Results 11 to 20 of about 10,689,174 (395)

Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells [PDF]

The Journal of Immunology, 2017
Abstract Th17 cells are an important therapeutic target in autoimmunity. However, it is known that Th17 cells exhibit considerable plasticity, particularly at sites of autoimmune inflammation. Th17 cells can switch to become ex-Th17 cells that no longer produce IL-17 but produce IFN-γ. These ex-Th17 cells are also called nonclassical Th1
S. Basdeo, D. Cluxton, J. Sulaimani, B. Moran, M. Canavan, C. Orr, D. Veale, U. Fearon, J. Fletcher   +8 more
semanticscholar   +4 more sources

Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection [PDF]

PLoS Pathogens, 2015
Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain elusive. While the importance of cellular immunity has been shown in mice, T cell responses in humans have not been characterised.
Brown, A.F. (Aisling), Fennell, J.P. (Jérôme), Fitzgerald-Hughes, D. (Deirdre), Foster, T.J. (Timothy), Geoghegan, J.A. (Joan), Hearnden, C.H. (Claire), Humphreys, H. (Hilary), Lacey, K.A. (Keenan), Lalor, S.J. (Stephen), Lavelle, E.C. (Ed), Leech, J.M. (John), Mac Aogáin, M. (Micheál), McLoughlin, R.M. (Rachel), Murphy, A.G. (Alison), O’Halloran, D.P. (Dara), O’Keeffe, K.M. (Kate), Rogers, T.R. (Thomas), Tavakol, M. (Mehri), Wamel, W.J.B. (Willem) van   +18 more
core   +3 more sources

Astrocytes Modulate the Polarization of CD4+ T Cells to Th1 Cells

PLoS ONE, 2014
T-cell characteristics are dynamic and influenced by multiple factors. To test whether cells and the environment in the central nervous system (CNS) can influence T-cells, we tested if culturing mouse CD4+ T-cells on mouse primary astrocytes, compared ...
E. Beurel, L. Harrington, W. Buchser, V. Lemmon, R. Jope   +4 more
semanticscholar   +7 more sources

Delayed Activation Kinetics of Th2- and Th17 Cells Compared to Th1 Cells

Cells, 2017
During immune responses, different classes of T cells arise: Th1, Th2, and Th17. Mobilizing the right class plays a critical role in successful host defense and therefore defining the ratios of Th1/Th2/Th17 cells within the antigen-specific T cell ...
Andrea Duechting, Anna Przybyla, Stefanie Kuerten, Paul V. Lehmann   +3 more
doaj   +2 more sources

Th1 cells in cancer-associated inflammation

TURKISH JOURNAL OF BIOLOGY, 2017
* Correspondence: gunes.esendagli@lycos ...
Güneş Dinç Akbulut, D. Özkazanç, G. Esendagli   +2 more
semanticscholar   +4 more sources

Dissecting the dynamic transcriptional landscape of early T helper cell differentiation into Th1, Th2, and Th1/2 hybrid cells

Frontiers in Immunology, 2022
Selective differentiation of CD4+ T helper (Th) cells into specialized subsets such as Th1 and Th2 cells is a key element of the adaptive immune system driving appropriate immune responses. Besides those canonical Th-cell lineages, hybrid phenotypes such
Philipp Burt, Philipp Burt, Michael Peine, Michael Peine, Caroline Peine, Caroline Peine, Zuzanna Borek, Zuzanna Borek, Zuzanna Borek, Sebastian Serve, Sebastian Serve, Sebastian Serve, Michael Floßdorf, Ahmed N. Hegazy, Ahmed N. Hegazy, Ahmed N. Hegazy, Thomas Höfer, Max Löhning, Max Löhning, Kevin Thurley, Kevin Thurley, Kevin Thurley   +21 more
doaj   +3 more sources

Th1 and Th2 cells in autoimmunity [PDF]

Clinical and Experimental Immunology, 1995
P Druet, Sheela Ramanathan, Lucette Pelletier   +2 more
openalex   +5 more sources

Natural Th1 cells: escape from neglect

Oncotarget, 2015
A novel idea that there is an alternative pathway for intrathymic generation of mature CD4+ T cells came from the observation that immature thymocytes were also able to express MHC class II on their cell surfaces during fetal thymic development [1]. This
S. Park
semanticscholar   +4 more sources

The emerging role of Th1 cells in atherosclerosis and its implications for therapy. [PDF]

Front Immunol, 2022
Atherosclerosis is a chronic progressive inflammatory disease of the large and medium-sized artery walls. The molecular mechanisms regulating the onset and progression of atherosclerosis remain unclear.
Chen J, Xiang X, Nie L, Guo X, Zhang F, Wen C, Xia Y, Mao L.   +7 more
europepmc   +2 more sources

Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis [PDF]

Journal of Investigative Dermatology, 2010
Th17, Th22, and Th1 cells are detected in psoriatic skin lesions and implicated in psoriasis pathogenesis, but inflammatory T cell numbers in blood, as well as the relative importance of each cell type, is unclear.
Blauvelt, Andrew, Kagami, Shinji, Koguchi, Yoshinobu, Lee, Jennifer J., Rizzo, Heather L.   +4 more
core   +2 more sources