Results 221 to 230 of about 165,252 (249)
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TH1-TH2: a Procrustean paradigm
Nature Immunology, 2003Although immunologists have found the dichotomous helper T cell subset model a useful construct, it is beginning to show its age. Some suggest that proponents of the TH1-TH2 dichotomy are overzealous in making the data conform to the scheme, like Procrustes who stretched or truncated his guests so that they would fit his guest bed.
Dennis O, Gor +2 more
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NLRP3 moonlights in TH2 polarization
Nature Immunology, 2015As the cytosolic guardian for many microbial and sterile inflammatory insults, NLRP3 is best appreciated for its innate immunological role mediating inflammasome activation. Now NLRP3 debuts as a transcription factor key for TH2 polarization.
Jenny P Y Ting, Jonathan A Harton
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Th2 Cells: Orchestrating Barrier Immunity
2004Publisher Summary This chapter summarizes recent insights regarding the generation of T helper (Th) 2 cells and factors regulating expression of IL-4—the canonical cytokine secreted by these cells. Th2 cells orchestrate a stereotyped cell response characterized by eosinophil and basophil infiltration, mast cell hyperplasia, and changes in epithelial ...
Daniel B, Stetson +7 more
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Annals of the New York Academy of Sciences, 1996
TH2-type cytokines, particularly interleukin-5, together with granulocyte-macrophage colony-stimulating factor and interleukin-3, orchestrate the eosinophil response in asthma. Eosinophils are believed to be prime proinflammatory effector cells causing bronchial damage, which in turn, leads to chronic asthma symptoms.
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TH2-type cytokines, particularly interleukin-5, together with granulocyte-macrophage colony-stimulating factor and interleukin-3, orchestrate the eosinophil response in asthma. Eosinophils are believed to be prime proinflammatory effector cells causing bronchial damage, which in turn, leads to chronic asthma symptoms.
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Asthma phenotyping: TH2-high, TH2-low, and beyond
Journal of Allergy and Clinical Immunology, 2014Sterk, Peter J., Lutter, René
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