Results 31 to 40 of about 5,234,585 (193)

Caecum OX40+CD4 T-cell subset associates with mucosal damage and key markers of disease in treated HIV-infection

Journal of Microbiology, Immunology and Infection, 2023
Background: Blood OX40-expressing CD4 T-cells from antiretroviral (ART)-treated people living with HIV (PWH) were found to be enriched for clonally-expanded HIV sequences, hence contributing to the HIV reservoir. OX40-OX40L is also a checkpoint regulator
Isaac Rosado-Sánchez, Inés Herrero-Fernández, Salvador Sobrino, Ana E. Carvajal, Miguel Genebat, Laura Tarancón-Díez, María Carmen Garcia-Guerrero, María Carmen Puertas, Rocío M. de Pablos, Rocío Ruiz, Javier Martinez-Picado, Manuel Leal, Yolanda M. Pacheco   +12 more
doaj   +1 more source

B cells control lupus autoimmunity by inhibiting Th17 and promoting Th22 cells [PDF]

Cell Death & Disease, 2020
AbstractB cells exert immunosuppressive effects and offer therapeutic potential for systemic lupus erythematosus (SLE), but the mechanism remains unclear. Here we analyzed the B cell regulation of Th17/Th22 cell differentiation in lupus and found that α-IgM- and α-CD40-activated B cells could inhibit Th17 and promote Th22 cell differentiation from ...
Yang, Ji, Yang, Xue, Wang, Luman, Li, Ming   +3 more
openaire   +2 more sources

Decreased frequency of Th22 cells and IL-22 cytokine in kidney transplant patients with active cytomegalovirus infection

BMC Immunology, 2023
Background The immunity of CD4+ T cell subsets against human cytomegalovirus (HCMV) is considerable due to their essential role in controlling the infection in transplant individuals.
Yashgin Hassanzadeh, Ramin Yaghobi, Parviz Pakzad, Bita Geramizadeh   +3 more
doaj   +1 more source

Th22 cells are expanded in multiple sclerosis and are resistant to IFN-β [PDF]

Journal of Leukocyte Biology, 2014
AbstractTh1 and Th17 cells have been considered as effectors in mouse EAE and in the human counterpart, MS. Recently, IL-22, a Th17-related, proinflammatory cytokine, has been associated with a new Th cell subset, defined as Th22, involved in chronic inflammatory conditions, such as psoriasis; the role of IL-22 in MS has not yet been elucidated.
ROLLA, SIMONA, BARDINA, VALENTINA, DE MERCANTI, STEFANIA FEDERICA, QUAGLINO, Pietro, R. De Palma, D. Gned, D. Brusa, DURELLI, Luca, NOVELLI, Francesco, CLERICO, Marinella   +9 more
openaire   +4 more sources

Th17 and Th22 in skin allergy.

, 2012
Development of eczematous skin reactions depends on disease-specific and time-dependent recruitment of a variety of leukocytes affecting resident skin cells through cytotoxic mechanisms and release of cytokines.
Cavani, A;Pennino, D;Eyerich, K
core   +2 more sources

Helper T cell bias following tuberculosis chemotherapy identifies opportunities for therapeutic vaccination to prevent relapse

npj Vaccines, 2023
Therapeutic vaccines have promise as adjunctive treatment for tuberculosis (TB) or as preventives against TB relapse. An important development challenge is the limited understanding of T helper (Th) cell roles during these stages of disease.
Yazmin B. Martinez-Martinez, Matthew B. Huante, Sadhana Chauhan, Kubra F. Naqvi, Preeti Bharaj, Janice J. Endsley   +5 more
doaj   +1 more source

AhR Ligands Modulate the Differentiation of Innate Lymphoid Cells and T Helper Cell Subsets That Control the Severity of a Pulmonary Fungal Infection

Frontiers in Immunology, 2021
In agreement with other fungal infections, immunoprotection in pulmonary paracoccidioidomycosis (PCM) is mediated by Th1/Th17 cells whereas disease progression by prevalent Th2/Th9 immunity.
Eliseu F. de Araújo, Flávio V. Loures, Nycolas W. Preite, Cláudia Feriotti, Nayane AL Galdino, Tânia A. Costa, Vera L. G. Calich   +6 more
doaj   +1 more source

CD4+ cells in autoimmune thyroid disease

Endokrynologia Polska, 2021
The phenomenon of autoimmunity develops as a result of the triggering factor released by damaged cells. This leads to an infiltration of CD4+ cells involved in stimulating the effector cells cytotoxicity and stimulating the humoral response.
Szymon Janyga, Bogdan Marek, Dariusz Kajdaniuk, Monika Ogrodowczyk-Bobik, Agata Urbanek, Łukasz Bułdak   +5 more
doaj   +1 more source

Recruitment and significance of Th22 cells and Th17 cells in malignant ascites

Oncology Letters, 2018
T helper (Th)22 and Th17 cells are implicated in the pathogenesis of a number of types of cancer. However, the function of Th22 and Th17 cells in malignant ascites (MA) remains unknown. The present study aimed at examining the distribution, phenotypes, recruitment, and prognostic value of Th22 and Th17 cells in MA from patients with hepatocellular ...
Xian-Wen, Yang, Hai-Xing, Jiang, Ronge, Lei, Wei-Shun, Lu, Shi-Hui, Tan, Shan-Yu, Qin   +5 more
openaire   +3 more sources

Increased differentiation of Th22 cells in Hashimoto^|^rsquo;s thyroiditis

Endocrine Journal, 2014
As Th22 subsets are identified, their involvement in the pathogenesis of numerous autoimmune diseases has become apparent. In this study, we investigated differentiation of Th22 cells in the autoimmune thyroid diseases including Hashimoto's thyroiditis (HT) and Graves' disease (GD).
Bai, Xue, Sun, Jie, Wang, Weiwei, Shan, Zhongyan, Zheng, Hongzhi, Li, Yushu, Zhao, Yuhang, Gong, Ming, Teng, Weiping   +8 more
openaire   +3 more sources