Results 71 to 80 of about 12,071,270 (180)

Th22 cells increase in poor prognosis multiple myeloma and promote tumor cell growth and survival. [PDF]

Oncoimmunology, 2015
There is increased production of plasmacytoid dendritic cells (pDCs) in the bone marrow (BM) of multiple myeloma (MM) patients and these favor Th22 cell differentiation.
Di Lullo G, Marcatti M, Heltai S, Brunetto E, Tresoldi C, Bondanza A, Bonini C, Ponzoni M, Tonon G, Ciceri F, Bordignon C, Protti MP.   +11 more
europepmc   +2 more sources

Th22 cells are a major contributor to the mycobacterial CD4+ T cell response and are depleted during HIV infection

Journal of Immunology, 2019
Key Points IL-22 responses to mycobacterial Ags contributed ∼50% of the total response. Mycobacterial Th22 responses were significantly lower in HIV-infected individuals.
Rubina Bunjun, F. M. A. Omondi, Mohau S. Makatsa, Roanne S Keeton, Jerome M. Wendoh, Tracey L. Müller, C. S. Prentice, R. Wilkinson, C. Riou, W. Burgers   +9 more
semanticscholar   +1 more source

Increased Numbers of Circulating Th22 and Th17 Cells in Children With Kawasaki Disease [PDF]

, 2021
Abstract T-helper (Th) 17 and Th22 cells are critical for the pathogenic process of Kawasaki Disease (KD). A total of 43 children with freshly diagnosed KD and 20 healthy controls (HC) were quantified for the numbers of Th17, Th22 and Th1 cells by flow cytometry.
Zhang Liwen, Huang Zhiying, Xue Mei, Zhang Xiaoyu, Wang Fei, Zhao Xuan, Wan Yu, Ma Liang   +7 more
openaire   +1 more source

Helper T cell bias following tuberculosis chemotherapy identifies opportunities for therapeutic vaccination to prevent relapse

npj Vaccines, 2023
Therapeutic vaccines have promise as adjunctive treatment for tuberculosis (TB) or as preventives against TB relapse. An important development challenge is the limited understanding of T helper (Th) cell roles during these stages of disease.
Yazmin B. Martinez-Martinez, Matthew B. Huante, Sadhana Chauhan, Kubra F. Naqvi, Preeti Bharaj, Janice J. Endsley   +5 more
doaj   +1 more source

JAK Inhibitors in Psoriatic–Atopic Dermatitis Overlap: A Four‑Case Series

JEADV Clinical Practice, EarlyView.
ABSTRACT Overlap between psoriasis and atopic dermatitis (AD) poses diagnostic and therapeutic challenges; monoclonal antibodies targeting a single axis may improve one component while worsening the other [1]. Janus kinase (JAK) inhibitors act pleiotropically and may provide simultaneous control of psoriatic and eczematous inflammation [2].
Eleonora Bongiovanni, Francois Rosset, Isotta Giunipero di Corteranzo, Lorenzo Bellando, Rebecca Senetta, Simone Ribero, Pietro Quaglino   +6 more
wiley   +1 more source

Acteoside relieves mesangial cell injury by regulating Th22 cell chemotaxis and proliferation in IgA nephropathy

Renal Failure, 2018
The existing therapies of IgA nephropathy are unsatisfying. Acteoside, the main component of Rehmannia glutinosa with anti-inflammatory and anti-immune effects, can improve urinary protein excretion and immune disorder.
Lu Gan, Xiaozhao Li, Mengyuan Zhu, Chen Chen, Huimin Luo, Qiaoling Zhou   +5 more
doaj   +1 more source

T helper cell subsets specific for Pseudomonas aeruginosa in healthy individuals and patients with cystic fibrosis.

PLoS ONE, 2014
BackgroundWe set out to determine the magnitude of antigen-specific memory T helper cell responses to Pseudomonas aeruginosa in healthy humans and patients with cystic fibrosis.MethodsPeripheral blood human memory CD4(+) T cells were co-cultured with ...
Hannah K Bayes, Stephen Bicknell, Gordon MacGregor, Tom J Evans   +3 more
doaj   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Th17 but not Th22 cells display pathological behaviour in arthritis [PDF]

Annals of the Rheumatic Diseases, 2012
Background Th17 cells (IL-17+IL-22+) are critically involved in the induction and progression of arthritis. Recently, Th22 cells were discovered, which were characterised by IL-22 expression in the absence of IL-17. However, it remains unclear whether IL-22 and Th22 cells, directly contribute to synovial inflammation.
Jan Piet van Hamburg, Odilia B.J. Corneth, Sandra M.J. Paulissen, Nadine Davelaar, Patrick S. Asmawidjaja, Erik Lubberts   +5 more
openaire   +1 more source

Age‐related clinical heterogeneity and peripheral T cell profile alterations in primary Sjögren's disease: A retrospective study of 5778 patients

Rheumatology &Autoimmunity, EarlyView.
This large‐scale retrospective study of 5778 primary Sjögren's disease (SjD) patients, stratified by diagnostic age, defines a distinct clinical and immunological profile for early‐diagnosed (<45 years) disease. We identified early diagnosis as an independent risk factor for hypergammaglobulinemia and interstitial lung disease, underpinned by a ...
Yuan Ning, Ruiling Feng, Kai Zhang, Yipeng Han, Ruoyi Wang, Guangwen Li, Yuebo Jin, Jing He   +7 more
wiley   +1 more source