spatial organization ...
Aoqi Xie, Yuehua Cui
wiley   +1 more source

Comparative Analysis of Apigenin-3 Acetate versus Apigenin and Methyl-Prednisolone in Inhibiting Proliferation and Gene Expression of Th1 Cells in Multiple Sclerosis. [PDF]

Cell J, 2023
Kasiri N, Ghannadian SM, Hosseini R, Ahmadi L, Rahmati M, Ashtari F, Pourazar A, Eskandari N.   +7 more
europepmc   +1 more source

Comparative virology and pathology of Monkeypox virus in Syrian hamsters, C57BL/6, and BALB/c mice: A framework for preclinical model selection

Animal Models and Experimental Medicine, EarlyView.
This study compared monkeypox virus (MPXV) infection in three small animal models: Syrian hamsters, C57BL/6 mice, and BALB/c mice. Following intraperitoneal inoculation, Syrian hamsters exhibited the highest susceptibility, with rapid systemic viral dissemination, elevated splenic and renal viral burdens, and severe histopathological damage, followed ...
Xiaohui Wei, Jing Wu, Hekai Yang, Na Li, Binbin Zhao, Wanjun Peng, Na Rong, Wei Zhang, Jing Xue, Jiangning Liu   +9 more
wiley   +1 more source

The FoxO4/DKK3 axis represses IFN-γ expression by Th1 cells and limits antimicrobial immunity. [PDF]

J Clin Invest, 2022
Chen X, Hu J, Wang Y, Lee Y, Zhao X, Lu H, Zhu G, Wang H, Jiang Y, Liu F, Chen Y, Kim BS, Zhou Q, Liu X, Wang X, Chang SH, Dong C.   +16 more
europepmc   +1 more source

Confined B‐Cell Reconstruction and High T‐Cell Clonality Define Clinical Response to Cladribine Treatment

Annals of Neurology, EarlyView.
Cladribine tablets are approved for relapsing multiple sclerosis, mediating their clinical effect by moderately depleting lymphocytes. In a prospective, monocentric study including 22 patients completing 2 annual cycles of cladribine, B‐ and T‐cell receptor repertoires and relapse activity were assessed at baseline and after 24 months. T‐cell clonality
Tilman Schneider‐Hohendorf, Maria Eveslage, Timo Wirth, Christian Wünsch, Eva M. Schumann, Jan D. Lünemann, Heinz Wiendl, Luisa Klotz, Nicholas Schwab   +8 more
wiley   +1 more source

Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection. [PDF]

Front Immunol
Plajer V, Madrigal-Avilés A, Dzamukova M, Durán-Hernández N, Saikali P, Holecska V, Panse I, Lehmann K, Zhu J, Mashreghi MF, Hegazy AN, Peine C, Löhning M.   +12 more
europepmc   +1 more source

Evolutionarily conserved IL-27β enhances Th1 cells potential by triggering the JAK1/STAT1/T-bet axis in Nile tilapia. [PDF]

Fish Shellfish Immunol Rep, 2023
Geng M, Li K, Ai K, Liang W, Yang J, Wei X.   +5 more
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition. [PDF]

BMC Biol
Koch J, Ruggia A, Beha C, Wipf I, Zhakparov D, Westermann P, Schmelzer S, Heider A, Fröhlich K, Baerenfaller K.   +9 more
europepmc   +1 more source

LncRNA RUNX1-IT1 affects the differentiation of Th1 cells by regulating NrCAM transcription in Graves' disease. [PDF]

Cell Cycle, 2022
Huang FJ, Liu YL, Wang J, Zhou YY, Zhao SY, Qin GJ.   +5 more
europepmc   +1 more source